DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and PTPN14

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_005392.2	Gene:	PTPN14 / 5784	HGNCID:	9647	Length:	1187	Species:	Homo sapiens

Alignment Length:	1270	Identity:	283/1270 - (22%)
Similarity:	446/1270 - (35%)	Gaps:	452/1270 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VLFLDD--ITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQC 100
            :..||.  |..|..:|  :.|.|.|:.|.|.|||.|..||||.|..| ....|||:.:|..||.
Human    25 IRLLDSNVIECTLSVE--STGQECLEAVAQRLELRETHYFGLWFLSK-SQQARWVELEKPLKKH- 85

  Fly   101 SSVSLDNDA-VPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTV 164
                ||..| .|||.|.|.|:|.:.|.||:|.||||:|||:|:::|.|:|.|:.:....||...|
Human    86 ----LDKFANEPLLFFGVMFYVPNVSWLQQEATRYQYYLQVKKDVLEGRLRCTLDQVIRLAGLAV 146

  Fly   165 QSELGDFNALEHQ----PGYLSGMQLLCDQTT--EAERKVGELHKLHRGQLPADAEYNYLEHAKR 223
            |::.||:|..:.|    ...|..|.|..::..  |..:||.:.||.|.|.|||:||..|:...:|
Human   147 QADFGDYNQFDSQDFLREYVLFPMDLALEEAVLEELTQKVAQEHKAHSGILPAEAELMYINEVER 211

  Fly   224 LELYGIDLHRATDSNGKELQLGVSAVGLLVFQH-SLRVNTFSWSKMVKVSFKRKDFFIQLRREPS 287
            |:.:|.::....|::|..:.||:..:|:.|... ..:...:.|:.|..::..:....::|..:.
Human   212 LDGFGQEIFPVKDNHGNCVHLGIFFMGIFVRNRIGRQAVIYRWNDMGNITHNKSTILVELINKE- 275

  Fly   288 ENYDTLLGFGMSSHKHAKALWKSCVEHHSFFR--------------LKRPHRLSRF--------- 329
               :|.| |.....::||.:.:.....|.|::              ::|....||.
Human   276 ---ETAL-FHTDDIENAKYISRLFATRHKFYKQNKICTEQSNSPPPIRRQPTWSRSSLPRQQPYI 336

  Fly   330 ---LNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGS--------- 382
               :::..|.  :||   |....|:|...|....::..|.:...|....|..|:||
Human   337 LPPVHVQCGE--HYS---ETHTSQDSIFHGNEEALYCNSHNSLDLNYLNGTVTNGSVCSVHSVNS 396

  Fly   383 --------------------------SGGTPMQQHSG---------------------------- 393
                                      :...|..:||.
Human   397 LNCSQSFIQASPVSSNLSIPGSDIMRADYIPSHRHSAIIVPSYRPTPDYETVMRQMKRGILHTDS 461

  Fly   394 ----------------------------------------------------SESANSHNN---G 403
                                                                |:..|..||   .
Human   462 QSQSLRNLNIINTHAYNQPEDLVYSQPEMRERHPYTVPYGPQGVYSNKLVSPSDQRNPKNNVVPS 526

  Fly   404 KPAGAGTILTIT-------------------------------------KTSRP----HDNK-VT 426
            ||..:....|::                                     .||.|    |.:| |:
Human   527 KPGASAISHTVSTPELANMQLQGSHNYSTAHMLKNYLFRPPPPYPRPRPATSTPDLASHRHKYVS 591

  Fly   427 SKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASP------------------------- 466
            ....|.:.||          :||.|...:      |.:||
Human   592 GSSPDLVTRK----------VQLSVKTFQ------EDSSPVVHQSLQEVSEPLTATKHHGTVNKR 640

  Fly   467 ----------------------SPM----------PPAYSSGQHSPILLP-----TTIADAV--- 491
                                  .||          ||...||.|....||     .|.:||.
Human   641 HSLEVMNSMVRGMEAMTLKSLHLPMARRNTLREQGPPEEGSGSHEVPQLPQYHHKKTFSDATMLI 705

  Fly   492 --------GHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVC 548
                    ..:.|||...:..:|    |:..|...::..:         ..:|:.|     |...
Human   706 HSSESEEEEEEAPESVPQIPMLR----EKMEYSAQLQAAL---------ARIPNKP-----PPEY 752

  Fly   549 EGDEVLMINGRDVHGLRHEQ-----VVAMIRDCRHQASGELLL-----------TVRPQRSAPLL 597
            .|....:.||    .||.:|     .:|..|..||..:..:.:           ::.|..|.|.|
Human   753 PGPRKSVSNG----ALRQDQASLPPAMARARVLRHGPAKAISMSRTDPPAVNGASLGPSISEPDL 813

  Fly   598 -----------LEEEPLYQYVPESDEI-------------------------------------- 613
                       ::|.|:.:.....|.|
Human   814 TSVKERVKKEPVKERPVSEMFSLEDSIIEREMMIRNLEKQKMAGLEAQKRPLMLAALNGLSVARV 878

  Fly   614 -GSHSNLLDGDAL-FTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDIS 676
             |...|.:|...: ..:....|...|..|.:..:||.:.:|..:...:.|..|.||.::|.|::.
Human   879 SGREENRVDATRVPMDERFRTLKKKLEEGMVFTEYEQIPKKKANGIFSTAALPENAERSRIREVV 943

  Fly   677 PYDCTRVSLV---NSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLV 738
            ||:..||.|:   .:.|| ||||:::.: :.|||...||||||||..|..|||:||.::..:::.
Human   944 PYEENRVELIPTKENNTG-YINASHIKV-VVGGAEWHYIATQGPLPHTCHDFWQMVWEQGVNVIA 1006

  Fly   739 MLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKH----EQRHI 799
            |:|...|.||.|.|:|||..|.:...|.....:..::  ..|.|..:....||.||    ::|.:
Human  1007 MVTAEEEGGRTKSHRYWPKLGSKHSSATYGKFKVTTK--FRTDSVCYATTGLKVKHLLSGQERTV 1069

  Fly   800 HHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRER 864
            .|:||..||||..|.|...||.:.|.:::.|..|
Human  1070 WHLQYTDWPDHGCPEDVQGFLSYLEEIQSVRRHT------------------------------- 1103

  Fly   865 KCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLD 929
                             .|:.:.....:||::||||||:||||||||.:..:..:|..|.|....
Human  1104 -----------------NSMLEGTKNRHPPIVVHCSAGVGRTGVLILSELMIYCLEHNEKVEVPM 1151

  Fly   930 IVRTMRDQRACMVQNVSQYRFVCECICAAYMKISR 964
            ::|.:|:||..|:|.::||:||.: :...:::.||
Human  1152 MLRLLREQRMFMIQTIAQYKFVYQ-VLIQFLQNSR 1185

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	79/202 (39%)
		FERM_N	38..102	CDD:286467	26/65 (40%)
		FERM_M	125..232	CDD:278785	43/112 (38%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	17/108 (16%)
		FA	333..369	CDD:285894	8/35 (23%)
		PDZ_signaling	502..589	CDD:238492	16/102 (16%)
		Y_phosphatase	666..955	CDD:278528	95/295 (32%)
		PTPc	668..955	CDD:238006	93/293 (32%)
PTPN14	NP_005392.2	B41	24..220	CDD:214604	79/202 (39%)
		FERM_C_PTPN14_PTPN21	215..305	CDD:270009	17/94 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..531		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	671..690		5/18 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	787..824		4/36 (11%)
		PTPc	935..1179	CDD:238006	93/296 (31%)
		Substrate binding. /evidence=ECO:0000250	1121..1127		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810