DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cdc5 and cdc-5L

DIOPT Version :9

Sequence 1:	NP_001163313.1	Gene:	Cdc5 / 38062	FlyBaseID:	FBgn0265574	Length:	814	Species:	Drosophila melanogaster
Sequence 2:	NP_492303.1	Gene:	cdc-5L / 172639	WormBaseID:	WBGene00008386	Length:	755	Species:	Caenorhabditis elegans

Alignment Length:	830	Identity:	386/830 - (46%)
Similarity:	515/830 - (62%)	Gaps:	123/830 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPRIMIKGGVWRNTEDEILKAAVMKYGKNQWSRIASLLHRKSAKQCKARWYEWLDPSIKKTEWSR 65
            |.|::||||||:||||||||||:|||||||||||||||||||||||||||:|||||.||||||||
Worm     1 MVRVIIKGGVWKNTEDEILKAAIMKYGKNQWSRIASLLHRKSAKQCKARWFEWLDPGIKKTEWSR 65

  Fly    66 EEDEKLLHLAKLMPTQWRTIAPIIGRTAAQCLERYEYLLDQAQRKEDG-EDTMDDPRKLKPGEID 129
            |||||||||||||||||||||||:|||:||||||||:|||:||||.:| ::...:.|||||||||
Worm    66 EEDEKLLHLAKLMPTQWRTIAPIVGRTSAQCLERYEHLLDEAQRKAEGLDEEATETRKLKPGEID 130

  Fly   130 PNPETKPARPDPKDMDEDELEMLSEARARLANTQGKKAKRKAREKQLEEARRLATLQKRRELRAA 194
            |.||||||||||.|||:|||||||||||||||||||||||||||:||.:|||||:||||||:|||
Worm   131 PTPETKPARPDPIDMDDDELEMLSEARARLANTQGKKAKRKARERQLSDARRLASLQKRREMRAA 195

  Fly   195 GIGSGNRKRIK--GIDYNAEIPFEKRPAHGFYDTSEEHL------QKNEPDFNKMRQQDLDGELR 251
            |:....:.:.|  .|||:.||||||....||::.||:..      ||...|..|.|.::::.|:|
Worm   196 GLAFARKFKPKRNQIDYSEEIPFEKHVPAGFHNPSEDRYVVEDANQKAIEDHQKPRGREIEMEMR 260

  Fly   252 SEKEERERKRDKQKLKQRKENEVPTAMLQNMEPERKRSKLVLPTPQISDMELQQVVKLGRASEMA 316
            .|        |::|||:|||.....|:. |:: |:||||||||.|||||.||:|:||:|.||:..
Worm   261 RE--------DREKLKKRKEQGEADAVF-NIK-EKKRSKLVLPEPQISDRELEQIVKIGHASDSV 315

  Fly   317 KE-IAGESGIETTDALLADYSITPQ----VAATPRTPAPYTDRIMQEAQNMMALTHTETPLKGGL 376
            :: |.|.:    |..||.||:.:.:    .|.|.|||. ..|.:..|.:|:|||.:||:.|||||
Worm   316 RQYIDGTA----TSGLLTDYTESARANAVAARTMRTPM-LKDTVQLELENLMALQNTESALKGGL 375

  Fly   377 NTPLHESDF-SGVLPKAASIATPNTVI----ATPFRTQREGGAATPGGFQTPSSGALVPVKGAGG 436
            |||||||:. .||||.....||||||:    ||| .||.:...:|||||.||
Worm   376 NTPLHESELGKGVLPTPKVAATPNTVLHAIAATP-GTQSQFPGSTPGGFATP------------- 426

  Fly   437 ATGVVNTPAYVRDKLSINPEESMGVTETPAHYKNYQKQLKSTLRDGLSTLPAPRNDYEIVVPEQE 501
            |..|..||  .||::.||.|.:....|.           |::|:..|::||.|:||:|:|.|:.:
Worm   427 AGSVAATP--FRDQMRINEEIAGSALEQ-----------KASLKRALASLPTPKNDFEVVGPDDD 478

  Fly   502 ESERIETNSEPAVEDQAD-------VDARLLAEQEARRK-----RELEKRSQVIQRSLPRPTEVN 554
            |       .|.||||:::       .||...||.:|:|.     |.::.||||||||||:||:||
Worm   479 E-------VEGAVEDESNQDEDGWIEDASERAENKAKRNAENRVRNMKMRSQVIQRSLPKPTKVN 536

  Fly   555 TKILRPQSEKQNLTEQQQAEELIKHEMITMQLYDSVKDPVPGQSQHKLEQLQSYFKANPYEDISQ 619
                    |:........|::::|.||..:..:|....|                   |....|:
Worm   537 --------EQATRATNSSADDMVKAEMSKLLAWDVDNKP-------------------PSVIYSR 574

  Fly   620 QELAKAKQMLTEEMEVVKERMAHGELPLDVYAQVW---QECLGQVLYLPSQHRYTRANLASKKDR 681
            :||..|..::.:|.|...|          :.:.:|   ::|..:::.  |:.::||..:..::::
Worm   575 EELDAAADLIKQEAESGPE----------LNSLMWKVVEQCTSEIIL--SKDKFTRIAILPREEQ 627

  Fly   682 LESAEKRLETNRRHMAKEAKRCGKIEKKLKILTGGYQARAQVLIKQLQDTYGQIEQNSVSLSTFR 746
            :::.....:..|..|.:.|||..|:||||::..|||||....|.|:.|:...:||..::...||.
Worm   628 MKALNDEFQMYRGWMNQRAKRAAKVEKKLRVKLGGYQAIHDKLCKKYQEVTTEIEMANIEKKTFE 692

  Fly   747 FLGEQEAIAVPRRLESLQEDVRRQMDREKELQQKYASLVEERDSLYSQIE 796
            .|||.|..|:.:|:..||::|..|..|||:||:.|:.|..::..| ||||
Worm   693 RLGEHELKAINKRVGRLQQEVTTQETREKDLQKMYSKLSNKQWKL-SQIE 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cdc5	NP_001163313.1	SANT	8..56	CDD:197842	44/47 (94%)
		Myb_DNA-bind_6	11..71	CDD:290632	55/59 (93%)
		SANT_CDC5_II	56..108	CDD:212557	46/51 (90%)
		SANT	60..104	CDD:197842	40/43 (93%)
		Myb_Cef	397..648	CDD:288664	80/266 (30%)
cdc-5L	NP_492303.1	SANT	8..56	CDD:197842	44/47 (94%)
		Myb_DNA-bind_6	11..71	CDD:290632	55/59 (93%)
		SANT_CDC5_II	56..108	CDD:212557	46/51 (90%)
		SANT	60..104	CDD:197842	40/43 (93%)
		Myb_Cef	397..590	CDD:288664	78/253 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159240
Domainoid	1	1.000	331	1.000	Domainoid score	I610
eggNOG	1	0.900	-	-		E1_COG5147
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13291
Inparanoid	1	1.050	625	1.000	Inparanoid score	I472
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55711
OrthoDB	1	1.010	-	-		D195986at33208
OrthoFinder	1	1.000	-	-		FOG0002438
OrthoInspector	1	1.000	-	-		oto20281
orthoMCL	1	0.900	-	-		OOG6_102607
Panther	1	1.100	-	-	LDO	PTHR45885
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R188
SonicParanoid	1	1.000	-	-		X1623
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840