DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and ptpn21

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_005169845.1	Gene:	ptpn21 / 799627	ZFINID:	ZDB-GENE-080102-4	Length:	1204	Species:	Danio rerio

Alignment Length:	1286	Identity:	289/1286 - (22%)
Similarity:	466/1286 - (36%)	Gaps:	430/1286 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 GPELARDKK-TPQRQQCVT--VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQ 81
            |.:|.|.:: |...:.|:.  :..|:.....|.:...:.|.|.|:.|.|.|||.|..||.|.:..
Zfish     6 GLKLKRTRRYTVSSKSCLVTRIQLLNGEYVEFTLSVESTGQECLEAVAQRLELREITYFSLWYYN 70

  Fly    82 KPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILL 146
            |... .||:|.:|..|||.....|:    |.:.|.|.|:|...::||:|.||||:|||:|:::|.
Zfish    71 KQNQ-QRWIDLEKPLKKQLDKYGLE----PTVYFGVVFYVCTVTQLQQEITRYQYYLQLKKDVLE 130

  Fly   147 GKLPCSSNTQCLLASYTVQSELGDFNALEHQPG----YLSGMQLLCDQ--TTEAERKVGELHKLH 205
            ||:|||......|||..||::|||||..:.|..    .|..|..:.|:  ..||.:||..|::.:
Zfish   131 GKIPCSIEQAIHLASLAVQADLGDFNRYDSQEFLQKIVLFPMPWIQDERVVEEATQKVTMLYQNY 195

  Fly   206 RGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLV-FQHSLRVNTFSWSKMV 269
            ||....:||..|::..:::|.||.:..:|.||...::.:|....|:.| .::......|.|:.:.
Zfish   196 RGLSAPEAELLYMQEVEKIEGYGEESIQAKDSQATDVIIGSCLDGIFVKHKNGKAPLIFRWNDIN 260

  Fly   270 KVSFKRKDFFIQL-RREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR----------- 322
            .::..:..|.::| .:|.:..:.|   ..|.:.|:...:|   :..|.|:::..
Zfish   261 NMTHNKSFFALELANKEDTIQFQT---EDMETSKYVCRMW---LARHKFYKINNSSLEPSCDPNS 319

  Fly   323 --PHR------LSRFLNISLGSKFYYSGRTELQAVQESKQR----------------------GR 357
              |.|      ..||..:|..|.....|:|:...|...::|                      |.
Zfish   320 EGPQRSILSLSFPRFPALSRLSVPADKGQTQPAPVNPVRRRSSTRMSLPKPQPYMMPPQMHFNGH 384

  Fly   358 IHKVFVRSPSKRLLGAAGG--VGTSGSSGGTPMQQHSG---------SESANSHNNGK------P 405
            .::.:..|.....:....|  ..:..|...:| .:::|         ::|.:|.||.:      |
Zfish   385 YNEPYTSSQDNLYINNQNGFYYHSQTSLDRSP-HEYNGRIRNGSVYSAQSTSSLNNPQHYLQPSP 448

  Fly   406 AGAGTILTITKTSRPH-------------------DNKVTSKEADSMPRKAWEQQSDEYDIQLDV 451
            ..:...:|.:...||.                   |.:...::.:.:|  |.|:||.... .|::
Zfish   449 MSSNPSITGSDLMRPDYVPSHRHSALIPPSYRATPDYETVMRQKNMIP--AAERQSHSMR-NLNI 510

  Fly   452 G-----------FIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVG------------- 492
            |           ...|...|...|...|....||....||...||.....||
Zfish   511 GNSYAYSRPDPLVYSQPEIREHGAGQYPFHLNYSFHSPSPYPYPTERRPVVGAVSVPELTNVQLQ 575

  Fly   493 -------------------------HQQP--------------ESGSDLITIRLQADEQG----- 513
                                     |.:|              .|..||||.|:....|.
Zfish   576 QAQEYPPPNIIRNQVYWPPPPYPYPHPRPANSTPDLSRHLYVSSSNPDLITRRVHHSVQTFQEDS 640

  Fly   514 ---------------------------------RYGF--------------------------NV 519
                                             .||.                          :.
Zfish   641 LPVAHSLQEVSEPLVTARRPHMHKRNSIEIAGLAYGLENMRLKERKVSASAADTPPPVAAAVPHA 705

  Fly   520 KGGVDLSLPVQVSK----------------------VVPHTPAD---------RCTPR---VCEG 550
            ..|.|:::.::|||                      ::.|:..:         |.||:   ...|
Zfish   706 ASGSDINVVLEVSKPEDVGIKEDVFYGHKKSLSDATMLVHSSGEEEEFEDDSGRHTPQSQDAVSG 770

  Fly   551 DEVLMIN-GRDV-----HGLRHEQVVAMIRDCRHQA----------------------------- 580
            .|..|.: ||.:     :...|.....:.....:||
Zfish   771 PEHPMTSLGRSLGDPPAYPFSHSMETVLTSPPAYQAHSIMQKAEDVGPLPPLREPGLMMPSVSEG 835

  Fly   581 --SGELL----LTVRPQRSAP----------------------------------LLLEEEPLYQ 605
              ||.|.    ::.||....|                                  |.|...||
Zfish   836 DLSGRLRKNRDISKRPVSDVPPGRRNIDGLPPAGMKKGRSEVKKVGPLKLAALNGLTLSRIPL-- 898

  Fly   606 YVPE--SDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAP 668
              |:  .|:..|.||        .:....|...|..|.:..:||.:.:|.|:...:.|:.|.|..
Zfish   899 --PDDGKDDPESASN--------DERCKFLEQRLDQGMVFTEYEQVPKKRPNSEYSIAQMPENND 953

  Fly   669 KNRYRDISPYDCTRVSLV---NSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQ 730
            :||::|:.|||.|||.||   .:.|| ||||:::.:.:.|...: |||:||||:||..|||:||.
Zfish   954 RNRFQDVLPYDDTRVELVPTKENNTG-YINASHIRVTVRGKEWS-YIASQGPLSSTCQDFWQMVW 1016

  Fly   731 QESSHLLVMLTTVMESGRQKCHQYWP--------VTGEELQLAEGFSVRCLSEKPDETGSFVFRE 787
            ::...::.|:|...|.||:|..:|||        ||....::...|          .|.|..:..
Zfish  1017 EQGVSIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRF----------RTDSGCYAT 1071

  Fly   788 FVLKDKH----EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLM 848
            ..||.||    ::|.:.|:||..||||..|.|...||.:.|.:::.|..|
Zfish  1072 TGLKIKHLLTGQERTVWHLQYTDWPDHGCPEDFKGFLSYLEEIQSVRRHT--------------- 1121

  Fly   849 DADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMD 913
                                ::.:.|::              .|.||:||||||:|||||:||.:
Zfish  1122 --------------------NSSSDPKN--------------TNLPVLVHCSAGVGRTGVVILSE 1152

  Fly   914 TALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAYMKISR 964
            ..:|.:|..|.:....::..:|.||..|||.:|||.|:.: :...::|.||
Zfish  1153 IMIACLEHNEMLDVPTVLNLLRQQRMMMVQTLSQYTFIYK-VLIQFLKNSR 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	73/204 (36%)
		FERM_N	38..102	CDD:286467	22/63 (35%)
		FERM_M	125..232	CDD:278785	44/112 (39%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	19/95 (20%)
		FA	333..369	CDD:285894	8/57 (14%)
		PDZ_signaling	502..589	CDD:238492	27/225 (12%)
		Y_phosphatase	666..955	CDD:278528	96/303 (32%)
		PTPc	668..955	CDD:238006	95/301 (32%)
ptpn21	XP_005169845.1	B41	26..220	CDD:214604	72/198 (36%)
		FERM_N	27..90	CDD:286467	22/63 (35%)
		FERM_M	111..220	CDD:278785	44/108 (41%)
		FERM_C_PTPN14_PTPN21	217..307	CDD:270009	19/95 (20%)
		PTPc	927..1196	CDD:214550	102/330 (31%)
		PTPc	953..1196	CDD:238006	95/304 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810