DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and Dmtf1

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_035936.3	Gene:	Dmtf1 / 23857	MGIID:	1344415	Length:	761	Species:	Mus musculus

Alignment Length:	720	Identity:	124/720 - (17%)
Similarity:	245/720 - (34%)	Gaps:	213/720 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKT---------- 61
            |.|:|...|.:||...:.:|.|.:..:.|:.:..:.:|..:..:|..:...:.:.
Mouse   152 KQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLR 216

  Fly    62 ---------EWSREEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKEDGEDTM 117
                     :::.||.|||..|.......|.||...:||:|:...:|...:.|..   ..|:.|.
Mouse   217 MYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTC---NTGKWTE 278

  Fly   118 DDPRKL----------KPGEIDPNPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAR 172
            ::.::|          :||:|...                     ..:.|.:|...|.:::::.|
Mouse   279 EEEKRLAEVVHELTSTEPGDIVTQ---------------------GVSWAAVAERVGTRSEKQCR 322

  Fly   173 EKQLEEARRLATLQKRRELRAAGIGSGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQKNEPD 237
            .|.|...                    |.|:..|.::..|              .|.:|.....:
Mouse   323 SKWLNYL--------------------NWKQSGGTEWTKE--------------DEINLILRIAE 353

  Fly   238 FNKMRQQDLDGELRSEKEERERKRD---------KQKLKQRKENEVPTAM--LQNMEPERKRSKL 291
            .:...:.|::.:|.:|.....|...         |:::...|:...|..:  |:.:...:|.:.:
Mouse   354 LDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPV 418

  Fly   292 VLPTPQISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITPQVAA----TPRTPAPYT 352
            :|                        |....||:..::...:...:..:||.    |..:|:|
Mouse   419 LL------------------------ENKSGSGVPNSNCNSSVQHVQIRVARLEDNTAISPSP-- 457

  Fly   353 DRIMQEAQNMMALTHTETPLKGGLNTPLHESDFSGVLPKAASIATPNTVIATPFRTQREGGAATP 417
               |...|..:.:||..:     .::|....|...:...:.::.|  ..|...|..|..|   ||
Mouse   458 ---MAALQIPVQITHVSS-----TDSPAASVDSETITLNSGTLQT--FEILPSFHLQPTG---TP 509

  Fly   418 GGF--QTPSSGALVPVKGAGGATGVVNTPAYVRDKLSINPEESMGVTETPAHYKNYQKQLKSTLR 480
            |.:  ||.||..| |:      |...|....:......:||:.:....:|.|..|....:.....
Mouse   510 GTYLLQTSSSQGL-PL------TLTTNPTVTLAAAAPASPEQIIVHALSPEHLLNTSDNVTVQCH 567

  Fly   481 DGLSTLPAPRNDYEIVVPEQEESERIETNSEPAVEDQADVDARLLAEQEARRKRELEKRSQVIQR 545
                   .||     |:.:...:|.|.::..   :::..||:.|.:.........||  :.....
Mouse   568 -------TPR-----VIIQTVATEDITSSLS---QEELTVDSDLHSSDFPEPPDALE--ADTFPD 615

  Fly   546 SLPRPTEVNTKILRPQSEKQNLTE--QQQAEELIKHEMITMQLYDSVKDPVPGQSQHKLEQLQSY 608
            .:|||    ...::|.....::::  .|.:.||:...|:..:  :.:.|
Mouse   616 EIPRP----KMTIQPSFNNAHVSKFSDQNSTELMNSVMVRTE--EEIAD---------------- 658

  Fly   609 FKANPYEDISQQE----LAKAKQMLTEEMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQHR 669
                  .|:.|:|    ||.|  .:||::|  ...:.|     .|:..:..|   .:|.:||.|.
Mouse   659 ------TDLKQEEPPSDLASA--YVTEDLE--SPTIVH-----QVHQTIDDE---TILIVPSPHG 705

  Fly   670 YTRAN 674
            :.:|:
Mouse   706 FIQAS 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	10/47 (21%)
		Myb_DNA-bind_6	11..71	CDD:290632	12/78 (15%)
		SANT_CDC5_II	56..108	CDD:212557	14/70 (20%)
		SANT	60..104	CDD:197842	13/62 (21%)
		Myb_Cef	397..648	CDD:288664	50/258 (19%)
Dmtf1	NP_035936.3	Interaction with CCND2	1..237		16/84 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..51
		Required for DNA-binding	87..458		61/392 (16%)
		Required for transcriptional activation	87..170		6/17 (35%)
		REB1	<122..378	CDD:227476	47/283 (17%)
		Interaction with CCND1, CCND2 and CCND3. /evidence=ECO:0000269\|PubMed:8887674	176..761		116/696 (17%)
		Myb_DNA-bind_6	228..284	CDD:372817	16/58 (28%)
		Myb_DNA-binding	274..329	CDD:365977	12/75 (16%)
		Required for transcriptional activation	459..761		62/326 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..625		8/49 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	740..761
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900