DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and MPDZ

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001362342.1	Gene:	MPDZ / 8777	HGNCID:	7208	Length:	2103	Species:	Homo sapiens

Alignment Length:	782	Identity:	149/782 - (19%)
Similarity:	256/782 - (32%)	Gaps:	254/782 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 AERKVGELHKLHRGQLPADAEYNYLEHAKRLELYG--IDLHRATDSNGKELQLGVSAVGLLVFQH 256
            |||...:|.:  ||.:..:.:.:.|:...:..|:.  :.|..:......::.:..||...:.:.|
Human    14 AERLQTKLRE--RGDVANEDKLSLLKSVLQSPLFSQILSLQTSVQQLKDQVNIATSATSNIEYAH 76

  Fly   257 SLRVNTFSWSKMVKVSFKRKDFFIQLRREPSE-NYDTLLGFGMSSHKHAKALWKSCVEHHSFFRL 320
            ...:     |..|..:.:.:.|.:    .|:. |.:.|.|.|:
Human    77 VPHL-----SPAVIPTLQNESFLL----SPNNGNLEALTGPGI---------------------- 110

  Fly   321 KRPHRLSRFLNISLGSKFYYSGR---TELQAVQESKQRGRIHKVF--VRSPSKRLLGAAGGVGTS 380
              ||               .:|:   .|...:.::..:||..:||  ::.||       ||:|.|
Human   111 --PH---------------INGKPACDEFDQLIKNMAQGRHVEVFELLKPPS-------GGLGFS 151

  Fly   381 ---------GSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRK 436
                     |..|....:...||.   :|.:|:......||.|  ..:..|..:|.::|.|:.:|
Human   152 VVGLRSENRGELGIFVQEIQEGSV---AHRDGRLKETDQILAI--NGQALDQTITHQQAISILQK 211

  Fly   437 AWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSD 501
            |    .|...:.:..|.:.|......|.|||               ..:||:   .|..|.....
Human   212 A----KDTVQLVIARGSLPQLVSPIVSRSPS---------------AASTIS---AHSNPVHWQH 254

  Fly   502 LITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRH 566
            :.||.|..|..| .||.:.||  .:..|.|..::|...||: ..|:|.||.:|.|...|:.|:..
Human   255 METIELVNDGSG-LGFGIIGG--KATGVIVKTILPGGVADQ-HGRLCSGDHILKIGDTDLAGMSS 315

  Fly   567 EQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLL 631
            |||..::|.|.::....:......:|:||..
Human   316 EQVAQVLRQCGNRVKLMIARGAIEERTAPTA---------------------------------- 346

  Fly   632 LLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRY-------RDISPYDCTRVSLVNSL 689
                                    |.||.:..|.:.|:.|.       .:...:|   |.|..::
Human   347 ------------------------LGITLSSSPTSTPELRVDASTQKGEESETFD---VELTKNV 384

  Fly   690 TGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGR-QKCHQ 753
            .|       :.:.|.|...::.:...|....:.|        :||       .|...|| |...|
Human   385 QG-------LGITIAGYIGDKKLEPSGIFVKSIT--------KSS-------AVEHDGRIQIGDQ 427

  Fly   754 YWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNL 818
            ...|.|..||   ||:.:...|....||..|....:.:...::..:...:.:.......|.:.::
Human   428 IIAVDGTNLQ---GFTNQQAVEVLRHTGQTVLLTLMRRGMKQEAELMSREDVTKDADLSPVNASI 489

  Fly   819 FLEFTER----VRAARNRTLL--------------QEIEESLKQ--------VRLMDADADA--- 854
            ..|..|:    :.:.||..:|              :|||::.||        .|:|..:.:.
Human   490 IKENYEKDEDFLSSTRNTNILPTEEEGYPLLSAEIEEIEDAQKQEAALLTKWQRIMGINYEIVVA 554

  Fly   855 -----DENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDT 914
                 .||.||          |.:.|     :|..|..|.:..|      ...:|.:|.|...|.
Human   555 HVSKFSENSGL----------GISLE-----ATVGHHFIRSVLP------EGPVGHSGKLFSGDE 598

  Fly   915 AL 916
            .|
Human   599 LL 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	8/39 (21%)
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785	8/39 (21%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	13/96 (14%)
		FA	333..369	CDD:285894	8/40 (20%)
		PDZ_signaling	502..589	CDD:238492	27/86 (31%)
		Y_phosphatase	666..955	CDD:278528	55/293 (19%)
		PTPc	668..955	CDD:238006	55/291 (19%)
MPDZ	NP_001362342.1	PDZ_signaling	2019..2102	CDD:238492
		L27_2	6..63	CDD:312549	9/50 (18%)
		PDZ_signaling	139..221	CDD:238492	22/97 (23%)
		PDZ_signaling	257..334	CDD:238492	27/80 (34%)
		PDZ	374..463	CDD:214570	25/116 (22%)
		PDZ_signaling	560..629	CDD:238492	15/62 (24%)
		PDZ_signaling	698..784	CDD:238492
		PDZ_signaling	1006..1076	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1140
		PDZ_signaling	1149..1240	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1278..1324
		PDZ	1347..1433	CDD:214570
		PDZ_signaling	1514..1593	CDD:238492
		MPDZ_u10	1595..1659	CDD:374710
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1600..1645
		PDZ	1660..1744	CDD:214570
		PDZ_signaling	1758..1836	CDD:238492
		PDZ_signaling	1893..1978	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910