DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptpmeg and SNTB1

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_066301.1 Gene:SNTB1 / 6641 HGNCID:11168 Length:538 Species:Homo sapiens


Alignment Length:660 Identity:136/660 - (20%)
Similarity:225/660 - (34%) Gaps:232/660 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   342 GRTELQAVQESKQRGRIHKVFVRSPSKRLL-----GAA--GGVGTS-------GSSGGTPMQQHS 392
            ||.:...:.|...|.|.|||.|......|:     |||  .|:||:       |:..|.|     
Human    18 GRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGIGTATNGSFCRGAGAGHP----- 77

  Fly   393 GSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQC 457
                          |||       .::|.|                                   
Human    78 --------------GAG-------GAQPPD----------------------------------- 86

  Fly   458 TRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGG 522
                   ||:.:..|::.       ||..:.:::.:|:.       .:::...|.|..|.::|||
Human    87 -------SPAGVRTAFTD-------LPEQVPESISNQKR-------GVKVLKQELGGLGISIKGG 130

  Fly   523 VDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLT 587
            .:..:|:.:||:.....||: |..:..||.:|.:||.|:....|::.|..::    :|..|:||.
Human   131 KENKMPILISKIFKGLAADQ-TQALYVGDAILSVNGADLRDATHDEAVQALK----RAGKEVLLE 190

  Fly   588 VRPQRSA-PLLLEEEPLYQY-----VPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQY 646
            |:..|.| |.:.:..|:.:.     .|||..:|..::    |...:||.....|           
Human   191 VKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTS----DPPSSQSFSFHRD----------- 240

  Fly   647 ELMYRKNPDLA---ITEARKPANAPKNRYRDISPYDCTRVSLVNS---------LTGDYINANYV 699
                ||:..|.   :|.:...|: |:||..:|...|.....::.|         .:..:.|.|.:
Human   241 ----RKSIPLKMCYVTRSMALAD-PENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDL 300

  Fly   700 NMEI----------PGGAVNRYIATQGPLA----STTTDFWR---MVQQESSHLL---------- 737
            ...:          .|.|.:|.|...|.||    ..:...|:   :|..|...|:          
Human   301 LTRVIAEVREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEA 365

  Fly   738 ---------VMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKD- 792
                     ::.|.::.||..|..   |..|.:|    .|:.|..:.:..||  .:||....:| 
Human   366 WFSPVHTYPLLATRLVHSGPGKGS---PQAGVDL----SFATRTGTRQGIET--HLFRAETSRDL 421

  Fly   793 KHEQRHI----HHMQYL--AWPDHCVPSD---------PNLFLEFTERVRAARNRTLLQEIEESL 842
            .|..|.|    |:...|  .....|...:         .|.|...||....|..:|::|...|.|
Human   422 SHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKL 486

  Fly   843 KQ-----VRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPV-IVH--C 899
            |.     :|::..|.     ||                .:..:...:|.|   ..|.| |:|  .
Human   487 KMSSDDGIRMLYLDF-----GG----------------KDGEIQLDLHSC---PKPIVFIIHSFL 527

  Fly   900 SAGIGRTGVL 909
            ||.|.|.|::
Human   528 SAKITRLGLV 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604
FERM_N 38..102 CDD:286467
FERM_M 125..232 CDD:278785
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010
FA 333..369 CDD:285894 9/26 (35%)
PDZ_signaling 502..589 CDD:238492 24/86 (28%)
Y_phosphatase 666..955 CDD:278528 64/313 (20%)
PTPc 668..955 CDD:238006 64/311 (21%)
SNTB1NP_066301.1 PDZ_signaling 111..192 CDD:238492 24/92 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 205..237 8/35 (23%)
PH <231..295 CDD:278594 14/79 (18%)
PHsplit_syntrophin <242..299 CDD:269960 11/57 (19%)
PH 323..433 CDD:278594 25/118 (21%)
PH 323..433 CDD:214574 25/118 (21%)
Calmodulin-binding. /evidence=ECO:0000250 518..538 9/20 (45%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.