DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and EPB41L5

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_006712714.1	Gene:	EPB41L5 / 57669	HGNCID:	19819	Length:	740	Species:	Homo sapiens

Alignment Length:	791	Identity:	219/791 - (27%)
Similarity:	335/791 - (42%)	Gaps:	139/791 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSS 102
            |..||....:..:.|:|||.||.||:..:|:|.|.|||||.| .....|..|:|..|..|||...
Human    47 VSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLIESDYFGLRF-MDSAQVAHWLDGTKSIKKQVKI 110

  Fly   103 VSLDNDAVP-LLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQS 166
            .|      | .|..||||:.|:|:.|:||.|||.|.||:|::||.|||.|..:|...||:|.:|:
Human   111 GS------PYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCPFDTAVQLAAYNLQA 169

  Fly   167 ELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDL 231
            ||||::..||.|..:|..:.:..||.|.|..:.|..|.:|||.||.||.|||..||.||:||:|:
Human   170 ELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLNKAKWLEMYGVDM 234

  Fly   232 HRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREP---SENYDTL 293
            |.....:|.:..||::..|:|||:...::..|.|.|:.::.||:....:.:..:.   .|...|.
Human   235 HVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKEQEHTF 299

  Fly   294 LGFGMSSHKHAKALWKSCVEHHSFFRLKRP-----HRLSRFLNISLGSKFYYSGRTELQAVQESK 353
            : |.:...|..|.|||..||||:||||:.|     || |.|  |.|||:|.|||:||.|..:.:|
Human   300 V-FRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHR-SGF--IRLGSRFRYSGKTEYQTTKTNK 360

  Fly   354 QRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTS 418
            .|....  |.|.||||.....    ....:..|..::.|...:.::.:||.....|     .:::
Human   361 ARRSTS--FERRPSKRYSRRT----LQMKACATKPEELSVHNNVSTQSNGSQQAWG-----MRSA 414

  Fly   419 RPHDNKVTSK----EADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHS 479
            .|....::|.    |.:::|:.....|.|...|.|::..:                       :|
Human   415 LPVSPSISSAPVPVEIENLPQSPGTDQHDRKCIPLNIDLL-----------------------NS 456

  Fly   480 PILLPTTIADAVGHQQP-ESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRC 543
            |.||..||.|.:|.... |:...|..:.:.....|           |..|....:.:..| :::.
Human   457 PDLLEATIGDVIGASDTMETSQALNDVNVATRLPG-----------LGEPEVEYETLKDT-SEKL 509

  Fly   544 TPRVCEGDEVLMINGR-DVHGLRHEQVVAMIRDCRH---QASGELLLTVRPQRSAPLLLEEEPLY 604
            .....|...:|..... ||:....|:||.:...|.:   ::.|..::.|.|...:.:|..:....
Human   510 KQLEMENSPLLSPRSNIDVNINSQEEVVKLTEKCLNNVIESPGLNVMRVPPDFKSNILKAQVEAV 574

  Fly   605 QYVPESDEIGSHSNLLDGDALFTQSLL------LLSDGLASGALLAQYELMYRKNPDLAITEARK 663
            ..|.:.|.:.||.|....||....::|      |..:.|.:..|:.
Human   575 HKVTKEDSLLSHKNANVQDAATNSAVLNENNVPLPKESLETLMLIT------------------- 620

  Fly   664 PANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRM 728
            ||::...........|....||..:|                  ::..:|.|....|..|..|.:
Human   621 PADSGSVLKEATDELDALLASLTENL------------------IDHTVAPQVSSTSMITPRWIV 667

  Fly   729 -----VQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQ-LAEGFSV-----RCLSEKPDETGS 782
                 :.|:|.        .|.:|...|...  :||:|.. ..:|.|:     ..|.:....:|.
Human   668 PLCVYLPQQSG--------AMSNGLAGCEML--LTGKEGHGNKDGISLISPPAPFLVDAVTSSGP 722

  Fly   783 FVFREFVLKDK 793
            .:..|.|||.|
Human   723 ILAEEAVLKQK 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	88/194 (45%)
		FERM_N	38..102	CDD:286467	27/63 (43%)
		FERM_M	125..232	CDD:278785	52/106 (49%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	30/96 (31%)
		FA	333..369	CDD:285894	16/35 (46%)
		PDZ_signaling	502..589	CDD:238492	14/90 (16%)
		Y_phosphatase	666..955	CDD:278528	26/139 (19%)
		PTPc	668..955	CDD:238006	26/137 (19%)
EPB41L5	XP_006712714.1	B41	44..235	CDD:214604	88/194 (45%)
		FERM_N	47..109	CDD:286467	27/62 (44%)
		FERM_M	128..235	CDD:278785	52/106 (49%)
		FERM_C_NBL4_NBL5	231..324	CDD:270007	28/93 (30%)
		FA	337..377	CDD:285894	20/43 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910