DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and MYB

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_001123645.1	Gene:	MYB / 4602	HGNCID:	7545	Length:	761	Species:	Homo sapiens

Alignment Length:	839	Identity:	170/839 - (20%)
Similarity:	285/839 - (33%)	Gaps:	256/839 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEDEKLLHLA 75
            |...|||.||..|.:.|.:.|..||:.|..::..||:.||.:.|:|.:.|..|::|||::::.|.
Human    43 WTREEDEKLKKLVEQNGTDDWKVIANYLPNRTDVQCQHRWQKVLNPELIKGPWTKEEDQRVIELV 107

  Fly    76 -KLMPTQWRTIAP-IIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDPNPETKPAR 138
             |..|.:|..||. :.||...||.||:...|                          |||.|..
Human   108 QKYGPKRWSVIAKHLKGRIGKQCRERWHNHL--------------------------NPEVKKT- 145

  Fly   139 PDPKDMDEDELEMLSEARARLANTQGKKAK--------------RKAREKQLEEARRLATLQKRR 189
                ...|:|..::.:|..||.|...:.||              .....:::|:.   ..||:..
Human   146 ----SWTEEEDRIIYQAHKRLGNRWAEIAKLLPGRTDNAIKNHWNSTMRRKVEQE---GYLQESS 203

  Fly   190 ELRAAGIGSGNRKRIKGIDYNAEIPFEKRPAHG---------FYDTSE-EHLQKNEP-------D 237
            :.....:.:..:|....:.:....|..:.||.|         :|..|| :::..:.|       :
Human   204 KASQPAVATSFQKNSHLMGFAQAPPTAQLPATGQPTVNNDYSYYHISEAQNVSSHVPYPVALHVN 268

  Fly   238 FNKMRQQDLDGELRSEKEERERKRDKQKLKQRKENEVPTAMLQNMEPERKRSKLVLPTPQ----- 297
            ...:.|.......|...:|     |.:|.|:.||.|:   :|.:.|.|.| .:.||||..
Human   269 IVNVPQPAAAAIQRHYNDE-----DPEKEKRIKELEL---LLMSTENELK-GQQVLPTQNHTCSY 324

  Fly   298 -------ISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITPQVAATP-RTPAPYTDR 354
                   |:|.....    |.::.::  ..||.  .:|.:|.||....|:.:|:| |....:...
Human   325 PGWHSTTIADHTRPH----GDSAPVS--CLGEH--HSTPSLPADPGSLPEESASPARCMIVHQGT 381

  Fly   355 IMQEAQNMMALTHTETPLKGGLNT--------PLHESDFSGVLP------KAASIATPNTVIATP 405
            |:...:|::....|...:....::        ...|:|||   |      ||..:
Human   382 ILDNVKNLLEFAETLQFIDSDSSSWCDLSSFEFFEEADFS---PSQHHTGKALQL---------- 433

  Fly   406 FRTQREGGAATPGGFQTP-------SSGALVPVK-------------------GAGG--ATGVVN 442
              .||||....|.|..:|       |..:|.|.|                   |...  |||..:
Human   434 --QQREGNGTKPAGEPSPRVNKRMLSESSLDPPKVLPPARHSTIPLVILRKKRGQASPLATGDCS 496

  Fly   443 TPAYVRDKLSINPEES--MGVTETPAHYKNYQKQLKSTLRDGLSTLPAPRNDYEIVVPEQEESER 505
            :..:. |..|..|:.|  ..:..:|:.:.|....                       .|..:.|.
Human   497 SFIFA-DVSSSTPKRSPVKSLPFSPSQFLNTSSN-----------------------HENSDLEM 537

  Fly   506 IETNSEPAVEDQADVDARLLAEQEARRKRELEKRSQVIQRSLPRPTEVNTKILRPQSEKQNLTEQ 570
            ....|.|.:..:..|......:|..:.::|                  ||....|..::..|...
Human   538 PSLTSTPLIGHKLTVTTPFHRDQTVKTQKE------------------NTVFRTPAIKRSILESS 584

  Fly   571 QQAEELIKHEMITMQL-YDSVKDPVPGQSQHKLEQLQSYFKANPYEDISQQELAKAKQMLTEEME 634
            .:.....||.:...:: |..:| .:|....|.:|.||         |:.:||        ::|..
Human   585 PRTPTPFKHALAAQEIKYGPLK-MLPQTPSHLVEDLQ---------DVIKQE--------SDESG 631

  Fly   635 VVKERMAHG-----------ELPLD-----VYAQVWQ-ECLGQVLYLPSQHRYTRANLASKKDRL 682
            :|.|...:|           |.|.|     ..:..|: :.|...|:..:.......|:.:....:
Human   632 IVAEFQENGPPLLKKIKQEVESPTDKSGNFFCSHHWEGDSLNTQLFTQTSPVADAPNILTSSVLM 696

  Fly   683 ESAEKRLETN---------RRHMAK---------EAKRCGKIEKKLKILTGGYQARAQV 723
            ..|.:. |.|         .|.:|.         |...|||:|::   :|...|||..|
Human   697 APASED-EDNVLKAFTVPKNRSLASPLQPCSSTWEPASCGKMEEQ---MTSSSQARKYV 751

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	17/44 (39%)
		Myb_DNA-bind_6	11..71	CDD:290632	23/59 (39%)
		SANT_CDC5_II	56..108	CDD:212557	19/53 (36%)
		SANT	60..104	CDD:197842	17/45 (38%)
		Myb_Cef	397..648	CDD:288664	50/292 (17%)
MYB	NP_001123645.1	SANT	40..88	CDD:197842	17/44 (39%)
		Myb_DNA-binding	40..86	CDD:278669	16/42 (38%)
		SANT	92..140	CDD:197842	18/73 (25%)
		Myb_DNA-binding	92..138	CDD:278669	17/45 (38%)
		SANT	144..191	CDD:197842	8/51 (16%)
		Myb_DNA-binding	144..189	CDD:278669	8/49 (16%)
		LMSTEN	269..313	CDD:285262	13/52 (25%)
		Cmyb_C	518..683	CDD:286408	35/223 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810