DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Pdzd2

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038959013.1	Gene:	Pdzd2 / 65034	RGDID:	619958	Length:	2818	Species:	Rattus norvegicus

Alignment Length:	793	Identity:	154/793 - (19%)
Similarity:	243/793 - (30%)	Gaps:	300/793 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 KFYYSGRTELQAVQ--ESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSG-GTPMQQHS-----G 393
            :|..:|:|:.|:..  ..::.|||.|:       .||..:.|:|...|.| |:....|:     .
  Rat   309 RFSKTGKTDFQSSDCLAREEVGRIWKM-------ELLKESDGLGIQVSGGRGSKRSPHAIVVTQV 366

  Fly   394 SESANSHNNGK-----------------------------PAGAGTILTITKTSRPHD-NKVTSK 428
            .|...:|.:|:                             ..|...::..:|.|...| .|:|||
  Rat   367 KEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKESSAEDLLKLTSK 431

  Fly   429 EADSMP--------RKAWEQQSDE---------------------YDIQLDVGFIEQCTRRFESA 464
               |:|        ..:|....|:                     .:...|||..|:.....||.
  Rat   432 ---SLPDLTSSVEDMSSWTDNEDQEAAGEDEEGSGPAAVRVTMPGSEESQDVGSSEESKGNLESP 493

  Fly   465 S----PSPMPPAYSSGQHS---------------------------------PILLPTTIADAVG 492
            .    .:.:....|.|.|.                                 |.||.:|......
  Rat   494 KQGNCKTKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSTGTSQEY 558

  Fly   493 HQQPESGSDLITIRLQA----------------DEQGR-YGFNVKGGVDL---SLPVQVSKVVPH 537
            |...:|...|.|..:::                .|:|: .||::.||.|.   .:.:.|..:.|:
  Rat   559 HIVKKSTRSLSTTHVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPN 623

  Fly   538 TPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLE-EE 601
            ..|.. ..|:.||||:|.:||..:.||..::.:...:..|   ||..:||||.:..:|.|.. ..
  Rat   624 GSAAE-DGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIR---SGLFVLTVRTKLLSPSLTPCST 684

  Fly   602 PLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYE----LMYRKNPD------L 656
            |.:.....|....::|.                 |..:|.  .|.|    .:.||.|.      :
  Rat   685 PTHMSRSSSPSFNTNSG-----------------GTPAGG--GQEEGGSSSLGRKAPGPKDRIVM 730

  Fly   657 AITEARKP-------------ANAPKNRY-RDISPYDCTRVSLVNSLTGDYI-NANYVNM----- 701
            .:|..::|             .|:|...| ..::|....::. .|...||.| ..|.||:
  Rat   731 EVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKME-SNLSRGDQILEVNSVNVRHAAL 794

  Fly   702 --------EIPGGAVNRYIATQ-GPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPV 757
                    :.|.|.|...|... .|..|         :||...::.. :|..||......   |.
  Rat   795 SKVHAILSKCPPGPVRLVIGRHPNPKVS---------EQEMDEVIAR-STYQESREANSS---PG 846

  Fly   758 TGEELQ---LAEGFSVRCLSEKP-------DETGSFVFREFVLKDKHEQRH-------------- 798
            .|..|:   ||:..|:  |||..       |..||  ..:||:....::.|
  Rat   847 LGTPLKSPSLAKKDSL--LSESELSQYFVHDGQGS--LSDFVVAGSEDEDHPGSGYETSEDGSLL 907

  Fly   799 -----------------------IHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEE 840
                                   :.|.|........:|..|.:.          ||..|.|
  Rat   908 PVPSAHKARANSLVTLGSQRTSGLLHKQVTVARQASLPGSPQVL----------RNPLLRQ---- 958

  Fly   841 SLKQVRLMDADA---DADENGGLMRERKCAASNGATP-------EDET-PVSTSVHQCISA---- 890
              ::||..|::.   |.|.:|    |..|.:..|..|       ||:| |..|:..:.|..
  Rat   959 --RRVRCYDSNGGSDDEDFDG----EGDCISLPGVLPGPGKPLVEDDTRPALTTSSKSIDVNKQE 1017

  Fly   891 ---ANPPVIVHCS 900
               ..|.|...||
  Rat  1018 ERLQKPLVSKACS 1030

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894	8/33 (24%)
		PDZ_signaling	502..589	CDD:238492	27/106 (25%)
		Y_phosphatase	666..955	CDD:278528	65/316 (21%)
		PTPc	668..955	CDD:238006	64/314 (20%)
Pdzd2	XP_038959013.1	PDZ_signaling	335..416	CDD:238492	12/87 (14%)
		PDZ_signaling	590..671	CDD:238492	25/84 (30%)
		PDZ_signaling	729..813	CDD:238492	16/84 (19%)
		PHA03247	<985..1446	CDD:223021	12/46 (26%)
		PDZ_signaling	2603..2677	CDD:238492
		PDZ_signaling	2731..2813	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910