DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and PTP1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_010051.1	Gene:	PTP1 / 851368	SGDID:	S000002389	Length:	335	Species:	Saccharomyces cerevisiae

Alignment Length:	335	Identity:	99/335 - (29%)
Similarity:	140/335 - (41%)	Gaps:	76/335 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   663 KPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAV--NRYIATQGPLASTTTDF 725
            :|.|..:|||.:|.||:..||.|......|||||:||.:.:||.::  ..|||||||...|...|
Yeast    49 EPRNDARNRYVNIMPYERNRVHLKTLSGNDYINASYVKVNVPGQSIEPGYYIATQGPTRKTWDQF 113

  Fly   726 WRMVQQE---SSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFRE 787
            |:|....   .:.::||:|.::|..|:||:||||..|.:      .:||..|:.....|:....:
Yeast   114 WQMCYHNCPLDNIVIVMVTPLVEYNREKCYQYWPRGGVD------DTVRIASKWESPGGANDMTQ 172

  Fly   788 FVLKDKHEQRHIHHMQ--YLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDA 850
            |....|.|..::|.::  |........|:||                     :...:|.|.....
Yeast   173 FPSDLKIEFVNVHKVKDYYTVTDIKLTPTDP---------------------LVGPVKTVHHFYF 216

  Fly   851 DADADENGGLMRERKCAASNGATPEDETPV---STSVHQCISAANPPVIVHCSAGIGRTGVLI-- 910
            |...|.|               .||:..|:   ....|...|..| |:|||||||:||||..|
Yeast   217 DLWKDMN---------------KPEEVVPIMELCAHSHSLNSRGN-PIIVHCSAGVGRTGTFIAL 265

  Fly   911 --LMDTALALMEARE---------PVYPLD----IVRTMRDQRACMVQNVSQYRFVCECICAAYM 960
              ||...|......|         ..|..|    ||..:|.||..|||...|:.|:..  .|.|:
Yeast   266 DHLMHDTLDFKNITERSRHSDRATEEYTRDLIEQIVLQLRSQRMKMVQTKDQFLFIYH--AAKYL 328

  Fly   961 KISRSSAAIN 970
                :|.::|
Yeast   329 ----NSLSVN 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528	94/315 (30%)
		PTPc	668..955	CDD:238006	93/313 (30%)
PTP1	NP_010051.1	COG5599	1..335	CDD:227886	99/335 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	133	1.000	Domainoid score	I1104
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000