DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and trioa

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_021323750.1	Gene:	trioa / 557667	ZFINID:	ZDB-GENE-060503-334	Length:	3115	Species:	Danio rerio

Alignment Length:	1215	Identity:	225/1215 - (18%)
Similarity:	385/1215 - (31%)	Gaps:	372/1215 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PELARDK------------KTPQRQQCVTV--------LFLDDITHTFRIEKRAKGS-------- 57
            |:...||            :||...:.|:.        :.|:|...|..:|:....|
Zfish  1920 PDAQDDKTSSRLSVRPSSSETPSAAELVSAIEELVKSKMALEDRPSTLSVEQGDSSSPSFNPSDN 1984

  Fly    58 ELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSV------SLDNDAVP----- 111
            .||.......|:.||...  .|.::...::..::.::.:.:..|.|      .:..|.||
Zfish  1985 SLLSSSSPIDEIEERKTG--FFKKRHYVLLELIETERDYVRDLSLVVEGYMARMREDGVPDDMKG 2047

  Fly   112 -----------LLEFRVKFF-------VSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCL 158
                       :.::...||       :.||.||...|.:::      |.:.:..:.|.:..:
Zfish  2048 KDKIVFGNIQQIYDWHKDFFLGELEKCLEDPDRLGPLFLKHE------RRLHMYIVYCQNKPK-- 2104

  Fly   159 LASYTVQSELGD--FNALEHQPGY--------------LSGMQLLCDQTTEAERKVG----ELHK 203
              |..:.||..|  |..|:.:.|:              :...|||.....:..:|:|    ||.|
Zfish  2105 --SEHIVSEYIDTYFEDLKQRLGHRLQITDLLIKPVQRIMKYQLLLKDFLKFSKKIGTDSIELEK 2167

  Fly   204 LHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKM 268
            ............|.:.:..||:  |.|        ||     :.|.|.|:.|.:..|.......:
Zfish  2168 AVEVMCIVPKRCNDMMNVGRLQ--GFD--------GK-----IVAQGRLLLQDTFMVAEPEGGLL 2217

  Fly   269 VKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCV--------------------- 312
            .::..:|...|.|:... ||..|...||.|..:.:..::..:|:
Zfish  2218 NRMKERRVFLFEQIVIF-SEPLDKKRGFSMPGYLYKYSIKVNCLGLEDSVDGDPCKFALTSRTSN 2281

  Fly   313 EHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGV 377
            .....|.|...|...|.:.:...|:...|.|..|.|:.......|.|   |..|     |.:|..
Zfish  2282 SSKDAFILHSSHPGVRQVWMLQISQILESQRNFLNALTSPIDYQRNH---VEGP-----GVSGSG 2338

  Fly   378 GTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRP--------------------HD 422
            ..:|.|||..|....|.        |.|||.|:....::..:|                    ||
Zfish  2339 VQAGGSGGQMMAPGGGV--------GVPAGPGSRSRPSRIPQPSRLPQPLRHHSPALGPGAHEHD 2395

  Fly   423 -------------NKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMP---- 470
                         ::..|....:.|....:..:..:..|.|....|...:....|:.:|:.
Zfish  2396 GPDKLSGMSPRPLSRGPSPSCTTEPEPKVKLPASPHPKQTDSQQTESPAKEIPRATVAPLALVKP 2460

  Fly   471 -PAYSSGQHSPILLPTTIADAVG--HQQPESGSDLITIRLQADEQGR-YGFNVKGGV--DLSLP- 528
             |...|...||:..| ...|::.  ...|::||......:.|....| ..|...|..  .||.|
Zfish  2461 RPGTVSPMASPLATP-AFKDSIPPCSPGPKTGSSSFWSSVPASPASRPASFTFPGDACDTLSRPN 2524

  Fly   529 -VQVSKVVPHT-PADRCTPRVCEGDEVLMINGRDVHG------------LRHEQVVAMIRDCRHQ 579
             .|..:...|: .|||.:  .|.......|.....:|            |..:..||:..|..:.
Zfish  2525 HNQSQRHSTHSKDADRMS--TCSSTSEQSIQSTQSNGSESSSSSNISTMLVTQDYVALKEDEINV 2587

  Fly   580 ASGELLLTVRPQRSAPLLL-----EEEPLYQ-YVPESDEIGSHSNLLDGDALFTQSLLLLSDGLA 638
            ..||::..:...:....|:     |:.|..: ::|  ..:..|::.:..||         .||..
Zfish  2588 GQGEVVQILASNQQNMFLVFRAATEQCPAAEGWIP--GYVLGHTSAIIPDA---------PDGTI 2641

  Fly   639 SGALLAQY--ELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNM 701
            :....:.:  .|..||..:....:.:|.|.. :|.||.      :|..|.|.::...:|.||:..
Zfish  2642 NRKSSSSWHTSLRIRKKSEKREKDNKKEAKL-ENGYRK------SREGLTNKVSVKLLNPNYIYD 2699

  Fly   702 EIPGGAVNRYIATQGPLASTTTD-------------------FWRMVQQES-------------- 733
            .:|...|        ||:..|.|                   .|:..:|::
Zfish  2700 VLPEFLV--------PLSDVTCDKGECVTLRCKVCGRPKATVTWKGPEQKTLTNNGHFSIAYSET 2756

  Fly   734 --SHLLVMLTTVMESGRQKC-------------------------HQYWPVTGEEL-----QLAE 766
              :.|.::..|..:.|...|                         ...|....|..     :|..
Zfish  2757 GEATLRIVGVTSEDDGSYTCIATNDIGSVASSASLRVLGTTSDGIRVMWKDNFESFYTEVAELGR 2821

  Fly   767 G-FSV--RCLSEKPDETGS-------FVFREFVLKDK--HEQRHIHHMQYLAWPDHCV------- 812
            | |||  ||     |:.||       ||.::.:.:|:  ||...:..:|:    .|.|
Zfish  2822 GRFSVVKRC-----DQRGSKRTVAVKFVNKKLMKRDQVTHEFSVLQRLQH----PHLVRLLDTFE 2877

  Fly   813 ----------PSDPNLFLEF-------TERVRAARNRTLLQEIEESLKQVRLMDADADADENGGL 860
                      .||....|::       ||...|...|.:|:.: :.|...|::..|...:   .|
Zfish  2878 TSSSYALVLEMSDQGRLLDYIVSWGNLTEEKVAFYLRDILEAL-QYLHNCRIVHLDLKPE---NL 2938

  Fly   861 MRER-------KCAASNGATPEDETPVSTSVHQCISA---ANPPVI----VHCSAGIGRTGVL-- 909
            :.|:       |......|...:.||.   ||..:.:   |.|.::    |..|:.:...|||
Zfish  2939 VVEQSPSQPLVKLTDFGDAVQLNSTPY---VHPLLGSPEFAAPELVLGDPVSLSSDLWSLGVLTY 3000

  Fly   910 ILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQYR--FVC 952
            :::..|...::.......|:|.|..........|.|||..  |:|
Zfish  3001 VMLSGASPFLDESVEETCLNICRLDFSFPDDYFQGVSQAARDFMC 3045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	46/261 (18%)
		FERM_N	38..102	CDD:286467	11/79 (14%)
		FERM_M	125..232	CDD:278785	25/126 (20%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	20/114 (18%)
		FA	333..369	CDD:285894	9/35 (26%)
		PDZ_signaling	502..589	CDD:238492	21/104 (20%)
		Y_phosphatase	666..955	CDD:278528	77/406 (19%)
		PTPc	668..955	CDD:238006	77/404 (19%)
trioa	XP_021323750.1	SEC14	61..199	CDD:214706
		SPEC	212..447	CDD:238103
		SPEC	343..589	CDD:238103
		SPEC	590..806	CDD:238103
		SPEC	810..1037	CDD:238103
		SPEC	931..1160	CDD:238103
		SPEC	1166..1266	CDD:197544
		RhoGEF	1316..1488	CDD:238091
		PH1_Kalirin_Trio_like	1495..1627	CDD:270060
		SH3_Kalirin_1	1695..1754	CDD:212786
		SH3-RhoG_link	1752..2000	CDD:318750	15/79 (19%)
		RhoGEF	2007..2180	CDD:238091	29/182 (16%)
		PH2_Kalirin_Trio_p63RhoGEF	2185..2324	CDD:270061	30/154 (19%)
		Atrophin-1	<2364..2523	CDD:331285	25/159 (16%)
		SH3_Kalirin_2	2570..2628	CDD:212787	10/59 (17%)
		I-set	2702..2793	CDD:254352	12/98 (12%)
		PKc_like	2805..3067	CDD:328722	56/257 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910