DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and TLN1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_006280.3	Gene:	TLN1 / 7094	HGNCID:	11845	Length:	2541	Species:	Homo sapiens

Alignment Length:	1127	Identity:	214/1127 - (18%)
Similarity:	365/1127 - (32%)	Gaps:	328/1127 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FRLRGGGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLL 78
            :.||.|.....|.|:.|     :.:..||....|..::.....:::|..:...:.::..|.:.|:
Human    71 YMLRNGDTMEYRKKQRP-----LKIRMLDGTVKTIMVDDSKTVTDMLMTICARIGITNHDEYSLV 130

  Fly    79 ------------------------------FPQK--PGDVVRWVDAQKQFKKQCSSVSLDNDAVP 111
                                          ..||  ..|.:.|:|..:..::|    .::.....
Human   131 RELMEEKKEEITGTLRKDKTLLRDEKKMEKLKQKLHTDDELNWLDHGRTLREQ----GVEEHETL 191

  Fly   112 LLEFRVKFFVS-------DPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELG 169
            ||  |.|||.|       ||.:|.      ..|:|.:.:||.|..|.|.:..|..|.:..|.:.|
Human   192 LL--RRKFFYSDQNVDSRDPVQLN------LLYVQARDDILNGSHPVSFDKACEFAGFQCQIQFG 248

  Fly   170 DFNALEHQPGYLSGMQLLCDQ--TTEAERKVGELHKLHRGQL-PADAEYNYLEHAKRLELYGIDL 231
            ..|..:|:.|:|.....|..:  ..:.|||:.:.|| :.||: ..:|:..|::.|:.|:.||:..
Human   249 PHNEQKHKAGFLDLKDFLPKEYVKQKGERKIFQAHK-NCGQMSEIEAKVRYVKLARSLKTYGVSF 312

  Fly   232 HRATDS-NGKE----LQLGVSAVGLL--------VFQHSLRVNTFSWSKMVKVSF-----KRKDF 278
            ....:. .||.    ..||::...::        |.|.....|...|:...| ||     ..:|.
Human   313 FLVKEKMKGKNKLVPRLLGITKECVMRVDEKTKEVIQEWNLTNIKRWAASPK-SFTLDFGDYQDG 376

  Fly   279 FIQLRREPSENYDTLLG---------------FGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSR 328
            :..::....|....|:.               ||:...:.:..|..|.....|
Human   377 YYSVQTTEGEQIAQLIAGYIDIILKKKKSKDHFGLEGDEESTMLEDSVSPKKS------------ 429

  Fly   329 FLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSG 393
                           |.||  |:..:.|::....|..|:....||:|.......|.....||.:.
Human   430 ---------------TVLQ--QQYNRVGKVEHGSVALPAIMRSGASGPENFQVGSMPPAQQQITS 477

  Fly   394 SESANSH----NNGKPAGAGTILTITKTSRPHDNKVTSKEADSMP-------RKAW-EQQSDE-- 444
            .:....|    .:.:.|..|||.:..:..:.  .:.|..:.|::|       .||| :.:.||
Human   478 GQMHRGHMPPLTSAQQALTGTINSSMQAVQA--AQATLDDFDTLPPLGQDAASKAWRKNKMDESK 540

  Fly   445 YDIQLDVGFIEQCTRRFES-ASPSPMPPAYSS------------------------------GQH 478
            ::|...|..|...|....: .:..|....|::                              |..
Human   541 HEIHSQVDAITAGTASVVNLTAGDPAETDYTAVGCAVTTISSNLTEMSRGVKLLAALLEDEGGSG 605

  Fly   479 SPIL-----LPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPH- 537
            .|:|     |...:::.:...||.|......: |||  .|..|   :...:|...:..|...||
Human   606 RPLLQAAKGLAGAVSELLRSAQPASAEPRQNL-LQA--AGNVG---QASGELLQQIGESDTDPHF 664

  Fly   538 -TPADRCTPRVCEGDEVLMINGRDV------HGLRHEQVVAMIRDCRHQASGELLLT--VRPQRS 593
             ....:....|......|::..:.|      .||: .||:|....|....|..:..|  |.|..|
Human   665 QDALMQLAKAVASAAAALVLKAKSVAQRTEDSGLQ-TQVIAAATQCALSTSQLVACTKVVAPTIS 728

  Fly   594 APL----LLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALL-AQYELMYRKN 653
            :|:    |:|...|.....|.....|.:...||.       ||...|.|:.|:. |..||:..
Human   729 SPVCQEQLVEAGRLVAKAVEGCVSASQAATEDGQ-------LLRGVGAAATAVTQALNELLQH-- 784

  Fly   654 PDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRYIATQGPL 718
                 .:|......|..||...:....|....:.|..||            .|.:.|....   |
Human   785 -----VKAHATGAGPAGRYDQATDTILTVTENIFSSMGD------------AGEMVRQARI---L 829

  Fly   719 ASTTTDFWRMVQQ--------ESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSE 775
            |..|:|....::.        |:|..|:....::..          .|.:.::.|:|.:....||
Human   830 AQATSDLVNAIKADAEGESDLENSRKLLSAAKILAD----------ATAKMVEAAKGAAAHPDSE 884

  Fly   776 KPDETGSFVFREF--------------VLKDKHEQRHIH--------HMQYLAWPDHCVPSDPNL 818
            :..:.    .||.              .:|.|..||..|        ..|.:|...|...
Human   885 EQQQR----LREAAEGLRMATNAAAQNAIKKKLVQRLEHAAKQAAASATQTIAAAQHAAS----- 940

  Fly   819 FLEFTERVRAARNRTLLQEIEESLKQVRLM-------DADADAD--------------ENGGLMR 862
                |.:..|.....|:|..:...:|:.|:       .|..|:.              :.||.|
Human   941 ----TPKASAGPQPLLVQSCKAVAEQIPLLVQGVRGSQAQPDSPSAQLALIAASQSFLQPGGKM- 1000

  Fly   863 ERKCAASNGATP--EDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPV 925
               .||:..:.|  :|:             |:...:..|:..:|..    |.:...|..:|:|..
Human  1001 ---VAAAKASVPTIQDQ-------------ASAMQLSQCAKNLGTA----LAELRTAAQKAQEAC 1045

  Fly   926 YPLDIVRTMRDQRACMVQNVSQ 947
            .||::     |....:|||:.:
Human  1046 GPLEM-----DSALSVVQNLEK 1062

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	51/238 (21%)
		FERM_N	38..102	CDD:286467	12/95 (13%)
		FERM_M	125..232	CDD:278785	30/109 (28%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	21/126 (17%)
		FA	333..369	CDD:285894	7/35 (20%)
		PDZ_signaling	502..589	CDD:238492	20/96 (21%)
		Y_phosphatase	666..955	CDD:278528	59/335 (18%)
		PTPc	668..955	CDD:238006	59/333 (18%)
TLN1	NP_006280.3	FERM_f0	4..83	CDD:293120	3/11 (27%)
		B41	88..313	CDD:214604	51/237 (22%)
		FERM_N	90..186	CDD:286467	12/99 (12%)
		FERM_M	204..313	CDD:278785	32/115 (28%)
		Interaction with LAYN. /evidence=ECO:0000250\|UniProtKB:P54939	280..435		32/185 (17%)
		FERM_C_Talin	309..400	CDD:269973	15/91 (16%)
		Talin_middle	491..652	CDD:286254	30/168 (18%)
		I_LWEQ	607..>759	CDD:302998	35/158 (22%)
		I_LWEQ	822..>912	CDD:302998	16/106 (15%)
		talin-RS	1043..1197	CDD:213393	7/25 (28%)
		talin-RS	1204..1351	CDD:213393
		Interaction with SYNM. /evidence=ECO:0000269\|PubMed:18342854	1327..1948
		Interaction with VCL and F-actin. /evidence=ECO:0000250\|UniProtKB:P26039	1359..1659
		talin-RS	1654..1826	CDD:213393
		VBS	1849..1973	CDD:286057
		ILWEQ	2336..2532	CDD:214607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910