DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and lnx2b

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_998105.2	Gene:	lnx2b / 564464	ZFINID:	ZDB-GENE-040426-2500	Length:	678	Species:	Danio rerio

Alignment Length:	629	Identity:	129/629 - (20%)
Similarity:	211/629 - (33%)	Gaps:	194/629 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 VDAQKQFKKQCSSVS------LDNDAVPLLEFRVKFFVS------DP---------SRLQEEFTR 133
            ||.|:...:||.:.|      ||..|| |..||.:..:|      .|         .||:||..|
Zfish    82 VDRQRIQLQQCRASSLLVRNLLDKLAV-LCPFRSECELSMQRCELQPHLHNRCPAFKRLREEAER 145

  Fly   134 YQ--FYLQIKRNILLGKLPCSSNTQCL--LASYTVQSELGDFNALEHQPGYLSG---MQLLCDQT 191
            .:  .:.::|.:...|.|..:.:.|.:  .|..:..||.|..|     |.:..|   ..|.|...
Zfish   146 KKRPSWNELKGSKSDGDLADAKSAQTIGRTAQLSAPSEPGLVN-----PAFEEGEDDTPLRCSLV 205

  Fly   192 TEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLG----------- 245
            .||  .|.||.:...|:            ...|.:.|          ||:..||
Zfish   206 AEA--TVVELFREDPGE------------DLGLRIVG----------GKDTPLGNIVIQEIVRDS 246

  Fly   246 -VSAVGLLV-FQHSLRVN-----TFSWSKMVKV----------------SFK-RKDFFIQLRREP 286
             |:..|.|. ..|.|.||     :.|.|:.:.|                .|| |.:...|....|
Zfish   247 LVARDGKLAPGDHILEVNDVSLASISHSRAIAVIRQPCSRLRLTVMQEKGFKPRPEHHTQPSASP 311

  Fly   287 -------SENYDTLLGFGMSSHKHAKALWKSCV---EHHSFFRLK-RPHRLS----------RFL 330
                   ::|:.|::...:..|:.::||....:   |....|.|. .|..|:          :.|
Zfish   312 PTQSPSTNQNHGTVIQVTLVKHERSEALGIKLIRKSEEPGVFILDLLPGGLAAKDGKLRNNDKVL 376

  Fly   331 NISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSE 395
            .|:.....:.:..:..|.:|.|:.  |::.|.:|...   :...||.|.|..:...|..|:....
Zfish   377 GINGQDLRHGTPESAAQIIQASEM--RVNFVVMRLQD---VSEEGGEGQSRGARRVPEPQYFRRH 436

  Fly   396 SANSHNNGKPAG-AGTILTITKTSRPHDN-----------------KVTSKEADSMPRKAWEQQS 442
            |  .:....|.| :....|:|....|..:                 .:||.:......:....::
Zfish   437 S--EYMKEPPGGFSSQEKTVTLKKEPRQSLGITIAGGRDCRSRLPVYITSVQPVGCLHRDGTVKT 499

  Fly   443 DEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPT--TIADAVGHQQPESGS--DLI 503
            .  |:.|.:..|:.....:..|    :....:....|.:.|..  |.||. ..|..||||  |:.
Zfish   500 G--DVLLSINGIDLTHLTYNEA----VTVLKTQTAQSTVTLRVIQTFADD-EEQDGESGSREDMD 557

  Fly   504 T------------------------------IRLQADEQGRYGFNVKGGVDLS---LPVQVSKVV 535
            |                              |.|.......:||::.||.:.|   .|..:..:|
Zfish   558 TMEGPKDDDINWVPLWTRWLGLPSCIHWCRDIMLMKTNSESWGFSIVGGYEESRGQQPFFIKTIV 622

  Fly   536 PHTPAD-----RCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIR 574
            |.|||.     :|      |||::.:||....|:.:..::.|::
Zfish   623 PGTPAYFDGRLKC------GDEIVAVNGVTTVGMNNSSLIPMLK 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	41/169 (24%)
		FERM_N	38..102	CDD:286467	5/11 (45%)
		FERM_M	125..232	CDD:278785	26/113 (23%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	27/138 (20%)
		FA	333..369	CDD:285894	6/35 (17%)
		PDZ_signaling	502..589	CDD:238492	22/111 (20%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
lnx2b	NP_998105.2	RING	46..82	CDD:214546	129/629 (21%)
		PDZ_signaling	210..291	CDD:238492	20/102 (20%)
		PDZ_signaling	325..406	CDD:238492	14/82 (17%)
		PDZ_signaling	451..537	CDD:238492	11/91 (12%)
		PDZ_signaling	587..671	CDD:238492	21/80 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910