DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and MPP4

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_149055.2	Gene:	MPP4 / 58538	HGNCID:	13680	Length:	637	Species:	Homo sapiens

Alignment Length:	208	Identity:	46/208 - (22%)
Similarity:	93/208 - (44%)	Gaps:	31/208 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   480 PILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCT 544
            |:|.|  :.|.:    |||...:..:.|..::| ..|..:|.. :::..:.|::::....|:| :
Human   136 PLLPP--LPDNI----PESEEAMRIVCLVKNQQ-PLGATIKRH-EMTGDILVARIIHGGLAER-S 191

  Fly   545 PRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPL----LLEEEPLYQ 605
            ..:..||:::.:||..|.||..|||:.::...|    |.::..|.|....|:    ::....:.:
Human   192 GLLYAGDKLVEVNGVSVEGLDPEQVIHILAMSR----GTIMFKVVPVSDPPVNSQQMVYVRAMTE 252

  Fly   606 YVPESD------------EIGSHSNLLD-GDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLA 657
            |.|:.|            :.|....::| .|||:.|: ..:||......|:....|:.||..:..
Human   253 YWPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQA-RKISDPATCAGLVPSNHLLKRKQREFW 316

  Fly   658 ITEARKPANAPKN 670
            .::..:|....|:
Human   317 WSQPYQPHTCLKS 329

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	19/86 (22%)
		Y_phosphatase	666..955	CDD:278528	1/5 (20%)
		PTPc	668..955	CDD:238006	1/3 (33%)
MPP4	NP_149055.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		L27	30..83	CDD:197794
		L27	90..140	CDD:197794	2/3 (67%)
		PDZ_signaling	153..232	CDD:238492	19/85 (22%)
		SH3_MPP4	246..306	CDD:212967	12/60 (20%)
		Guanylate_kin	428..618	CDD:331880
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910