DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ptpmeg and FRMD4A

DIOPT Version :9

Sequence 1:NP_001163309.2 Gene:Ptpmeg / 38059 FlyBaseID:FBgn0261985 Length:974 Species:Drosophila melanogaster
Sequence 2:XP_006717520.1 Gene:FRMD4A / 55691 HGNCID:25491 Length:1110 Species:Homo sapiens


Alignment Length:937 Identity:176/937 - (18%)
Similarity:320/937 - (34%) Gaps:264/937 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    38 VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQ-----FK 97
            |..|||......::.:....||||.|..:..|.|::|||:.|..:.|. :.|:...::     |.
Human    57 VHLLDDRKLELLVQPKLLAKELLDLVASHFNLKEKEYFGIAFTDETGH-LNWLQLDRRVLEHDFP 120

  Fly    98 KQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASY 162
            |:...|        :|.|.|:|::...|.|::..|...|:|..|..|....:...|.....||||
Human   121 KKSGPV--------VLYFCVRFYIESISYLKDNATIELFFLNAKSCIYKELIDVDSEVVFELASY 177

  Fly   163 TVQSELGDFNALEHQPGYLSGMQLLCDQTTE-------------------------------AER 196
            .:|...|||:         |.:..|.|:|.|                               .|.
Human   178 ILQEAKGDFS---------SFLGPLYDRTKEQRATNEVVRSDLKKLPALPTQALKEHPSLAYCED 233

  Fly   197 KVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRV- 260
            :|.|.:|...||....|..||:...:.|..||:..:...|..|....||:|..|:..:.:..:| 
Human   234 RVIEHYKKLNGQTRGQAIVNYMSIVESLPTYGVHYYAVKDKQGIPWWLGLSYKGIFQYDYHDKVK 298

  Fly   261 --NTFSWSKMVKVSFKRKDFFIQLR--REPSENYDTLLGFGMSSHKH------AKALWKSCVEHH 315
              ..|.|.::..:.|:.|.|.:::.  |..|....|....|::.|..      .|::|...:..|
Human   299 PRKIFQWRQLENLYFREKKFSVEVHDPRRASVTRRTFGHSGIAVHTWYACPALIKSIWAMAISQH 363

  Fly   316 SFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGV--G 378
            .|: |.|....|:.          ::.|:..:...:..:.|.:     ::.....:|:.|.:  |
Human   364 QFY-LDRKQSKSKI----------HAARSLSEIAIDLTETGTL-----KTSKLANMGSKGKIISG 412

  Fly   379 TSGS--SGGTPMQQH----SGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKA 437
            :|||  |.|:..::|    .||:.::|..:.|                .|.....|.......:.
Human   413 SSGSLLSSGSGARRHCILLPGSQESDSSQSAK----------------KDMLAALKSRQEALEET 461

  Fly   438 WEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDL 502
            ..|:.:|..        :.|.|..|.....|:......|:..||     :...:|          
Human   462 LRQRLEELK--------KLCLREAELTGKLPVEYPLDPGEEPPI-----VRRRIG---------- 503

  Fly   503 ITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHE 567
              ...:.|||                    |::|            :|:|.      ::..|..|
Human   504 --TAFKLDEQ--------------------KILP------------KGEEA------ELERLERE 528

  Fly   568 -QVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLY----QYVPESDEIGSHSNLLDGDALFT 627
             .:.:.|.:...:.:.:      |..|..|..:.:..|    :.:.|.:...:.:.:..|.....
Human   529 FAIQSQITEAARRLASD------PNVSKKLKKQRKTSYLNALKKLQEIENAINENRIKSGKKPTQ 587

  Fly   628 QSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPY--DCTRVSLVNSLT 690
            ::.|::.||..:....:..:.:..::.|..:|....|.::|   ::.:.|.  ...|.....||.
Human   588 RASLIIDDGNIASEDSSLSDALVLEDEDSQVTSTISPLHSP---HKGLPPRPPSHNRPPPPQSLE 649

  Fly   691 G----DYINANYVNMEIPGGAVNRYIATQGPL------ASTTTDFWRMVQQESSHLLVMLTTVME 745
            |    .|...:|               .:.|:      .|:..:.:..|::.|||          
Human   650 GLRQMHYHRNDY---------------DKSPIKPKMWSESSLDEPYEKVKKRSSH---------- 689

  Fly   746 SGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAW-PD 809
             .....|:.:|.||...:...|.:  .|...|                  .|.:.|     | ..
Human   690 -SHSSSHKRFPSTGSCAEAGGGSN--SLQNSP------------------IRGLPH-----WNSQ 728

  Fly   810 HCVPSDPNLFLEFTERVRAAR----NRTLLQEI-------EESLK-QVRLMDADADADENGGLMR 862
            ..:||.|:|.:.....|.:.|    :.|.|..:       ..||: |.:|:.::.|.....  ..
Human   729 SSMPSTPDLRVRSPHYVHSTRSVDISPTRLHSLALHFRHRSSSLESQGKLLGSENDTGSPD--FY 791

  Fly   863 ERKCAASNGATPEDE----TPVSTSVH 885
            ..:..:|||:.|.|:    |..|:|.|
Human   792 TPRTRSSNGSDPMDDCSSCTSHSSSEH 818

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PtpmegNP_001163309.2 B41 35..232 CDD:214604 57/229 (25%)
FERM_N 38..102 CDD:286467 19/68 (28%)
FERM_M 125..232 CDD:278785 33/137 (24%)
FERM_C_PTPN4_PTPN3_like 226..320 CDD:270010 23/104 (22%)
FA 333..369 CDD:285894 2/35 (6%)
PDZ_signaling 502..589 CDD:238492 10/87 (11%)
Y_phosphatase 666..955 CDD:278528 46/249 (18%)
PTPc 668..955 CDD:238006 46/247 (19%)
FRMD4AXP_006717520.1 B41 54..269 CDD:214604 57/229 (25%)
FERM_N 57..118 CDD:286467 17/61 (28%)
FERM_M 140..269 CDD:278785 33/137 (24%)
FERM_C_FRMD4A_FRMD4B 265..375 CDD:270012 24/110 (22%)
DUF3338 429..551 CDD:288652 28/206 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.