Protein Alignment Ptpmeg and Epb41l1

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: NP_067713.2
• Gene: Epb41l1 / 59317
• RGDID: 71087
• Length: 1551
• Species: Rattus norvegicus
• Alignment Length: 1081
• Identity: 280/1081 - (25%)
• Similarity: 421/1081 - (38%)
• Gaps: 324/1081 - (29%)

  Fly    24 ARDKKTPQ------RQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLF--- 79
            ::.:|:||      :.....|..||...:...:||..:|..|.|.|.::|.|.|:|||||.|
  Rat    81 SKAQKSPQKIAKKFKSATCRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLLEKDYFGLTFCDA 145

  Fly    80 -PQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRN 143
             .||     .|:|..|:.|||..|...:      ..|.|||:..||::|.|:.|||...||::.:
  Rat   146 DSQK-----NWLDPSKEIKKQIRSSPWN------FAFTVKFYPPDPAQLTEDITRYYLCLQLRAD 199

  Fly   144 ILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQ 208
            |:.|:||||..|..||.||.||:||||.:..||...|:|.::...:||.|.|.::.||||.:||.
  Rat   200 IITGRLPCSFVTHALLGSYAVQAELGDHDTEEHVGNYVSELRFAPNQTRELEERIMELHKTYRGM 264

  Fly   209 LPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSF 273
            .|.:||.::||:||:|.:||:|||.|.||.|.::.|||.|.|||:::..||:|.|:|.|::|:|:
  Rat   265 TPGEAEIHFLENAKKLSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISY 329

  Fly   274 KRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSR-FLNISLGSK 337
            ||.:|:|::|....|.:::.:||.:.:|:.||.|||.|:|||:||||..|....: ||  .:|||
  Rat   330 KRSNFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFL--VMGSK 392

  Fly   338 FYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSG-------SE 395
            |.|||||:.|..|.|....|....|.||.|||...:....|...|...:..:.|..       .:
  Rat   393 FRYSGRTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDGAEFSRPASVSENHDAGPDGDKRED 457

  Fly   396 SANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDI----QLDVGFIEQ 456
            .|.|......|..|.:.|.||.      |....|.::.||...|......|:    |..:..:::
  Rat   458 DAESGGRRSEAEEGEVRTPTKI------KELKPEQETTPRHKQEFLDKPEDVLLKHQASINELKR 516

  Fly   457 C-----------------TRRFES--ASPSP--MPPAYSSGQH-----SPILLPTT--------- 486
            .                 .||..|  |||||  .|...|..|.     ...|:|.|
  Rat   517 TLKEPNSKLIHRDRDWERERRLPSSPASPSPKGTPEKASEAQRIQDTSRQDLVPGTATGLEMFTQ 581

  Fly   487 ---------------------------IADAVGHQQPESGSDLI--------------------- 503
                                       :......|:.||||.|.
  Rat   582 KSLAASPEGSEHWVFIERVYTRPEDLGLLTVAATQRKESGSSLSGILADGRLSKVDILVDKFKVE 646

  Fly   504 --------TIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADR-------CTPRVCEGDEV 553
                    |.|....:||:.         |:.|.....|   ...||       .|.::.||..:
  Rat   647 VATEETVRTRRTSTQQQGKM---------LASPEDFETV---REEDRGGPGEATSTDKLPEGSRL 699

  Fly   554 LMINGRDVHGLRHEQVVAMIRDC--RHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSH 616
            .:.|    ||:.:.|:.:.:...  |.|..|      ||..:....::.|.|   .|.||:.|..
  Rat   700 KLRN----HGVSNGQLESQVEWGLERPQTWG------RPTAAGLGPVQGEVL---SPTSDKGGLQ 751

  Fly   617 SNLLD-------------GDALFTQSLLLLSDGL--ASGALLAQYELMYRKNPDLAITEARKPAN 666
            |.|||             .|..|.:....|..|.  :...|||                   |.:
  Rat   752 SFLLDPAQAEARADSSDETDTSFAERSFCLHYGEKDSEDQLLA-------------------PPS 797

  Fly   667 APKNRYRDISPYDCTRVSLVNSLTGDY-INANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQ 730
            ..:..:.|..|.|.|.:.|....|.:: :.::......||.:.::..|.:.|.|.   :.|
  Rat   798 EHREEHPDALPGDGTWLELAGVHTENWELKSSDPRASAPGSSQHKDQAHKAPSAE---EAW---- 855

  Fly   731 QESSHLLVMLTTVMESGR----------QKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVF 785
                       |..:.||          |...:.|..|.:.|   ||..|:.|:.
  Rat   856 -----------TPRDHGRPDDPQGAAVGQTFEEVWENTQQRL---EGELVQPLAS---------- 896

  Fly   786 REFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNR-----------------T 833
               |.:|:                  ||::.: ::..||:...||.:                 .
  Rat   897 ---VAEDE------------------VPTNMD-WMGKTEKSPPARRKKSPPGRGGGVHLDAQACA 939

  Fly   834 LLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDE-------TPVSTSVHQCISAA 891
            ||:.|...:::      .|..|:...|.:|:...:.....||.|       .|||:
  Rat   940 LLRTIPPCVRK------PARPDQGSFLPKEKGTVSPPAVEPETEDRETVSPLPVSS--------- 989

  Fly   892 NPPVIVHCSAGIGRTGVLILMD-TALALM--------EARE 923
                        |.|.||..|: |:|:.:        |:||
  Rat   990 ------------GHTEVLAAMEGTSLSPLPPGSRGPSESRE 1018

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	82/200 (41%)
		FERM_N	38..102	CDD:286467	26/67 (39%)
		FERM_M	125..232	CDD:278785	49/106 (46%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	44/93 (47%)
		FA	333..369	CDD:285894	17/35 (49%)
		PDZ_signaling	502..589	CDD:238492	20/124 (16%)
		Y_phosphatase	666..955	CDD:278528	54/302 (18%)
		PTPc	668..955	CDD:238006	54/300 (18%)
Epb41l1	NP_067713.2	B41	98..288	CDD:214604	82/200 (41%)
		FERM_C_4_1_family	283..376	CDD:270005	44/92 (48%)
		FA	385..428	CDD:400882	21/44 (48%)
		SAB	493..>524	CDD:398195	3/30 (10%)
		4_1_CTD	1414..1538	CDD:399118

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910