DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptpmeg and PTPRK

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_001278910.1 Gene:PTPRK / 5796 HGNCID:9674 Length:1462 Species:Homo sapiens


Alignment Length:776 Identity:178/776 - (22%)
Similarity:273/776 - (35%) Gaps:245/776 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   307 LWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLL 371
            ||.|  .||.|..|                                 ..|..::.|:|:.:.:..
Human   550 LWNS--THHVFMHL---------------------------------HPGTTYQFFIRASTVKGF 579

  Fly   372 GAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRK 436
            |.|..:..:.:.....:..:.|.:::.:.         |..|||...||       .:|...|..
Human   580 GPATAINVTTNISAPTLPDYEGVDASLNE---------TATTITVLLRP-------AQAKGAPIS 628

  Fly   437 AWE---QQSDEYDIQLDVGFIE--QCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQ- 495
            |::   ::...:..:.:.|.:|  |....:::|. |...|.|.:.:..|..||......||..: 
Human   629 AYQIVVEELHPHRTKREAGAMECYQVPVTYQNAM-SGGAPYYFAAELPPGNLPEPAPFTVGDNRT 692

  Fly   496 ----------PESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVC-- 548
                      |..|.::.             |.....|:.....|..::.....|.. .|.|.  
Human   693 YQGFWNPPLAPRKGYNIY-------------FQAMSSVEKETKTQCVRIATKAAATE-EPEVIPD 743

  Fly   549 ---EGDEVLMING----------------------------RDVHGLRHEQ----VVAMIRDCRH 578
               :.|.|:.|.|                            :|..|...::    |.||.|....
Human   744 PAKQTDRVVKIAGISAGILVFILLLLVVILIVKKSKLAKKRKDAMGNTRQEMTHMVNAMDRSYAD 808

  Fly   579 Q----ASGELLLTVRPQRSAPLLLEEEPLYQ---YVPESDE----IGSHSNLLD----------- 621
            |    |...|.:|...|.:....|..:||..   .||.:||    ....|.|||           
Human   809 QSTLHAEDPLSITFMDQHNFSPRLPNDPLVPTAVLVPITDENHSATAESSRLLDVPRYLCEGTES 873

  Fly   622 -------------GDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYR 673
                         .|.|...:|:..||   |.....:||..: :....:...|:|..|..||||.
Human   874 PYQTGQLHPAIRVADLLQHINLMKTSD---SYGFKEEYESFF-EGQSASWDVAKKDQNRAKNRYG 934

  Fly   674 DISPYDCTRVSL---VNSLTGDYINANYVNMEIPGGAVNR---YIATQGPLASTTTDFWRMVQQE 732
            :|..||.:||.|   .:..:.|||||||:::.:......|   |||||||:..|..|||||:.||
Human   935 NIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQE 999

  Fly   733 SSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDK--HE 795
            .|..:||:|.::|.||.||::|||   ::.::...|.|.|:..:|  ...:|.|.|.|:.:  :|
Human  1000 QSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEMEP--LAEYVVRTFTLERRGYNE 1059

  Fly   796 QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGL 860
            .|.:....:..||||.||......|.|..||:.:                               
Human  1060 IREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLS------------------------------- 1093

  Fly   861 MRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPV 925
                             .|.|..          |::||||||.||||..|::|..|.:.|....|
Human  1094 -----------------NPPSAG----------PIVVHCSAGAGRTGCYIVIDIMLDMAEREGVV 1131

  Fly   926 YPLDIVRTMRDQRACMVQNVSQYRFVCE-----CIC-----------AAYMKISRSSAAIN 970
            ...:.|:.:|.:|..|||...||.|:.:     |:|           |||..:.|..:..|
Human  1132 DIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTN 1192

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604
FERM_N 38..102 CDD:286467
FERM_M 125..232 CDD:278785
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 6/12 (50%)
FA 333..369 CDD:285894 3/35 (9%)
PDZ_signaling 502..589 CDD:238492 20/127 (16%)
Y_phosphatase 666..955 CDD:278528 93/301 (31%)
PTPc 668..955 CDD:238006 92/299 (31%)
PTPRKNP_001278910.1 MAM 32..192 CDD:214533
IG_like 202..288 CDD:214653
fn3 297..371 CDD:365830
fn3 488..581 CDD:365830 10/65 (15%)
PTP_DSP_cys 888..1166 CDD:391942 103/344 (30%)
Substrate binding. /evidence=ECO:0000250 1105..1111 4/5 (80%)
R-PTPc-K-2 1252..1457 CDD:350484
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.