DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpmeg and PTPRM

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:XP_011524010.1 Gene:PTPRM / 5797 HGNCID:9675 Length:1507 Species:Homo sapiens


Alignment Length:747 Identity:158/747 - (21%)
Similarity:253/747 - (33%) Gaps:276/747 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   286 PSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYY------SGRT 344
            |:::......|.:..:|.....|.:.:..:..:|:                  |:      :|.|
Human   666 PADSLQAAQPFTIGDNKTYNGYWNTPLLPYKSYRI------------------YFQAASRANGET 712

  Fly   345 ELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHN---NGKPA 406
            ::..||.: .:..|....:.:|..|:..|||....:|::...|:.:   .|....|.   .|..|
Human   713 KIDCVQVA-TKAAIIVTQLTTPYIRIAPAAGDGQLTGAATPKPVPE---PEKQTDHTVKIAGVIA 773

  Fly   407 G--------AGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFES 463
            |        .|.:|.:.|      .|:..|..::|  .:..|:.......:|..:.||.|...|:
Human   774 GILLFVIIFLGVVLVMKK------RKLAKKRKETM--SSTRQEMTVMVNSMDKSYAEQGTNCDEA 830

  Fly   464 --------------ASPS-----------PMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLI 503
                          :|||           .:|.:|    :....:||.|...:..:.....||..
Human   831 FSFMDTHNLNGRSVSSPSSFTMKTNTLSTSVPNSY----YPDPFVPTAILVPINDETHTMASDTS 891

  Fly   504 TI--------RLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRD 560
            ::        |..||...:.|       .|...::|:.::.|....:|    .||          
Human   892 SLVQSHTYKKREPADVPYQTG-------QLHPAIRVADLLQHITQMKC----AEG---------- 935

  Fly   561 VHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSNLLDGDAL 625
             :|.:.|                                                :.:..:|.: 
Human   936 -YGFKEE------------------------------------------------YESFFEGQS- 950

  Fly   626 FTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSL----- 685
                              |.::            .|:|..|..||||.:|..||.:||.|     
Human   951 ------------------APWD------------SAKKDENRMKNRYGNIIAYDHSRVRLQTIEG 985

  Fly   686 -VNSLTGDYINANYVN-MEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGR 748
             .||   ||||.||:: ...|    |.|||||||:..|..||||||..|::..::|:|.::|.||
Human   986 DTNS---DYINGNYIDGYHRP----NHYIATQGPMQETIYDFWRMVWHENTASIIMVTNLVEVGR 1043

  Fly   749 QKCHQYWP----------VTGEELQLAEGFSVRCLSEKPDETGSFV----FREFVLKDKHEQRHI 799
            .||.:|||          ||..|.:|...:.:|..:.:....|...    .||...:..||.|.|
Human  1044 VKCCKYWPDDTEIYKDIKVTLIETELLAEYVIRTFAVEKGGAGGEANCSPSREVSQRGVHEIREI 1108

  Fly   800 HHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRER 864
            ....:..||||.||......|.|..:|::                                    
Human  1109 RQFHFTGWPDHGVPYHATGLLGFVRQVKS------------------------------------ 1137

  Fly   865 KCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLD 929
                        ::|.|..          |::||||||.||||..|::|..|.:.|....|...:
Human  1138 ------------KSPPSAG----------PLVVHCSAGAGRTGCFIVIDIMLDMAEREGVVDIYN 1180

  Fly   930 IVRTMRDQRACMVQNVSQYRFVCE-----CIC 956
            .||.:|.:|..|||...||.|:.:     |:|
Human  1181 CVRELRSRRVNMVQTEEQYVFIHDAILEACLC 1212

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604
FERM_N 38..102 CDD:286467
FERM_M 125..232 CDD:278785
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 4/33 (12%)
FA 333..369 CDD:285894 7/41 (17%)
PDZ_signaling 502..589 CDD:238492 12/94 (13%)
Y_phosphatase 666..955 CDD:278528 95/314 (30%)
PTPc 668..955 CDD:238006 94/312 (30%)
PTPRMXP_011524010.1 MAM 22..182 CDD:214533
MAM 27..182 CDD:99706
IG_like 192..278 CDD:214653
ig 192..274 CDD:278476
FN3 282..361 CDD:214495
FN3 383..477 CDD:238020
FN3 499..581 CDD:238020
PTPc 937..1208 CDD:214550 101/414 (24%)
PTPc 964..1208 CDD:238006 94/308 (31%)
PTPc 1240..1502 CDD:214550
PTPc 1270..1502 CDD:238006
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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