DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and Mybl1

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_032677.2	Gene:	Mybl1 / 17864	MGIID:	99925	Length:	751	Species:	Mus musculus

Alignment Length:	860	Identity:	177/860 - (20%)
Similarity:	294/860 - (34%)	Gaps:	283/860 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 WRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSREEDEKLLHLA 75
            |...||:.||..|.::|.:.|:.|||.|..:|..||:.||.:.|:|.:.|..|::|||::::.|.
Mouse    38 WTRDEDDKLKKLVEQHGTDDWTLIASHLQNRSDFQCQHRWQKVLNPELIKGPWTKEEDQRVIELV 102

  Fly    76 -KLMPTQWRTIAP-IIGRTAAQCLERYEYLLDQAQRKEDGEDTMDDPRKLKPGEIDPNPETKPAR 138
             |..|.:|..||. :.||...||.||:...|                          |||.|.:
Mouse   103 QKYGPKRWSLIAKHLKGRIGKQCRERWHNHL--------------------------NPEVKKS- 140

  Fly   139 PDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQK------RRELRAAG-I 196
                ...|:|..::.||..||.|...:.||       |...|...:::.      ||::...| :
Mouse   141 ----SWTEEEDRIIYEAHKRLGNRWAEIAK-------LLPGRTDNSIKNHWNSTMRRKVEQEGYL 194

  Fly   197 GSGNRKRIKGIDYNAEIPFEKRPAHGFYDTSEEHLQ-KNE--------------PDFNKMRQQDL 246
            ..|    ||....::::  :.:|.     .:.:||| :|:              ||.|.:.....
Mouse   195 QDG----IKSERSSSKL--QHKPC-----ATMDHLQTQNQFYIPVQIPGYQYVSPDGNCVEHVQT 248

  Fly   247 DGELR----SEKEERERK-RDKQKLKQRKENEV--------PTAM----------------LQNM 282
            ...::    .|..::|:| ::.:.|....||||        |.:.                |.|:
Mouse   249 SAFIQQPFVDEDPDKEKKIKELELLLMSAENEVRRKRLPPQPGSFSSWSGSFLMDDSMSNTLNNL 313

  Fly   283 EPERKRSKLVLPTPQISDMELQQVVKLGRASEMAKEIAGESGIETTDALLADYSITPQVAAT--- 344
            |..         |.:...|:..|.|. .:.:...|.:|.|:     :|:|:.....|:.|.|
Mouse   314 EEH---------TTEFYSMDENQTVS-AQQNSPTKFLAVEA-----NAVLSSLQTIPEFAETLEL 363

  Fly   345 -PRTPAPYTD------------RIMQEAQNMMALTHTETPLKGGLNTPL----HESDFSGVLPKA 392
             ...|..::|            .:......:|.:.|.|..::...|..|    .::..:|...:|
Mouse   364 IESDPVAWSDVTSFDLSDAAASPVKSTPVKLMRIQHNEGAMECQFNVSLVLEGKKNSRNGGDSEA 428

  Fly   393 ASIATPNTVIATPFRTQREGGAATPGGFQTPSSGALVPVKGAGGATGVVNTPAYVRDKLSINPEE 457
            ..:.:||.|                 .|.||                    |..:|.|..|...:
Mouse   429 IPLTSPNVV-----------------KFSTP--------------------PTILRKKKRIRVGQ 456

  Fly   458 SMGVTETPAHYKNYQKQLKSTLRDG--------------LSTLPAPRNDYEIVVP--EQEESERI 506
            |.|                |.|.||              :.|||...:.:....|  ||...|..
Mouse   457 SAG----------------SELGDGSLSEVGNAALKHTPVKTLPFSPSQFFNTCPGNEQLNIENP 505

  Fly   507 ETNSEPAVEDQADVDARLLAEQEARRKRELEK---RSQVIQRSL----PRPTEVNTKILRPQSEK 564
            ...|.|....:..:...|  ::||..|.:.|.   |:..|:||:    ||........|..|.:|
Mouse   506 SFTSTPICGQKVLITTPL--QKEATPKDQKENVGFRTPTIRRSILGTTPRTPTPFKNALAAQEKK 568

  Fly   565 QNLTE---------QQQAEELIKHEMITMQLYDSVKDPVPGQSQHKLEQ------------LQSY 608
            ....:         ::...|::|.|..| .::...:|. |.....|.|.            |:|:
Mouse   569 YGPLKIVSQPLAFLEEDIREVLKEETGT-DIFLKEEDE-PAYKSCKQEHSASVKKVRKSLALESW 631

  Fly   609 FKANP-----YEDISQQELAKAKQMLTEEMEVVKERMAHGELPLDVYAQVWQECLGQVLYLPSQH 668
            .|..|     .||||..:   ::.:||..:.::.....|.
Mouse   632 DKEEPGTQLLTEDISDMQ---SENILTTSLLMIPLLEIHD------------------------- 668

  Fly   669 RYTRANLASKKDRLESAEKRLETNRRHMAKEAKRCGKIEKKLKILTGGYQARAQ---VLIKQLQD 730
              .|.||..:|..:.||.|....|::.......:..|:||.|       |:..:   |:..:.:|
Mouse   669 --NRCNLTPEKQDINSANKTYTLNKKRPNPNPCKAVKLEKSL-------QSNCEWETVVYGKTED 724

  Fly   731 TYGQIEQNSVSLSTF 745
            .....||....|||:
Mouse   725 QLIMTEQARRYLSTY 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	18/44 (41%)
		Myb_DNA-bind_6	11..71	CDD:290632	24/59 (41%)
		SANT_CDC5_II	56..108	CDD:212557	19/53 (36%)
		SANT	60..104	CDD:197842	17/45 (38%)
		Myb_Cef	397..648	CDD:288664	58/299 (19%)
Mybl1	NP_032677.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		SANT	35..83	CDD:197842	18/44 (41%)
		Myb_DNA-binding	35..81	CDD:278669	17/42 (40%)
		SANT	87..135	CDD:197842	18/73 (25%)
		Myb_DNA-binding	87..133	CDD:278669	17/45 (38%)
		SANT	139..186	CDD:197842	11/58 (19%)
		Myb_DNA-binding	139..184	CDD:278669	11/56 (20%)
		Transcriptional activation domain. /evidence=ECO:0000250	230..294		12/63 (19%)
		LMSTEN	242..285	CDD:285262	8/42 (19%)
		Negative regulatory domain. /evidence=ECO:0000250	297..552		58/324 (18%)
		Cmyb_C	485..646	CDD:286408	34/164 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810