DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and Mybl1

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	XP_038965321.1	Gene:	Mybl1 / 297783	RGDID:	1306940	Length:	774	Species:	Rattus norvegicus

Alignment Length:	856	Identity:	175/856 - (20%)
Similarity:	297/856 - (34%)	Gaps:	275/856 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEDEKLLHLA 75
            |...||:.||..|.::|.:.|:.|||.|..:|..||:.||.:.|:|.:.|..|::|||::::.|.
  Rat    61 WTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELV 125

  Fly    76 -KLMPTQWRTIAP-IIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDPNPETKPAR 138
             |..|.:|..||. :.||...||.||:...|                          |||.|.:
  Rat   126 QKYGPKRWSLIAKHLKGRIGKQCRERWHNHL--------------------------NPEVKKS- 163

  Fly   139 PDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQK------RRELRAAG-I 196
                ...|:|..::.||..||.|...:.||       |...|...:::.      ||::...| :
  Rat   164 ----SWTEEEDRIIYEAHKRLGNRWAEIAK-------LLPGRTDNSIKNHWNSTMRRKVEQEGYL 217

  Fly   197 GSGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQ-KNE--------------PDFNKMRQQDL 246
            ..|    ||....::::  :.:|.     .:.:||| :|:              ||.|.:.....
  Rat   218 QDG----IKSERSSSKL--QHKPC-----ATMDHLQTQNQFYIPVQIPGYQYVSPDGNCVEHVQT 271

  Fly   247 DGELR----SEKEERERK-RDKQKLKQRKENEV--------PTAM----------------LQNM 282
            ...::    .|..::|:| ::.:.|....||||        |.:.                |.|:
  Rat   272 SAFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNL 336

  Fly   283 EPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITPQVAAT--- 344
            |..         |.:...|:..|.|. .:.:...|.:|.|:     :|:|:.....|:.|.|
  Rat   337 EEH---------TTEFYSMDENQTVS-AQQNSPTKFLAVEA-----NAVLSSLQTIPEFAETLEL 386

  Fly   345 -PRTPAPYTD------------RIMQEAQNMMALTHTETPLKGGLNTPL----HESDFSGVLPKA 392
             ...|..::|            .:......:|.:.|.|..::...|..|    .::..:|...:|
  Rat   387 IESDPVAWSDVTSFDLSDAAASPVKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNSCNGGDSEA 451

  Fly   393 ASIATPNTVIATPFRTQREGGAATPGGFQTPSSGALVPVKGAGGATGVVNTPAYVRDKLSINPEE 457
            ..:|:||.|                 .|.||                    |..:|.|..:...:
  Rat   452 IPLASPNVV-----------------KFSTP--------------------PTILRKKKRLRVGQ 479

  Fly   458 SMGVTETPAHYKNYQKQL-KSTLRDG---------LSTLPAPRNDYEIVVP--EQEESERIETNS 510
            |.|            .:| :.:|.:|         :.|||...:.:....|  ||...|.....|
  Rat   480 SAG------------SELGEGSLSEGNNAALKHTPVKTLPFSPSQFFNTCPGSEQLNIENPSFTS 532

  Fly   511 EPAVEDQADVDARLLAEQEARRKRELEK---RSQVIQRSL----PRPTEVNTKILRPQSEKQNLT 568
            .|....:..:...|  ::||..|.:.|.   |:..|:||:    ||........|..|.:|....
  Rat   533 TPICGQKVLITTPL--QKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKKYGPL 595

  Fly   569 E---------QQQAEELIKHEMITMQLYDSVKDPVPGQSQHKLEQ------------LQSYFKAN 612
            :         ::...|::|.|..| .::...:|. |.....|.|.            |:|:.|..
  Rat   596 KIVSQPLAFLEEDIREVLKEETGT-DIFLKEEDE-PAYKSCKQEHSASVKKVRKSLALESWDKEE 658

  Fly   613 P-----YEDISQQELAKAKQMLTEEMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQHRYTR 672
            |     .||||..:   ::.:||..:.::.....|.                           .|
  Rat   659 PGTQLLTEDISDMQ---SENILTTSLLMIPLLEIHD---------------------------NR 693

  Fly   673 ANLASKKDRLESAEKRLETNRRHMAKEAKRCGKIEKKLKILTGGYQARAQ---VLIKQLQDTYGQ 734
            .||..:|..:.||.|.....::.......:..|:||.|       |:..:   |:..:.:|....
  Rat   694 CNLTPEKQDINSANKTYTLTKKRPNPNTCKAVKLEKSL-------QSNCEWETVVYGKTEDQLIM 751

  Fly   735 IEQNSVSLSTF 745
            .||....|||:
  Rat   752 TEQARRYLSTY 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	18/44 (41%)
		Myb_DNA-bind_6	11..71	CDD:290632	24/59 (41%)
		SANT_CDC5_II	56..108	CDD:212557	19/53 (36%)
		SANT	60..104	CDD:197842	17/45 (38%)
		Myb_Cef	397..648	CDD:288664	56/295 (19%)
Mybl1	XP_038965321.1	Myb_DNA-bind_6	61..121	CDD:372817	24/59 (41%)
		PLN03091	107..>215	CDD:215570	35/145 (24%)
		LMSTEN	265..308	CDD:400376	8/42 (19%)
		Cmyb_C	508..667	CDD:401307	32/162 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810