DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cdc5 and Ttf1

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_006233944.1	Gene:	Ttf1 / 499766	RGDID:	1565673	Length:	912	Species:	Rattus norvegicus

Alignment Length:	772	Identity:	147/772 - (19%)
Similarity:	260/772 - (33%)	Gaps:	244/772 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 ATLQKRRELRAAGIGSGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEPDFN--KMRQQD 245
            |||.|:::.     .|.:.||:           :|.|:        :||:..:|..:  |.|:::
  Rat    39 ATLHKKKKW-----SSVSEKRL-----------QKWPS--------QHLESEQPQVSVRKKRRRE 79

  Fly   246 LDGELRSEKEERERKRDKQKLKQRKENEVP-----------------------TAMLQNMEPE-- 285
            .....:...|..:..:.|:|.|:|:|::.|                       |...:|:|.|
  Rat    80 SQTPAQESLESEQPWKAKKKKKRRRESQTPAQESLESEQTPMSMLGKRRRESQTPAQENLESEQP 144

  Fly   286 ----RKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITPQVAATPR 346
                :|:.:....||....:|.:|..|..|..:..||     ..:.|.:||.:   :.......:
  Rat   145 WKAKKKKRRREYQTPAEESLESEQPWKAKRKKKKEKE-----SQQLTSSLLKN---SETFHKAKK 201

  Fly   347 TPAPY-------------TDRIMQEAQNMMALTHTETP---------LKGGLNTPLHESDFSGVL 389
            |.|.:             |..|:.:.:||..|..|...         .||..:..::|::   .|
  Rat   202 TTAAHKKKKNSVWEVDMETGIILVDKENMENLLETSRKDVDIVYVDMSKGQRSAKVNETE---EL 263

  Fly   390 PKAASIATPNTVIATPFRTQR--------------EGGAATPGGFQTPSSGALVPVKGAGGATGV 440
            |.|.:.......:.:..|:::              :|  ..|.....|.|.:|.||...|..|.:
  Rat   264 PMAETQKRDCRELHSDIRSKKNQKHPQKIAPQDAIQG--TQPERISLPQSESLSPVDLEGKNTKI 326

  Fly   441 -VNTPAYVRDKLSINPE-----ESMGVTET------PAHY--------------KNYQKQLKSTL 479
             |......:.|:..:.|     ||:..:||      .||:              ::::.:.||..
  Rat   327 AVFCKKKSKKKVFRSQELEAVSESLVSSETIPESLDSAHHGGEDETEEEGESIKESHRIRKKSKK 391

  Fly   480 RDGLSTLPAPRNDYEIVVPEQEESERIETNSEPAVEDQADVD-ARLLAEQEARRKRELEKRSQVI 543
            :...|...|...|...|:....||..:::........:.||| ....||.:|   |..||..:.|
  Rat   392 KKHKSVTLATSGDSVSVLDSTAESALVDSPEGSGTLREEDVDHGSTEAEAQA---RPTEKHRKEI 453

  Fly   544 QRSLPRPTEVNTKILRPQSEKQNLTEQQQAEELIKHEMITMQLYDSVKDPVPGQSQHKLEQLQSY 608
            ||            |.|..|:.||.....:        .|..:.:..:|
  Rat   454 QR------------LEPTHEESNLESASNS--------ATRCVSEDRRD---------------- 482

  Fly   609 FKANPYEDISQQELAKAKQMLTEEMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQHRYTRA 673
                  .|.|..:|..|.:.|.|.:..::||.|      ....:::::.||:.....:|....|.
  Rat   483 ------SDESDVDLGSAVRQLQEFIPDIQERAA------TTIRRMYRDDLGRFKEFKAQGVAIRF 535

  Fly   674 NLASKKDR---------------LESAEKRLETN------------------RRHMAKEAKRCGK 705
            ...|.|:.               :|||:|.|.|:                  |.|:.|...|..|
  Rat   536 GKFSVKENKQIEKNVQDFLSLTGIESADKLLYTDRYPEEKSLITNLKRKHAFRLHIGKGIARPWK 600

  Fly   706 I----EKKL---KILTGGYQARAQVLIKQLQDTYGQIEQN----------SVSLSTFRFLGEQE- 752
            :    .||:   ....|.|.......:|.....:|...:.          ||:|...:..|::.
  Rat   601 LVYYRAKKIFDVNNYKGRYNEEDTKKLKAYHSLHGNDWKKIGAMVARSSLSVALKFSQIDGDRNH 665

  Fly   753 ---AIAVPRRLESLQEDVRRQMDREKELQQKYASLVEE--------RDSLYSQIEHI 798
               :.|..:||....|||..:....:||::..:.|.|:        |:.||..|..:
  Rat   666 GTWSKAETQRLIKAVEDVILKKMSSQELRELDSRLQEDPEGRLSIVREKLYKGISWV 722

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842
		Myb_DNA-bind_6	11..71	CDD:290632
		SANT_CDC5_II	56..108	CDD:212557
		SANT	60..104	CDD:197842
		Myb_Cef	397..648	CDD:288664	55/291 (19%)
Ttf1	XP_006233944.1	Myb_DNA-bind_6	621..676	CDD:290632	7/54 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900