DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ptpmeg and PTPN4

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:NP_002821.1 Gene:PTPN4 / 5775 HGNCID:9656 Length:926 Species:Homo sapiens


Alignment Length:1011 Identity:419/1011 - (41%)
Similarity:578/1011 - (57%) Gaps:151/1011 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MFERFRLNNLTRTFRLRGGGPELARDKKTPQRQQCV-TVLFLDDITHTFRIEKRAKGSELLDQVF 64
            |..|||| ...||:.:|..  |||||:   |..:.| .:|.||:....|::.|..:|..|||.||
Human     1 MTSRFRL-PAGRTYNVRAS--ELARDR---QHTEVVCNILLLDNTVQAFKVNKHDQGQVLLDVVF 59

  Fly    65 QYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQE 129
            ::|:|:|:|||||.......|..||:|..|..:||     |...:...|.||||||||||::|||
Human    60 KHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQ-----LKRGSPYSLNFRVKFFVSDPNKLQE 119

  Fly   130 EFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEA 194
            |:||||::||||::||.|:|||.|||..||||:.|||||||::..|:..||||....:.:|..:.
Human   120 EYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYDQSENLSGYLSDYSFIPNQPQDF 184

  Fly   195 ERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLR 259
            |:::.:||:.|.|..||:||:|||..|:.|||||::.|.|.|.:..|:.:||.:.|:|::::.:|
Human   185 EKEIAKLHQQHIGLSPAEAEFNYLNTARTLELYGVEFHYARDQSNNEIMIGVMSGGILIYKNRVR 249

  Fly   260 VNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR-- 322
            :|||.|.|:||:|||.|.||||||:|..|:.:|||||.|.:::..|.|||:|||||:||||.|  
Human   250 MNTFPWLKIVKISFKCKQFFIQLRKELHESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRPL 314

  Fly   323 PHRLSRFLN-ISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRL--------LGAAGGVG 378
            |.:.:.|.: .:|||||.|.||||:|:||..|::....:||.|||||.|        :.:...:.
Human   315 PPQKNFFAHYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLARKLMDWEVVSRNSIS 379

  Fly   379 ---------TSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRP-----HDNKVTSKE 429
                     .|.|..|||  .|..|.........:|:..|.::.....:.|     :....:|.:
Human   380 DDRLETQSLPSRSPPGTP--NHRNSTFTQEGTRLRPSSVGHLVDHMVHTSPSEVFVNQRSPSSTQ 442

  Fly   430 ADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPA-----------YSSGQ---HSP 480
            |:|:..::...|....|                 ..|..:||.           ||..|   .|.
Human   443 ANSIVLESSPSQETPGD-----------------GKPPALPPKQSKKNSWNQIHYSHSQQDLESH 490

  Fly   481 ILLPTTIADAVGHQQPESG---SDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADR 542
            |.....|..:.....|..|   .:|:.||::.||.||:|||||||.|..:||.||:|.|.||||.
Human   491 INETFDIPSSPEKPTPNGGIPHDNLVLIRMKPDENGRFGFNVKGGYDQKMPVIVSRVAPGTPADL 555

  Fly   543 CTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLL---LEEEPLY 604
            |.||:.|||:|::|||||:....|:|||..|:....:.||||:|.|||.....::   ||.||.:
Human   556 CVPRLNEGDQVVLINGRDIAEHTHDQVVLFIKASCERHSGELMLLVRPNAVYDVVEEKLENEPDF 620

  Fly   605 QYVPESDEIGS-HSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAP 668
            ||:||...:.| |.:    |....:|::.|::||.:|.:|.|::.:|||.|.:.::.|:.|.|..
Human   621 QYIPEKAPLDSVHQD----DHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNIS 681

  Fly   669 KNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGA-VNRYIATQGPLASTTTDFWRMVQQE 732
            |||||||||||.|||.|..:  .|||||||:|||||..: :|:|||.||||..|.||||:|..::
Human   682 KNRYRDISPYDATRVILKGN--EDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQ 744

  Fly   733 SSHLLVMLTTVMESGRQKCHQYWP-VTGEELQLAEG-FSVRCLSEKPDETGSFVFREFVL--KDK 793
            .|.::|||||.:|.||.||||||| .||..   :.| :.|.|.||:.:.  :::||:..|  ::|
Human   745 GSSMVVMLTTQVERGRVKCHQYWPEPTGSS---SYGCYQVTCHSEEGNT--AYIFRKMTLFNQEK 804

  Fly   794 HEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENG 858
            :|.|.:..:||:|||||.||.|.:.||:|...||..|                     |..:|  
Human   805 NESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKR---------------------AGKEE-- 846

  Fly   859 GLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEARE 923
                                               ||:||||||||||||||.|:||:.|:|..:
Human   847 -----------------------------------PVVVHCSAGIGRTGVLITMETAMCLIECNQ 876

  Fly   924 PVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY 959
            ||||||||||||||||.|:|..||||||||.|...|
Human   877 PVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY 912

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604 95/197 (48%)
FERM_N 38..102 CDD:286467 26/63 (41%)
FERM_M 125..232 CDD:278785 56/106 (53%)
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 48/93 (52%)
FA 333..369 CDD:285894 20/35 (57%)
PDZ_signaling 502..589 CDD:238492 47/86 (55%)
Y_phosphatase 666..955 CDD:278528 136/293 (46%)
PTPc 668..955 CDD:238006 135/291 (46%)
PTPN4NP_002821.1 B41 30..222 CDD:214604 95/196 (48%)
FERM_C_PTPN4_PTPN3_like 216..310 CDD:270010 48/93 (52%)
FA 325..365 CDD:312314 22/39 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..412 7/33 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 430..475 8/61 (13%)
PDZ_signaling 515..602 CDD:238492 47/86 (55%)
PTPc 682..909 CDD:238006 135/291 (46%)
Substrate binding. /evidence=ECO:0000250 852..858 5/5 (100%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 186 1.000 Domainoid score I3355
eggNOG 1 0.900 - - E2759_KOG0792
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2120
Inparanoid 1 1.050 642 1.000 Inparanoid score I811
Isobase 1 0.950 - 0 Normalized mean entropy S3284
OMA 1 1.010 - - QHG49050
OrthoDB 1 1.010 - - D59173at33208
OrthoFinder 1 1.000 - - FOG0006212
OrthoInspector 1 1.000 - - otm42178
orthoMCL 1 0.900 - - OOG6_104957
Panther 1 1.100 - - O PTHR45706
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5775
SonicParanoid 1 1.000 - - X1974
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.820

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