DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc5 and mybl1

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_005162808.1	Gene:	mybl1 / 558540	ZFINID:	ZDB-GENE-041111-281	Length:	743	Species:	Danio rerio

Alignment Length:	778	Identity:	169/778 - (21%)
Similarity:	289/778 - (37%)	Gaps:	244/778 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEDEKLLHLA 75
            |...|||.||..|.:.|.:.|..||:....::..||:.||.:.|:|.:.|..|::|||::::.|.
Zfish    37 WSRDEDEKLKKLVEQQGTDNWKLIANYFPTRTDGQCQHRWQKVLNPELVKGPWTKEEDQRVIELV 101

  Fly    76 -KLMPTQWRTIAP-IIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDPNPETKPAR 138
             |..|.:|..||. :.||...||.||:...|                          |||.|.:
Zfish   102 HKYGPKRWSVIAKHLQGRIGKQCRERWHNHL--------------------------NPEVKKS- 139

  Fly   139 PDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQK------RRELRAAG-I 196
                ...::|..::.||..||.|       |.|...:|...|...:::.      ||::...| :
Zfish   140 ----SWTQEEDRIIYEAHKRLGN-------RWAEISKLLPGRTDNSIKNHWNSTMRRKVEHEGYL 193

  Fly   197 GSGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEP-----------DFNKMRQQDLDG-E 249
            ..||:      .||::...:|||...  .|.|....:|:|           .:.....|.|:. .
Zfish   194 QEGNK------SYNSDPGQKKRPKSS--PTVEYPHDQNQPILSGQSQPPRYPYRSQSAQCLENIN 250

  Fly   250 LRSEKEERERKRDKQKLKQRKENEVPTAMLQNMEPERKRS------------KLVLPTPQISDME 302
            :|..........|..|.|:.||.|:   :|.:.|.|.:|.            ...||...:..:|
Zfish   251 VRISSFVSPFHDDPDKEKRIKELEL---LLMSAESEVRRQSGPRNPESYSSWSDSLPDDSVESVE 312

  Fly   303 LQQVVKLGRASEM------AKEIAGESGIETTDALLADYSITPQVAAT-------PRTPAPYTDR 354
             .:.|:.||:..:      :|.:|.|:     .|:|:.....|:.|.|       .|.|..::|.
Zfish   313 -DRGVEDGRSVSIPLPVSPSKFLAAEA-----SAVLSTLETIPEFAETMELIDSVSRDPLAWSDV 371

  Fly   355 I---MQEAQNMMALTH-----TETPLKGGLNTPLHES----------DFSGVLPKAA--SIATPN 399
            .   :.|:......|:     ||| |...:|.|..::          ..||.||...  ..::|.
Zfish   372 TSFDLSESGPSPKPTNPADVCTET-LAFPINAPTVQTMTRPCAAVSQGKSGTLPNTCMNRFSSPP 435

  Fly   400 TVIATPFRTQREGGAATPGGFQTPS-------SGALVPVKG-----------AGG---------- 436
            |.|..  :.:||||..:|...::.|       |....||||           :||
Zfish   436 TSICR--KKRREGGDQSPAEERSCSYIDNSGNSPKHTPVKGLPFSPSQFFNVSGGEPLSLDNPAL 498

  Fly   437 -ATGV------VNTPAYVRDKLSINPEESMG-------------VTETPAHYKN---YQKQLKST 478
             :|.|      :||| :.::....:.:|:.|             ...||..:||   .|:::...
Zfish   499 TSTPVCGQKCLLNTP-HQKETTPKHQKENAGFRTPKLHKNIVVHTPRTPTPFKNALAAQEKMHGP 562

  Fly   479 LRDGLSTLPAPRNDYEIVVPEQEESERIETNSEPAVEDQADVDARLLAEQEARRKRELEKRSQVI 543
            ||    .:|.|     :.:.|::..|.::.      |..||:..::..:.:.|...::|..::.:
Zfish   563 LR----MVPQP-----LALLEEDIREVLKE------ETGADIFTQVQNQLQYRSYEQMEAPARKV 612

  Fly   544 QRSLPRPTE----VNTKILRPQSEKQNLTEQQQAEELIKHEMITMQLY---------DSVKD--- 592
            ::||...:.    :|.::. ||.:..|.....|::.|:...|:.|.|.         :|:||
Zfish   613 RKSLVLDSWEKDCLNVQLF-PQQQINNNGTTSQSDGLLTRSMLMMPLTEREENSCSPESLKDSLS 676

  Fly   593 -----------------------PVP----------GQSQHKL---EQLQSYFKANPYEDISQ 619
                                   |.|          |:::.:|   ||.:.|...||...||:
Zfish   677 VVCSVSPQGKRENMIQRSPLYQTPTPANNEWDAVVFGKTEDQLIMTEQARRYLNPNPTACISR 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	16/44 (36%)
		Myb_DNA-bind_6	11..71	CDD:290632	22/59 (37%)
		SANT_CDC5_II	56..108	CDD:212557	19/53 (36%)
		SANT	60..104	CDD:197842	17/45 (38%)
		Myb_Cef	397..648	CDD:288664	64/326 (20%)
mybl1	XP_005162808.1	SANT	36..82	CDD:197842	16/44 (36%)
		Myb_DNA-bind_6	37..97	CDD:290632	22/59 (37%)
		SANT	86..134	CDD:197842	18/73 (25%)
		Myb_DNA-binding	86..132	CDD:278669	17/45 (38%)
		SANT	138..185	CDD:197842	10/58 (17%)
		Myb_DNA-binding	138..183	CDD:278669	10/56 (18%)
		LMSTEN	245..287	CDD:285262	11/44 (25%)
		Cmyb_C	477..638	CDD:286408	30/177 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900