DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Tln2

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_006511496.1	Gene:	Tln2 / 70549	MGIID:	1917799	Length:	2559	Species:	Mus musculus

Alignment Length:	1011	Identity:	199/1011 - (19%)
Similarity:	354/1011 - (35%)	Gaps:	246/1011 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FRLRGGGPELARDKKTPQR----QQCVTVLFLDD--------ITHTFRI---------------- 50
            :.||.|.....:.|:.||:    ...|..:.:||        :|...||
Mouse    75 YMLRNGDILEYKKKQRPQKIRMLDGSVKTVMVDDSKTVGELLVTICSRIGITNYEEYSLIQETIE 139

  Fly    51 EKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEF 115
            ||:.:|:..|.:....|. .||....|.......|.:.|:|..:.|::|    .:|.:...||
Mouse   140 EKKEEGTGTLKKDRTLLR-DERKMEKLKAKLHTDDDLNWLDHSRTFREQ----GVDENETLLL-- 197

  Fly   116 RVKFFVS-------DPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNA 173
            |.|||.|       ||.:|.      ..|:|.:.:||.|..|.|....|....:..|.:.|....
Mouse   198 RRKFFYSDQNVDSRDPVQLN------LLYVQARDDILNGSHPVSFEKACEFGGFQAQIQFGPHVE 256

  Fly   174 LEHQPGYLSGMQLLCDQTTE---AERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRAT 235
            .:|:||:|...:.|..:..:   ||:::.:.||........:|:..|::.|:.|..||:......
Mouse   257 HKHKPGFLDLKEFLPKEYIKQRGAEKRIFQEHKNCGEMSEIEAKVKYVKLARSLRTYGVSFFLVK 321

  Fly   236 DSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQ-----LRREPSENYDTLLG 295
            :....:.:|....:|:            :...:::|..|.|:...:     ::|..:......|.
Mouse   322 EKMKGKNKLVPRLLGI------------TKDSVMRVDEKTKEVLQEWPLTTVKRWAASPKSFTLD 374

  Fly   296 FGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSK-----FYYSGRTELQAVQES--- 352
            ||.....:...   ...|.....:|     ::.:::|.|..|     |...|..|...::||
Mouse   375 FGEYQESYYSV---QTTEGEQISQL-----IAGYIDIILKKKQSKDRFGLEGDEESTMLEESVSP 431

  Fly   353 KQRGRIHKVFVRSPSKRLLG--AAGGVGTSGSSG---------GTPMQQHSGSESANSH----NN 402
            |:...:.:.|.|: .|...|  |...|..|||||         .:|.||....:....|    .:
Mouse   432 KKSTILQQQFNRT-GKAEHGSVALPAVMRSGSSGPETFNVGSMPSPQQQVMVGQMHRGHMPPLTS 495

  Fly   403 GKPAGAGTILTITKTSRPHDNKVTSKEADSMP-------RKAW-----EQQSDEYDIQLDVGFIE 455
            .:.|..|||.|.....:...:.::  |.||:|       .:.|     ::...|...|:|
Mouse   496 AQQALMGTINTSMHAVQQAQDDLS--ELDSLPPLGQDMASRVWVQNKVDESKHEIHSQVD----- 553

  Fly   456 QCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVK 520
                            |.::|..|.:.|  |..|.........|..:.||.....|..:
Mouse   554 ----------------AITAGTASVVNL--TAGDPADTDYTAVGCAITTISSNLTEMSK------ 594

  Fly   521 GGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELL 585
             ||.|...:.                   .|:|  .:|.|:  ||..:.:|       .|..:||
Mouse   595 -GVKLLAALM-------------------DDDV--GSGEDL--LRAARTLA-------GAVSDLL 628

  Fly   586 LTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLL-------DGDALFTQSLLLLSDGLASGALL 643
            ..|:|...       ||....:..:..||..|..|       :.|..|...|:.|:..:|:.|.:
Mouse   629 KAVQPTSG-------EPRQTVLTAAGSIGQASGDLLRQIGENETDERFQDVLMSLAKAVANAAAM 686

  Fly   644 AQYELMYRKN----PDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIP 704
            .   ::..||    .:..:.:.|..|.|.:..........|.:| :..:::........:.   .
Mouse   687 L---VLKAKNVAQVAEDTVLQNRVIAAATQCALSTSQLVACAKV-VSPTISSPVCQEQLIE---A 744

  Fly   705 GGAVNRYI-----ATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL 764
            |..|:|.:     |.|.  |::.::..:.|...:|.:...|..:::..||...:..|: |...|.
Mouse   745 GKLVDRSVENCVRACQA--ATSDSELLKQVSAAASVVSQALHDLLQHVRQFASRGEPI-GRYDQA 806

  Fly   765 AEGFSVRCLSE----KPDETGSFVFREFVL------------KDKHEQRHIHHMQYLAWPDHCVP 813
            .:  ::.|::|    ...:.|..|.:..||            .|...:..:.:.:.|.
Mouse   807 TD--TIMCVTESIFSSMGDAGEMVRQARVLAQATSDLVNAMRSDAEAEIDMENSKKLL------- 862

  Fly   814 SDPNLFLEFTER-VRAARNRTLLQEIEESLKQVR-----LMDADADADENG---GLMRERKCAAS 869
            :...|..:.|.| |.||:......|.|:..:::|     |..|...|.:|.   .::...:.||.
Mouse   863 AAAKLLADSTARMVEAAKGAAANPENEDQQQRLREAAEGLRVATNAAAQNAIKKKIVNRLEVAAK 927

  Fly   870 NGATPEDETPVSTSVHQCISAANP----PVIVHCSA 901
            ..|....:| ::.|.:..||..||    .::..|.|
Mouse   928 QAAAAATQT-IAASQNAAISNKNPSAQQQLVQSCKA 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	55/230 (24%)
		FERM_N	38..102	CDD:286467	18/87 (21%)
		FERM_M	125..232	CDD:278785	26/109 (24%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	12/98 (12%)
		FA	333..369	CDD:285894	10/43 (23%)
		PDZ_signaling	502..589	CDD:238492	16/86 (19%)
		Y_phosphatase	666..955	CDD:278528	49/270 (18%)
		PTPc	668..955	CDD:238006	48/268 (18%)
Tln2	XP_006511496.1	FERM_F0_TLN2	6..89	CDD:340692	3/13 (23%)
		FERM_F1_TLN2	90..201	CDD:340694	25/117 (21%)
		FERM_M	211..318	CDD:395297	28/112 (25%)
		FERM_C_Talin	314..405	CDD:269973	13/110 (12%)
		Talin_middle	496..657	CDD:401182	43/229 (19%)
		I_LWEQ	691..>767	CDD:418644	13/81 (16%)
		talin-RS	1047..>1176	CDD:213393
		talin-RS	1658..1829	CDD:213393
		VBS	1852..1976	CDD:312463
		ILWEQ	2339..2549	CDD:214607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910