DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and SNAPC4

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001381130.1	Gene:	SNAPC4 / 6621	HGNCID:	11137	Length:	1469	Species:	Homo sapiens

Alignment Length:	697	Identity:	141/697 - (20%)
Similarity:	223/697 - (31%)	Gaps:	269/697 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEDEK 70
            :|.|.|...||..|..||.|||:..|.:|...:..:|..||:.|:...|..|:||..|:.:|:|:
Human   399 LKKGYWAPEEDAKLLQAVAKYGEQDWFKIREEVPGRSDAQCRDRYLRRLHFSLKKGRWNLKEEEQ 463

  Fly    71 LLHL-AKLMPTQWRTIA-PIIGRTAAQCLERYEYLLDQAQ----RKEDGEDTM------------ 117
            |:.| .|.....|..|| .:..|:.:|||.:::.::.:.|    |:.....::
Human   464 LIELIEKYGVGHWAKIASELPHRSGSQCLSKWKIMMGKKQGLRRRRRRARHSVRWSSTSSSGSSS 528

  Fly   118 ----------------DDPRKLKPGEID------------------------------------- 129
                            |:|.:.:.||.|
Human   529 GSSGGSSSSSSSSSEEDEPEQAQAGEGDRALLSPQYMVPDMDLWVPARQSTSQPWRGGAGAWLGG 593

  Fly   130 ---------------------------PNPETKPAR-------PDPKDMDEDELEMLSEARARLA 160
                                       |..||.|.:       |.|:          |...:..|
Human   594 PAASLSPPKGSSASQGGSKEASTTAAAPGEETSPVQVPARAHGPVPR----------SAQASHSA 648

  Fly   161 NTQGKKAKRKAREKQLEEARRLATL------------------QKRRELR-------AAGIGSGN 200
            :|:...|:::|    ||..|||.|:                  .::.:||       :.|:.||:
Human   649 DTRPAGAEKQA----LEGGRRLLTVPVETVLRVLRANTAARSCTQKEQLRQPPLPTSSPGVSSGD 709

  Fly   201 ---RKRIKGIDYNAEIPFEKRPAHGFY-------------------------------------D 225
               |..::.:.:.|....::|..|..:                                     |
Human   710 SVARSHVQWLRHRATQSGQRRWRHALHRRLLNRRLLLAVTPWVGDVVVPCTQASQRPAVVQTQAD 774

  Fly   226 TSEEHLQK----NEPDFNKMRQQ---DLDGELRSEKEERERKRDKQKLKQRKENEVPTAMLQNME 283
            ...|.||:    :.|.|....|.   |..|.|   :..||||....:|.|....:.|..:||...
Human   775 GLREQLQQARLASTPVFTLFTQLFHIDTAGCL---EVVRERKALPPRLPQAGARDPPVHLLQASS 836

  Fly   284 PERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITPQ---VAATP 345
            ..:.....:.|     ::..|:..|  .||.........|.:|.|         .||   :|:|.
Human   837 SAQSTPGHLFP-----NVPAQEASK--SASHKGSRRLASSRVERT---------LPQASLLASTG 885

  Fly   346 RTPAPYT------DRIMQEAQNMMA----------------------LTHTE--TPLKGG--LNT 378
            ..|.|.|      ::.:|||:...|                      |.||.  .|..|.  ||.
Human   886 PRPKPKTVSELLQEKRLQEARAREATRGPVVLPSQLLVSSSVILQPPLPHTPHGRPAPGPTVLNV 950

  Fly   379 PLHESDFSGVLPKAASIATPNTVIATPFRTQREGGAATPGGFQTPSSGALVPV--KGAGGATGVV 441
            ||     ||  |.|.:.|.|    .|....|..|.:|......|..:..|.||  :..|.|....
Human   951 PL-----SG--PGAPAAAKP----GTSGSWQEAGTSAKDKRLSTMQALPLAPVFSEAEGTAPAAS 1004

  Fly   442 NTPAYVRDKLSIN-PEESMGVTETPAHYKNYQKQLKSTLRDGLSTLP 487
            ..||....::|:: ||..:|.::.||          ::.:.||...|
Human  1005 QAPALGPGQISVSCPESGLGQSQAPA----------ASRKQGLPEAP 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	17/47 (36%)
		Myb_DNA-bind_6	11..71	CDD:290632	22/59 (37%)
		SANT_CDC5_II	56..108	CDD:212557	16/53 (30%)
		SANT	60..104	CDD:197842	14/45 (31%)
		Myb_Cef	397..648	CDD:288664	22/94 (23%)
SNAPC4	NP_001381130.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..82
		SNAPC5-binding. /evidence=ECO:0000269\|PubMed:11056176	84..133
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..558		7/56 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	577..661		11/97 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	685..710		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	834..894		15/75 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	932..981		19/59 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1001..1051		11/51 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1167
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1184..1266
		SNAPC2-binding. /evidence=ECO:0000269\|PubMed:11056176	1281..1393
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1430..1449
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810