DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and FGD6

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_060821.3	Gene:	FGD6 / 55785	HGNCID:	21740	Length:	1430	Species:	Homo sapiens

Alignment Length:	827	Identity:	170/827 - (20%)
Similarity:	270/827 - (32%)	Gaps:	238/827 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 YLSGMQLLCDQTTEAERKVGELHKLHRGQL---PADAEYNYLEHAK-----------RLELYG-- 228
            |:|.|   |..::|...|:|....|...||   |.:...| ||::|           :.:|||
Human   105 YISPM---CSCSSECIHKLGHRENLCVKQLVLEPLEMNEN-LENSKIDETLTIKTRSKCDLYGEK 165

  Fly   229 -------------------------------IDLHRATDSNGKELQLGVSAVGLLVFQHS-LRVN 261
                                           ...||.|||  .|:..|.::.|....:.: |..:
Human   166 AKNQGGVVLKASVLEEELKDALIHQMPPFISAQKHRPTDS--PEMNGGCNSNGQFRIEFADLSPS 228

  Fly   262 TFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRL 326
            ..|:.|:.    ......:||..:..|:::|.......|:        :|.:......|:...|.
Human   229 PSSFEKVP----DHHSCHLQLPSDECEHFETCQDDSEKSN--------NCFQSSELEALENGKRS 281

  Fly   327 SRFLNISLGSKFYYSGRTELQAVQESKQRG--RIH------KVFVRSPSK----RLLGAAGGVGT 379
            :...:..:..|            .|.|..|  .||      |.....|.|    ||| ....|.|
Human   282 TLISSDGVSKK------------SEVKDLGPLEIHLVPYTPKFPTPKPRKTRTARLL-RQKCVDT 333

  Fly   380 SGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKE-ADSMP--RKA---W 438
            ...|...|....|.|.....::          |.|.|.|..|.|.:..:| .|.|.  .|:   .
Human   334 PSESTEEPGNSDSSSSCLTENS----------LKINKISVLHQNVLCKQEQVDKMKLGNKSELNM 388

  Fly   439 EQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLI 503
            |..||..|:......:...|..||..:|       |..:.|.:...:|..|         ||
Human   389 ESNSDAQDLVNSQKAMCNETTSFEKMAP-------SFDKDSNLSSDSTTVD---------GS--- 434

  Fly   504 TIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQ 568
            ::.|..||  ..|| ::..|.:|||.|:...        |...:..|..:    |.....::.|.
Human   435 SMSLAVDE--GTGF-IRCTVSMSLPKQLKLT--------CNEHLQSGRNL----GVSAPQMQKES 484

  Fly   569 VVAMIRDCRHQASGELLLTVRPQR-SAPL-----------LLEEEPLYQYVPESDEIGSHSNLLD 621
            |:......|       ::..:||| |.|.           |||:..    .|.|:|..|..:|
Human   485 VIKEENSLR-------IVPKKPQRHSLPATGVLKKAASEELLEKSS----YPSSEEKSSEKSL-- 536

  Fly   622 GDALFTQSLLLLSDGLASGA------------LLAQYELMYRKNPD----LAITEARKPANA-PK 669
             :....|.|...:.|::|..            .|....|.:..||:    :.::...:|:.| .|
Human   537 -ERNHLQHLCAQNRGVSSSFDMPKRASEKPVWKLPHPILPFSGNPEFLKSVTVSSNSEPSTALTK 600

  Fly   670 NRYRDISPYD---CTRVSLVNSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDFWRMVQQ 731
            .|.:.:|..|   ||:....::....:.....:.:.|..            :.|....||    .
Human   601 PRAKSLSAMDVEKCTKPCKDSTKKNSFKKLLSMKLSICF------------MKSDFQKFW----S 649

  Fly   732 ESSHLLVMLTTVMESGRQK-CHQYWP--VTGEELQ-------LAEGFSVRCLSEKPDETGSFV-- 784
            :||.|....|..:.||.|| ....|.  :.|||.:       ..|.:|:....::....|...
Human   650 KSSQLGDTTTGHLSSGEQKGIESDWQGLLVGEEKRSKPIKAYSTENYSLESQKKRKKSRGQTSAA 714

  Fly   785 --FREFVLKDKHEQRH-IHHMQYLAWPDHCVPSDPNL--FLEFTER-----VRAARNRTLLQEIE 839
              .|...|.|:...|. .....|.:....|.|...|:  :.|..|.     :.|.|.   .||:|
Human   715 NGLRAESLDDQMLSRESSSQAPYKSVTSLCAPEYENIRHYEEIPEYENLPFIMAIRK---TQELE 776

  Fly   840 ESLKQVRLMDADADADE--------NGGL-MRERKCAASNGATPEDE 877
            .. ....:.||||:..|        :|.| :..|...:|:||:.|::
Human   777 WQ-NSSSMEDADANVYEVEEPYEAPDGQLQLGPRHQHSSSGASQEEQ 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	18/98 (18%)
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785	18/98 (18%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	20/127 (16%)
		FA	333..369	CDD:285894	9/47 (19%)
		PDZ_signaling	502..589	CDD:238492	16/86 (19%)
		Y_phosphatase	666..955	CDD:278528	53/247 (21%)
		PTPc	668..955	CDD:238006	52/244 (21%)
FGD6	NP_060821.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..351		6/20 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	516..538		8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	695..739		7/43 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	800..869		7/23 (30%)
		RhoGEF	875..1059	CDD:279015
		PH1_FGD6	1077..1199	CDD:275436
		PH	1092..1183	CDD:278594
		FYVE_FGD6	1217..1277	CDD:277282
		PH	1336..1426	CDD:278594
		PH2_FGD5_FGD6	1336..1424	CDD:270057
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910