DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and PTPRG

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_016862450.1	Gene:	PTPRG / 5793	HGNCID:	9671	Length:	1485	Species:	Homo sapiens

Alignment Length:	723	Identity:	172/723 - (23%)
Similarity:	255/723 - (35%)	Gaps:	252/723 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 AVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTIL 412
            |...|||..|        |......|....|..|.|  :|.:...|:|....
Human   581 AASASKQAAR--------PVLATTEALASPGPDGDS--SPTKDGEGTEEGEK------------- 622

  Fly   413 TITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPA---YS 474
                     |.|..|::.:....:..|:.|::.:   ..|.......| ....|||.|.:   .:
Human   623 ---------DEKSESEDGEREHEEDGEKDSEKKE---KSGVTHAAEER-NQTEPSPTPSSPNRTA 674

  Fly   475 SGQHSPI--------LLPTTIADAVGHQQ---PESGSDLIT---IRLQADEQGRYGFNVKGGVDL 525
            .|.|..|        .:||   |..|.::   |....|::|   :...|.|: :|     .|.|.
Human   675 EGGHQTIPGHEQDHTAVPT---DQTGGRRDAGPGLDPDMVTSTQVPPTATEE-QY-----AGSDP 730

  Fly   526 SLPVQVSKVVPHTPADRCTPRVCEGDEVLMIN--GRDVHGL-------RHEQVVAMI-------- 573
            ..|...|| .|.:..||.:    |....:.:|  .::..|:       |.|.::.:|
Human   731 KRPEMPSK-KPMSRGDRFS----EDSRFITVNPAEKNTSGMISRPAPGRMEWIIPLIVVSALTFV 790

  Fly   574 ------------RDCRH-------------QASGE--------LLLT------------VRPQRS 593
                        |.|..             .:|||        ...|            |.|..|
Human   791 CLILLIAVLVYWRGCNKIKSKGFPRRFREVPSSGERGEKGSRKCFQTAHFYVEDSSSPRVVPNES 855

  Fly   594 APLL-----LEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKN 653
            .|::     :|..|:.|:|....|:  :||...|   |::                .:|.:.|..
Human   856 IPIIPIPDDMEAIPVKQFVKHIGEL--YSNNQHG---FSE----------------DFEEVQRCT 899

  Fly   654 PDLAIT--EARKPANAPKNRYRDISPYDCTRVSL-----VNSLTGDYINANYVNMEIPGGAVNR- 710
            .|:.||  .:..|.|..||||.:|..||.:||.|     .:|...||||||||:      ..|:
Human   900 ADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVD------GYNKA 958

  Fly   711 --YIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEE------------ 761
              ||||||||.||..|||||:.::::.::||:|.::|.||:||.||||....|
Human   959 KAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKST 1023

  Fly   762 ----LQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEF 822
                ......||:|....|..:.|:       .|.:..:|.:....|..|||..||......|.|
Human  1024 KIHACYTVRRFSIRNTKVKKGQKGN-------PKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF 1081

  Fly   823 TERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQC 887
            ..|..|||                                          .||
Human  1082 VRRSSAAR------------------------------------------MPE------------ 1092

  Fly   888 ISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVC 952
                ..||:||||||:||||..|::|:.|..::.:..|..|..::.:|.||..:||...||.|:.
Human  1093 ----TGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIH 1153

  Fly   953 ECICAAYM 960
            :.:..|.:
Human  1154 DALLEAIL 1161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894	6/20 (30%)
		PDZ_signaling	502..589	CDD:238492	24/151 (16%)
		Y_phosphatase	666..955	CDD:278528	95/312 (30%)
		PTPc	668..955	CDD:238006	94/310 (30%)
PTPRG	XP_016862450.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910