DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Kalrn

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038944566.1	Gene:	Kalrn / 84009	RGDID:	621865	Length:	2989	Species:	Rattus norvegicus

Alignment Length:	1137	Identity:	218/1137 - (19%)
Similarity:	358/1137 - (31%)	Gaps:	392/1137 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 DKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWV 90
            ||....||.      |..:.|..:::        |||.|| |.|.|:|      .:|..|   |:
  Rat   289 DKLHSTRQH------LHQMWHVRKLK--------LDQCFQ-LRLFEQD------AEKMFD---WI 329

  Fly    91 DAQKQ-FKKQCSSVSLDNDAVPLLEFRVKFF--------------VSDPSRLQE--EFTRYQFYL 138
            ...|: |.:..:.:.:.......|:.:...|              :|..|||.|  .:...|. .
  Rat   330 SHNKELFLQSHTEIGVSYQHALDLQTQHNHFAMNSMNAYVNINRIMSVASRLSEAGHYASQQI-K 393

  Fly   139 QIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPG--YLSGMQLLC------------- 188
            ||...:       ....:...|:...:|.:...:|:.||..  :|||:...|
  Rat   394 QISTQL-------DQEWKSFAAALDERSTILAMSAVFHQKAEQFLSGVDAWCKMCSEGGLPSEMQ 451

  Fly   189 -------------DQTTEAERKVGE-----LHKLHRGQLPADAE-----YNY------------- 217
                         :|.|:|..:|.:     |..|.|...|.::|     .||
  Rat   452 DLELAIHHHQSLYEQVTQAYTEVSQDGKALLDVLQRPLSPGNSESLTATANYSKAVHQVLDVVHE 516

  Fly   218 -LEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSF-------- 273
             |.|.:|||  .|..||....: :.||       |.|||..:: ....|.:....:|
  Rat   517 VLHHQRRLE--SIWQHRKVRLH-QRLQ-------LCVFQQDVQ-QVLDWIENHGEAFLSKHTGVG 570

  Fly   274 ----------KRKDFFIQLRREPSENYDTLL----GFGMSSHKHAKALWKSC----VEHHSFFRL 320
                      ||.|.|.::.:....|.|.||    ....:.....:.::|:.    |....|.|.
  Rat   571 KSLHRARALQKRHDDFEEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYKAARHLEVRIQDFVRR 635

  Fly   321 KRPHRLSRFLNISL--GSKFYYSGRTELQ-------------AVQESKQRGRIHKVFVRSPSKRL 370
            ....:|...:::|.  .:|..::...:||             ||||      :.|.|.:..:..|
  Rat   636 VEQRKLLLDMSVSFHTHTKELWTWMEDLQKEVLEDVCADSVDAVQE------LIKQFQQQQTATL 694

  Fly   371 LGAAGGVGTSGSSGGTPMQQ-HSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKE----- 429
            ......:    ..|...:|| .|...|.     |:|..|.. ..::....||.:.::..|
  Rat   695 DATLNVI----KEGEDLIQQLRSAPPSL-----GEPTEARD-SAVSNNKTPHSSSISHIESVLQQ 749

  Fly   430 ---ADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADA- 490
               |.....:.:.::..:.||.|.:...||.|                       :..|...||
  Rat   750 LDDAQVQMEELFHERKIKLDIFLQLRIFEQYT-----------------------IEVTAELDAW 791

  Fly   491 ---VGHQQPESGSDLITI---RLQADEQGRYGFN------VKGGVDLS---LPVQVSKVVPHTPA 540
               :..|..:..::.:|:   |||...:.:...|      ::.|.||.   :.||.|.:
  Rat   792 NEDLLRQMNDFNTEDLTLAEQRLQRHTERKLAMNNMTFEVIQQGQDLHQYIMEVQASGI------ 850

  Fly   541 DRCTPRVCEGD------------------EVLMINGRDVH-------GLRH-----EQVVAMIRD 575
                ..:||.|                  ..|.:|....|       .|||     :||:..||
  Rat   851 ----ELICEKDVDLAAQVQELLEFLHEKQHELELNAEQTHKRLEQCLQLRHLQAEVKQVLGWIR- 910

  Fly   576 CRHQASGELLLTVRPQRSAPL-----LLEEEPLYQYVPES-----DEIGSHSNLL---------- 620
                 :||.:|......::.|     |..|...:|...||     ....:|.:.|
  Rat   911 -----NGESMLNASLVNASSLSEAEQLQREHEQFQLAIESLFHATSLQKTHQSALQVQQKAEALL 970

  Fly   621 -----DGDAL----------FTQSLLLLSDGL----ASGA----------LLAQYELMYRKNPDL 656
                 |.||:          :.|.:|.:.|.|    ||.|          :|...|..||::.|.
  Rat   971 QAGHYDADAIRECAEKVALHWQQLMLKMEDRLKLVNASVAFYKTSEQVCSVLESLEQEYRRDEDW 1035

  Fly   657 AITEARKPANAPKNRYRDISPY-------------DCTRVSLVNSLTGDYINANYVNMEIPGGAV 708
            .   ..:....|......:.|.             .||.......:...||:.|  |:.:|..|.
  Rat  1036 C---GGRDKLGPAAEMDHVIPLLSKHLEQKEAFLKACTLARRNAEVFLKYIHRN--NVSMPSVAS 1095

  Fly   709 NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQY------------W-PVTGE 760
            :    |:||..........::|:|:.  ::...|:.:....:|.||            | ..|||
  Rat  1096 H----TRGPEQQVKAILSELLQRENR--VLHFWTLKKRRLDQCQQYVVFERSAKQALDWIQETGE 1154

  Fly   761 ---ELQLAEGFSVRCLSEKPDETGSFVFREFVLKDK-----------HEQRHIHHMQYLAWPDHC 811
               ....:.|.:.....|...|.|.|.......|:|           .|:.|||..:...|
  Rat  1155 YYLSTHTSTGETTEETQELLKEYGEFRVPAKQTKEKVKLLIQLADSFVEKGHIHATEIRKW---- 1215

  Fly   812 VPSDPNLFLEFTER-------------VRAARNRTL-LQEIEESL--KQVRLMDADADADENGGL 860
            |.:....:.:|:.|             |....|:.| |..|..||  ::|:|.||:.:.:|
  Rat  1216 VTTVDKHYRDFSLRMGKYRYTLEKALGVNTEDNKDLELDIIPASLSDREVKLRDANHEVNE---- 1276

  Fly   861 MRERKCAASN----GATPEDETPVSTSVHQCI 888
             .:||.|...    ....:.|......:|:|:
  Rat  1277 -EKRKSARKKEFIMAELLQTEKAYVRDLHECL 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	52/265 (20%)
		FERM_N	38..102	CDD:286467	16/64 (25%)
		FERM_M	125..232	CDD:278785	33/160 (21%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	22/119 (18%)
		FA	333..369	CDD:285894	10/50 (20%)
		PDZ_signaling	502..589	CDD:238492	27/128 (21%)
		Y_phosphatase	666..955	CDD:278528	56/283 (20%)
		PTPc	668..955	CDD:238006	56/281 (20%)
Kalrn	XP_038944566.1	SEC14	42..180	CDD:214706
		SPEC	193..413	CDD:238103	31/155 (20%)
		SPEC	314..539	CDD:238103	48/245 (20%)
		SPEC	540..769	CDD:238103	43/252 (17%)
		SPEC	894..1132	CDD:238103	49/254 (19%)
		SPEC	1138..1238	CDD:197544	19/103 (18%)
		RhoGEF	1287..1457	CDD:238091	3/21 (14%)
		PH1_Kalirin_Trio_like	1464..1586	CDD:270060
		SH3_Kalirin_1	1652..1711	CDD:212786
		SH3-RhoG_link	1708..1892	CDD:406906
		RhoGEF	1935..2104	CDD:395496
		PH2_Kalirin_Trio_p63RhoGEF	2109..2243	CDD:270061
		SH3_Kalirin_2	2327..2385	CDD:212787
		Ig strand A	2466..2469	CDD:409353
		I-set	2474..2568	CDD:400151
		Ig strand A'	2482..2485	CDD:409353
		Ig strand B	2491..2498	CDD:409353
		Ig strand C	2504..2512	CDD:409353
		Ig strand C'	2515..2517	CDD:409353
		Ig strand D	2523..2532	CDD:409353
		Ig strand E	2534..2538	CDD:409353
		Ig strand F	2547..2555	CDD:409353
		Ig strand G	2558..2568	CDD:409353
		FN3	2572..2663	CDD:238020
		STKc_Kalirin_C	2693..2940	CDD:271017
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910