DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and FRMD5

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_116281.2	Gene:	FRMD5 / 84978	HGNCID:	28214	Length:	570	Species:	Homo sapiens

Alignment Length:	701	Identity:	179/701 - (25%)
Similarity:	289/701 - (41%)	Gaps:	163/701 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RLRGGGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLF 79
            ||..|      ..::.:|:...||..|||..:|..|::.|||..|.|.:..:|.|.|:||||:.|
Human     4 RLMSG------SSRSLEREYSCTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRF 62

  Fly    80 PQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPL-LEFRVKFFVSDPSRLQEEFTRYQFYLQIKRN 143
            .. |.....|::..|...||..|      ..|. :.|||||:.:||:.|:||.|||..:|||||:
Human    63 VD-PDKQRHWLEFTKSVVKQLRS------QPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRD 120

  Fly   144 ILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLH-RG 207
            :..|:|.|.::...|||:|.:|:|:||:::.:|..||.|..|.....:.:.|||:.|:||.. .|
Human   121 LYHGRLLCKTSDAALLAAYILQAEIGDYDSGKHPEGYSSKFQFFPKHSEKLERKIAEIHKTELSG 185

  Fly   208 QLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVS 272
            |.||.:|.|:|..|:.||.||:|.|...|.:|....|..:..|.:|.|.:.||:...|:::.|:.
Human   186 QTPATSELNFLRKAQTLETYGVDPHPCKDVSGNAAFLAFTPFGFVVLQGNKRVHFIKWNEVTKLK 250

  Fly   273 FKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISL--- 334
            |:.|.|::.:.::  |....:|.:...:.:..|.|||..:|:.:|::|::..::....:.:|
Human   251 FEGKTFYLYVSQK--EEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFK 313

  Fly   335 GSKFYYSGRTELQAVQES----KQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSE 395
            ||:|.||||...:.::.|    ::...||:                      :|..|      |.
Human   314 GSRFRYSGRVAKEVMESSAKIKREPPEIHR----------------------AGMVP------SR 350

  Fly   396 SANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRR 460
            |..|..:|                        ....|:||....        .:.:..:|.....
Human   351 SCPSITHG------------------------PRLSSVPRTRRR--------AVHISIMEGLESL 383

  Fly   461 FESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDL 525
            .:||..:|:    .|..|....||     .|...:.:|...:..|   |||
Human   384 RDSAHSTPV----RSTSHGDTFLP-----HVRSSRTDSNERVAVI---ADE-------------- 422

  Fly   526 SLPVQVSKVVPHTPADRCTPR-VCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVR 589
                      .::|||...|. |.|....||:..|.::|          ..|..:...|
Human   423 ----------AYSPADSVLPTPVAEHSLELMLLSRQING----------ATCSIEEEKE------ 461

  Fly   590 PQRSAPLLLEEEPLYQYV---------PESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQ 645
            .:.|.|...|.|.|...:         ||.:::...       .|....|||::.||....||.
Human   462 SEASTPTATEVEALGGELRALCQGHSGPEEEQVNKF-------VLSVLRLLLVTMGLLFVLLLL- 518

  Fly   646 YELMYRKNPDLAIT---EARKPANAPKNRYRDISP----YDCTRVSLVNSL 689
              |:.....||.|.   :.|:.....:..|:...|    :.|...|:|:.|
Human   519 --LIILTESDLDIAFFRDIRQTPEFEQFHYQYFCPLRRWFACKIRSVVSLL 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	80/198 (40%)
		FERM_N	38..102	CDD:286467	24/63 (38%)
		FERM_M	125..232	CDD:278785	46/107 (43%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	25/93 (27%)
		FA	333..369	CDD:285894	11/42 (26%)
		PDZ_signaling	502..589	CDD:238492	16/87 (18%)
		Y_phosphatase	666..955	CDD:278528	6/28 (21%)
		PTPc	668..955	CDD:238006	6/26 (23%)
FRMD5	NP_116281.2	B41	19..210	CDD:214604	80/197 (41%)
		FERM_C_FRMD3_FRMD5	191..295	CDD:270013	31/105 (30%)
		Interaction with ROCK1. /evidence=ECO:0000269\|PubMed:25448675	308..353		15/72 (21%)
		FA	309..354	CDD:370090	15/72 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	344..367		8/52 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..407		8/30 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910