Protein Alignment Ptpmeg and kalrnb

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: NP_001314918.1
• Gene: kalrnb / 678652
• ZFINID: ZDB-GENE-060421-7244
• Length: 2306
• Species: Danio rerio
• Alignment Length: 983
• Identity: 185/983 - (18%)
• Similarity: 312/983 - (31%)
• Gaps: 324/983 - (32%)

  Fly    78 LFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKR 142
            :|.||.   .:::.:.:.:.|.|..|.|     |.:...::..:.:...|.|:.|.....:..|.
Zfish   422 VFHQKS---EQFLSSMEGWVKSCGEVGL-----PTVTQELELAIHNHQNLYEQVTTAYTEVSQKG 478

  Fly   143 NILLGKL-----PCSSNTQCLLASYT--VQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGE 200
            ..||..|     |..|.:....|.|:  |:..|...:.:.||...|.|:.              :
Zfish   479 KTLLDVLQRPPPPADSGSLTAGADYSQAVRGVLEVVHEVVHQYRRLEGLL--------------Q 529

  Fly   201 LHKLHRGQLPADAEYNYLEHAKRLEL--YGIDLHRATD---SNGKELQLGVSAVGLLVFQ-HSLR 259
            .|||...|              ||:|  :..|:.:..|   ::|:......:.||..|.: .:|:
Zfish   530 HHKLRLHQ--------------RLQLCVFQQDVQQVLDWIENHGEAFLSKHTGVGKSVHRARALQ 580

  Fly   260 VNTFSWSKMVKVSFKRKDFFIQLRR--------EPSENY--------------------DTLLGF 296
            .....:.::.:.::...|..::...        :|.|.|                    ..||..
Zfish   581 KRHDDFQEVAQNTYTNADKLLEAAEQLAQTGECDPEEIYAAAHHLEVRVQEFVRRVEQRKLLLDI 645

  Fly   297 GMSSHKHAKALW-------KSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQ 354
            .:|.|.|.|.||       ||.||.                         ......:.||||
Zfish   646 SVSFHTHTKELWSWMEDLQKSLVEP-------------------------VVNSESVDAVQE--- 682

  Fly   355 RGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSR 419
               :.:.|.:..|..|......:     ..|..:.||. .:||.:.|                ..
Zfish   683 ---LIRQFQQQQSSTLDATLNVI-----KEGEELIQHL-RDSALACN----------------KL 722

  Fly   420 PHDNKVTS--------KEADSMPRKAWEQQSDEYDIQLDVGFIEQ----CTRRFESASPSPMPPA 472
            ||.:.|..        .||.:...:.:.::..:.||.|.:...||    .....::.....|..|
Zfish   723 PHASSVAHIEGVLQQLDEAQAHMEELFHERRIKLDIFLQLRIFEQYALEVMGELDAWKQDLMRQA 787

  Fly   473 YSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGR-----------YGFNVKGGVDLS 526
            .......     .|:|:...|:..|....:..:..:..:||:           .|..:.|..|:.
Zfish   788 TDFNTEE-----LTLAEQRLHRHTERKLAMNNMTYEVIQQGQDLHQYIMEVQASGMELTGEKDVD 847

  Fly   527 LPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVH-------GLRH-----EQVVAMIRDCRHQ 579
            |..:|.:::..         :.|....|.::....|       .|||     :||:..||
Zfish   848 LAAKVQELLEF---------LNEKQHELEVSAEHTHKRLEQCLQLRHLQAEVKQVLGWIR----- 898

  Fly   580 ASGELLLTVRPQRSAPL-----LLEEEPLYQYVPES----DEI-GSHSNLL-------------- 620
             :||.:||.....:.||     |..|...:|...||    |.: .:|.:.|
Zfish   899 -NGESMLTASTTNAGPLSEVEQLQREHEQFQLAIESLLHADSLQRTHQSALQLQQRAELLLQAGH 962

  Fly   621 -DGD---------ALFTQSLLL-LSDGL----ASGA----------LLAQYELMYRKNPD----- 655
             |.|         ||..|:|:| :.|.|    ||.|          :|...||.||:..|
Zfish   963 YDPDAVRACAETVALHWQTLMLKMEDRLKLVNASVAFYKTSEQVCNVLESLELEYRREEDWCGGH 1027

  Fly   656 -----LAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRYIATQ 715
                 .|.|:...|........::.....||.......:...||:.|.|:|.   |.|....||:
Zfish  1028 DKLGSTAETDHVSPLINKHLEQKEAFLKACTLARRNAEVFLKYIHRNNVSMP---GVVTHNRATE 1089

  Fly   716 GPLASTTTD----------FWRMVQQE----------SSHLLVMLTTVMESGRQ--KCHQYWPVT 758
            ..:.:..::          ||.|.::.          ..|....:..:.|:|..  ..|.....|
Zfish  1090 SQVKAILSELLQRENRVLHFWTMKKRRLDQCQQYVLFERHAKQAIDWLQETGEYFLSTHTSSGET 1154

  Fly   759 GEELQ--LAEGFSVRCLSEKPDE--------TGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVP 813
            .|:.|  |.|....|..:::..|        .||.|          |:.|:|..:...|    |.
Zfish  1155 SEKAQELLKEYEDFRVSAKQTQEKVKLLIQLAGSLV----------EKGHVHVTELKRW----VS 1205

  Fly   814 SDPNLFLEFTERV---RAARNRTL-----------LQEIEESL----KQVRLMDADADADENGGL 860
            :....:.:|:.|:   |.:.:|.|           |..|..:|    .:|.|.|.|.:.:|
Zfish  1206 TVDRRYRDFSMRMGHYRCSLDRALGVCSEDNKDLELDIIPANLTHTDPEVNLNDPDHEVNE---- 1266

  Fly   861 MRERKCAA 868
              |:|.:|
Zfish  1267 --EKKKSA 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	33/162 (20%)
		FERM_N	38..102	CDD:286467	5/23 (22%)
		FERM_M	125..232	CDD:278785	25/115 (22%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	24/134 (18%)
		FA	333..369	CDD:285894	6/35 (17%)
		PDZ_signaling	502..589	CDD:238492	21/109 (19%)
		Y_phosphatase	666..955	CDD:278528	49/253 (19%)
		PTPc	668..955	CDD:238006	49/251 (20%)
kalrnb	NP_001314918.1	SEC14	46..184	CDD:214706
		SPEC	197..413	CDD:238103
		SPEC	540..757	CDD:238103	42/269 (16%)
		SPEC	882..1120	CDD:238103	56/246 (23%)
		SPEC	1126..1214	CDD:197544	19/101 (19%)
		RhoGEF	1277..1446	CDD:238091
		PH1_Kalirin_Trio_like	1453..1575	CDD:270060
		PH	1486..1571	CDD:278594
		SH3_Kalirin_1	1641..1700	CDD:212786
		SH3-RhoG_link	1697..>1864	CDD:293215
		RhoGEF	1886..2056	CDD:279015
		PH2_Kalirin_Trio_p63RhoGEF	2060..2193	CDD:270061
		PH	2083..2178	CDD:278594
		SH3	2246..2302	CDD:302595

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910