DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and fgd4a

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001171404.1	Gene:	fgd4a / 556216	ZFINID:	ZDB-GENE-050420-347	Length:	728	Species:	Danio rerio

Alignment Length:	654	Identity:	115/654 - (17%)
Similarity:	212/654 - (32%)	Gaps:	197/654 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   355 RGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESAN--SHNNGKPAGAGTILTITKT 417
            :||:..:..|....|        .|.|...|||.:|.|.|.:.:  ..|..:|...      |..
Zfish    12 KGRVSNLISRFEENR--------HTDGRREGTPPKQVSRSPNCSPPRKNYQRPREQ------TSD 62

  Fly   418 SRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPIL 482
            |.||       .|...|.....:.:.:.|.:.|:          |..:.:|:|.|
Zfish    63 SSPH-------HALKPPNGVLAKMNRDRDRERDM----------EGVTHAPVPIA---------- 100

  Fly   483 LPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRV 547
                                     :.::||....:   .|||                  |.|.
Zfish   101 -------------------------RINKQGLLNGD---SVDL------------------TKRE 119

  Fly   548 CEGDEVLMINGRDVH-GLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESD 611
            ...:|  .::..||| ....|:.....|....|:....:.::..|:..    .|:.||:...|
Zfish   120 ITEEE--CVDSPDVHLNQAKEEEEQEKRKVSEQSDIVRMNSIPEQKET----NEQKLYKIANE-- 176

  Fly   612 EIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDIS 676
                   ||..:..:...|.||.            ::.|.|    .:.||||          |..
Zfish   177 -------LLQTEKAYVARLNLLD------------KVFYTK----LMEEARK----------DTF 208

  Fly   677 PYDCTRVSLVNSLTGDYINANYVNMEIPG--GAVNRYIATQ--GPLASTTTDFWRMVQQ---ESS 734
            |.|..: |:.:::|.  |||.:....:|.  ..:..:.:|.  |.:....|.|.:|..:   ...
Zfish   209 PVDVVK-SIFSNITS--INAFHSQFLLPDLEKRMGEWTSTPRIGDILQKLTPFLKMYAEYVRNFD 270

  Fly   735 HLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLK-----DKH 794
            |.:.:|       :|:..:..|.....|.:          :..:..|:...:..:|:     .::
Zfish   271 HAMDLL-------KQRIDRSPPFKAIILDI----------QSQEVCGNLTLQHHMLEPVQRVPRY 318

  Fly   795 EQRHIHHMQYLAWPDHCVPSDPNLFLEF--------TERVRAARNRTLLQEIEESL-KQVRLMDA 850
            |.....:::.|. |:|....|....||.        ...:|...|...|.||.|.| ::..:::.
Zfish   319 EMLLKDYLKKLP-PEHMDRRDAEKSLEIIGMAATHSNTAIRKTENLKKLLEIYEMLGEEEDIVNP 382

  Fly   851 DADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTA 915
            ..:..:.|.::   |.||.|          ::::.:.:...| .::::|.......|....:.|.
Zfish   383 SNELIKEGHIL---KLAARN----------TSAMDRYLFLFN-NMLLYCVPKFSLVGQKFTVRTR 433

  Fly   916 LAL--MEAREPV---YPLDI-----VRTMRDQRACMVQNVSQYRFVCECICAAYMKISRSSAAIN 970
            :.:  |..:|..   ||...     .||:..|.:..:...|..:...|.|..:..|.....:||.
Zfish   434 IGIEGMNVKETFNEDYPHTFQVSGKERTLELQASSKLDKESWIKAFTETIDISLQKNETFKSAIK 498

  Fly   971 DDED 974
            |.|:
Zfish   499 DTEE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894	3/13 (23%)
		PDZ_signaling	502..589	CDD:238492	14/87 (16%)
		Y_phosphatase	666..955	CDD:278528	53/319 (17%)
		PTPc	668..955	CDD:238006	53/317 (17%)
fgd4a	NP_001171404.1	RhoGEF	173..346	CDD:279015	40/228 (18%)
		PH	386..483	CDD:278594	18/110 (16%)
		PH1_FDG4	386..479	CDD:275434	17/106 (16%)
		FYVE_FGD1_2_4	516..580	CDD:277280
		PH2_FGD1-4	601..703	CDD:270056
		PH	609..703	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910