Protein Alignment Ptpmeg and PTPN13

DIOPT Version :9

• Sequence 1: NP_001163309.2
• Gene: Ptpmeg / 38059
• FlyBaseID: FBgn0261985
• Length: 974
• Species: Drosophila melanogaster
• Sequence 2: XP_011530467.1
• Gene: PTPN13 / 5783
• HGNCID: 9646
• Length: 2507
• Species: Homo sapiens
• Alignment Length: 1007
• Identity: 217/1007 - (21%)
• Similarity: 358/1007 - (35%)
• Gaps: 317/1007 - (31%)

  Fly    57 SELLDQVFQYLEL--SERDYFGLLF--PQK---------------PGDVVRWVDAQKQFKKQCSS 102
            |.::.|...:.|.  |:.|....:|  |||               |.|:......|.| .:..||
Human  1689 SNMVSQAQSHHEAPKSQEDTICTMFYYPQKIPNKPEFEDSNPSPLPPDMAPGQSYQPQ-SESASS 1752

  Fly   103 VSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQ---------FYLQIKRNILLGKLPCSSNTQCL 158
            .|:|...:        ..:|:|:| ||.:|..:         |.|:::..|.|
Human  1753 SSMDKYHI--------HHISEPTR-QENWTPLKNDLENHLEDFELEVELLITL------------ 1796

  Fly   159 LASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVG-ELHKLHRGQLPADAEYNYLEHAK 222
                 ::||.|..       |:         ..|:..:::| .:|.:.  |.||.::.......:
Human  1797 -----IKSEKGSL-------GF---------TVTKGNQRIGCYVHDVI--QDPAKSDGRLKPGDR 1838

  Fly   223 RLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPS 287
            .:::...|:...|.::...|....|....||....|.:     .::..:.....|..:...:|.
Human  1839 LIKVNDTDVTNMTHTDAVNLLRAASKTVRLVIGRVLEL-----PRIPMLPHLLPDITLTCNKEE- 1897

  Fly   288 ENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLK-----RP------------------------ 323
                  |||.:            |..|.|.:::.     .|
Human  1898 ------LGFSL------------CGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVST 1944

  Fly   324 -----HRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSS 383
                 ..::|.|::||.|....:.|.:|..|..||:..      |.:|.......:..||:....
Human  1945 QGMTLEEVNRALDMSLPSLVLKATRNDLPVVPSSKRSA------VSAPKSTKGNGSYSVGSCSQP 2003

  Fly   384 GGTPMQQHS--GSESAN--SHNNGKPA-----GAGTILTITKTSRPHDNKVTSKEADSMPRKAWE 439
            ..||....|  ..|..|  |:..||.:     |:.. ||:.|.|.|:.:...||..::  .:::.
Human  2004 ALTPNDSFSTVAGEEINEISYPKGKCSTYQIKGSPN-LTLPKGSFPNQSSNYSKCPNN--SESYI 2065

  Fly   440 QQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLIT 504
            |:.|.||...:...|:                              ::.|.|    .|...:|:
Human  2066 QEDDIYDDSQEAEVIQ------------------------------SLLDVV----DEEAQNLL- 2095

  Fly   505 IRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGD-------EVLMINGRDVH 562
                 :|....|::...|. |.:..::|:       :|.....|:|.       |...:||.:.:
Human  2096 -----NENNAAGYSCGPGT-LKMNGKLSE-------ERTEDTDCDGSPLPEYFTEATKMNGCEEY 2147

  Fly   563 GLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPL--------YQYVPESDEIGSHSNL 619
                         |..:...|.|:. :||...   .:::.:        .:.....|....||.|
Human  2148 -------------CEEKVKSESLIQ-KPQEKK---TDDDEITWGNDELPIERTNHEDSDKDHSFL 2195

  Fly   620 LDGDALFTQSLLLLSDGLASGALLAQYELMYR-------KNPDLAITEARKP----------ANA 667
            .:.:......:.:|..|..:||.|.....:.|       .:.:|...:..||          .|.
Human  2196 TNDELAVLPVVKVLPSGKYTGANLKSVIRVLRGLLDQGIPSKELENLQELKPLDQCLIGQTKENR 2260

  Fly   668 PKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVN-RYIATQGPLASTTTDFWRMVQQ 731
            .||||::|.|||.|||.|.:.  |.||||:::  :||.|... .|||.||||.:|..|||:|:.:
Human  2261 RKNRYKNILPYDATRVPLGDE--GGYINASFI--KIPVGKEEFVYIACQGPLPTTVGDFWQMIWE 2321

  Fly   732 ESSHLLVMLTTVMESGRQKCHQYWP-VTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKD--K 793
            :.|.::.|:|..:|..:.||.:||| :.|:...::.  .:|....:..:...||.|...|:|  .
Human  2322 QKSTVIAMMTQEVEGEKIKCQRYWPNILGKTTMVSN--RLRLALVRMQQLKGFVVRAMTLEDIQT 2384

  Fly   794 HEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENG 858
            .|.|||.|:.:.|||||..||.|:..|.|...:|
Human  2385 REVRHISHLNFTAWPDHDTPSQPDDLLTFISYMR------------------------------- 2418

  Fly   859 GLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEARE 923
                                    .:|:     :.|:|.||||||||:|.||.:|..|.|:....
Human  2419 ------------------------HIHR-----SGPIITHCSAGIGRSGTLICIDVVLGLISQDL 2454

  Fly   924 PVYPLDIVRTMRDQRACMVQNVSQYRFVCECI 955
            .....|:||.||.||..|||...||.|..:.|
Human  2455 DFDISDLVRCMRLQRHGMVQTEDQYIFCYQVI 2486

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	38/203 (19%)
		FERM_N	38..102	CDD:286467	13/63 (21%)
		FERM_M	125..232	CDD:278785	19/116 (16%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	15/93 (16%)
		FA	333..369	CDD:285894	10/35 (29%)
		PDZ_signaling	502..589	CDD:238492	15/93 (16%)
		Y_phosphatase	666..955	CDD:278528	95/292 (33%)
		PTPc	668..955	CDD:238006	94/290 (32%)
PTPN13	XP_011530467.1	KIND	3..190	CDD:214801
		B41	573..781	CDD:214604
		FERM_N	576..638	CDD:286467
		FERM_M	668..781	CDD:278785
		PH-like	777..877	CDD:302622
		PDZ_signaling	1091..1175	CDD:238492
		PTN13_u3	1177..1367	CDD:293207
		PDZ_signaling	1366..1455	CDD:238492
		PDZ	1503..1594	CDD:214570
		PDZ_signaling	1791..1870	CDD:238492	17/113 (15%)
		PDZ_signaling	1888..1966	CDD:238492	14/96 (15%)
		PTPc	2236..2488	CDD:214550	99/317 (31%)
		PTPc	2262..2488	CDD:238006	95/291 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810