DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and tln2a

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_009301497.1	Gene:	tln2a / 556842	ZFINID:	ZDB-GENE-040724-263	Length:	2548	Species:	Danio rerio

Alignment Length:	1109	Identity:	213/1109 - (19%)
Similarity:	374/1109 - (33%)	Gaps:	275/1109 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FRLRGGGPELARDKKTPQRQQ----CVTVLFLDD--------ITHTFRI---------------- 50
            :.||.|.....:.|:.||:.:    .|..:.:||        :|...||
Zfish    73 YMLRNGDILEYKKKQRPQKVKMLDGAVKTIMVDDSKTVGELLVTICSRIGITNYEEYSLIQETVE 137

  Fly    51 EKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEF 115
            ||:.:|:..|.:....|. .||....|.......|.:.|:|..:.|::|    .::.....||
Zfish   138 EKKDEGTGTLKKDRTLLR-EERKMEKLKAKLHTDDDLNWLDHGRTFREQ----GVEESETLLL-- 195

  Fly   116 RVKFFVS-------DPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNA 173
            |.|||.|       ||.:|.      ..|:|.:.:||.|..|.|.:..|.......|.:.|....
Zfish   196 RRKFFYSDQNVDSRDPVQLN------LLYVQARDDILNGSHPVSFDKACEFGGIQTQIQFGPHIE 254

  Fly   174 LEHQPGYLSGMQLLCDQTTE---AERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRAT 235
            .:|:.|:|...:.|..:..:   ||:|:.:.||........:|:..|::.|:.|..||:......
Zfish   255 HKHKTGFLDLKEFLPKEYIKQRGAEKKIFQEHKGCGEMTEIEAKVKYVKLARSLRTYGVSFFLVK 319

  Fly   236 DSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDF-----FIQLRREPSENYDTLLG 295
            :....:.:|....:|:            :...:::|..|.||.     ...::|..:......|.
Zfish   320 EKMKSKNKLVPRLLGV------------TKESVMRVDEKTKDVVQEWPLTTVKRWAASPKSFTLD 372

  Fly   296 FGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSK-----FYYSGRTELQAVQES--- 352
            ||.....:...   ...|.....:|     ::.:::|.|..|     |...|..|...::||
Zfish   373 FGEYQESYYSV---QTTEGEQISQL-----IAGYIDIILKKKQSKDRFGLEGDEEATMLEESVSP 429

  Fly   353 -------KQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGT---PMQQHSGSESANSH----NNG 403
                   :|..|:.:|...|.:...:..:|.||....:.||   |.||.:..:....|    :..
Zfish   430 KKSTILQQQFNRVGRVEHGSVALPGILRSGSVGAETLNMGTMPAPQQQITTGQMHLGHMPPLSAA 494

  Fly   404 KPAGAGTILTITKTSRPHDNKVTSKE-----ADSMPRKAW-EQQSDE--YDIQLDVGFIEQCTR- 459
            :.|..|||.|..:..:...:.:...|     .|.|..|.| :.:.||  :||...|..|...|.
Zfish   495 QQALVGTINTSMQAVQQAQDDLEEVEELPPLGDDMASKMWIQNKMDESKHDIHSQVDAITAGTAS 559

  Fly   460 --RFESASPSP------------------------------MPPAYSSGQHSPILLPTTIADAVG 492
              ...:..|:.                              |.....|| |..:....|:..||.
Zfish   560 VVNLTAGDPTDTDYTAVGCAITTISSNLTEMSKGVKLLAALMEDEVGSG-HDLMRAARTLTGAVS 623

  Fly   493 H----QQPESGSDLITIRLQADEQG--------RYGFNVKGGVDLSLPVQVSKVVPHTPADRCTP 545
            .    .:|.||....|:...|...|        :.|.|........:.:.::|.|.:..|
Zfish   624 DLLKAVEPTSGEPRQTVLTAAGSIGQASGDLLRQIGENETDERFQDVLMNLAKAVANAAA----- 683

  Fly   546 RVCEGDEVLMINGRDV-----HGLRHEQVVAMIRDCRHQASGELLL---TVRPQRSAPLLLEEEP 602
                   ::::..::|     ..:...:|:|....|....| :|:.   .|.|..|:|:..|:
Zfish   684 -------MMVLKAKNVAQVSEDSVMQNRVIAAATQCALSTS-QLVACAKVVSPTISSPVCQEQ-- 738

  Fly   603 LYQYVPESDEIGSHSNLLDGDALFTQS--------LLLLSDGLASGALLAQYELMYRKNPDLAIT 659
                            |::...|..:|        |...|||....|:.|...::.:...|| :|
Zfish   739 ----------------LIEAGKLVDRSVEGCVKACLSATSDGELLKAVSAAAGIVTQALSDL-LT 786

  Fly   660 EARKPANAPKNRYRDISPYDCTRVSLVN-----------------------SLTGDYINANYVNM 701
            ..|..|    .|...|..||....:::|                       ..|.|.:||...:.
Zfish   787 HVRNYA----TRGEPIGRYDQATDTIMNVTENIFSSMGDAGEMVRQARVLAQATSDLVNAMRSDA 847

  Fly   702 EIPGGAVN--RYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQL 764
            |:.....|  :.:|....||..|.   |||:....   .......|..:||..:    ..|.|::
Zfish   848 EVEVDVNNSKKLLAAAKLLADATA---RMVEAAKG---AAAYPENEDQQQKLRE----AAEGLRV 902

  Fly   765 AEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAA 829
            |...:.:...:|     ..:.|   |::..:|......|.:|...:...|:.|          .|
Zfish   903 ATNAAAQNAIKK-----KLITR---LENAAKQAAAAATQTIAASQNAAASNKN----------TA 949

  Fly   830 RNRTLLQE---IEESLKQ-VRLMDADADADENGGLMRERKCAASNGATPEDE--TPVSTSVHQCI 888
            .::.|:|.   :.:.:.| |:.:.......|:|........|:.|...|..:  :...:||....
Zfish   950 AHQQLVQSCRAVADHIPQLVQGVRGSQGQPEDGSAQLALIIASKNFLQPGSKMVSSAKSSVPTVT 1014

  Fly   889 SAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDI------VRTMRD--QRACMVQNV 945
            ..|....:..|:..:..|    |.:...|...|.|...|::|      |:|:::  |.|.|..:.
Zfish  1015 DQAAAMQLGQCAKNLATT----LAELRTAAQTAHEACGPMEIDSALIAVQTLKNELQDAKMAASE 1075

  Fly   946 SQYR 949
            .|.:
Zfish  1076 GQLK 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	54/230 (23%)
		FERM_N	38..102	CDD:286467	18/87 (21%)
		FERM_M	125..232	CDD:278785	26/109 (24%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	13/98 (13%)
		FA	333..369	CDD:285894	11/50 (22%)
		PDZ_signaling	502..589	CDD:238492	14/102 (14%)
		Y_phosphatase	666..955	CDD:278528	59/323 (18%)
		PTPc	668..955	CDD:238006	59/321 (18%)
tln2a	XP_009301497.1	FERM_f0	4..85	CDD:293120	3/11 (27%)
		B41	90..316	CDD:214604	55/238 (23%)
		FERM_N	92..188	CDD:286467	19/100 (19%)
		FERM_M	206..316	CDD:278785	28/115 (24%)
		FERM_C_Talin	312..403	CDD:269973	14/110 (13%)
		Talin_middle	494..655	CDD:286254	31/161 (19%)
		talin-RS	1045..>1174	CDD:213393	9/35 (26%)
		talin-RS	1656..1827	CDD:213393
		VBS	1850..1974	CDD:286057
		talin-RS	1975..2141	CDD:213393
		ILWEQ	2343..2538	CDD:214607
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910