DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and ptprk

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_021324239.1	Gene:	ptprk / 555348	ZFINID:	ZDB-GENE-030131-9834	Length:	1500	Species:	Danio rerio

Alignment Length:	884	Identity:	190/884 - (21%)
Similarity:	302/884 - (34%)	Gaps:	342/884 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   276 KDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEH--------------HSF---FRLKRP 323
            |:|   :|..|||:..:|             .||..:|.              |||   ..|.||
Zfish   494 KEF---VRSTPSEDKISL-------------QWKEPLEPNGIITQYEISYSSVHSFDPSVPLLRP 542

  Fly   324 HRL-------SRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSG 381
            ..|       ||: |.:|    .:.|.|              ::..:|:.:.:..|....:..:.
Zfish   543 PLLVSLPWNTSRY-NFTL----LHPGTT--------------YQFLIRASTSKGFGPPTTLNVTT 588

  Fly   382 SSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWE---QQSD 443
            :.....::::.|||::.:.         |..|||...:|       .:|...|..|::   ::.:
Zfish   589 NISAPTLEEYDGSEASLNE---------TATTITVLLKP-------AQAKGAPISAYQIVVKEIN 637

  Fly   444 EYDIQLDVGFIEQCTRR---FESASPSPMPPAYSS-----GQHSPILLPTTIAD----------- 489
            .:..:.:.|..| |.|.   ::||..|.:|..:::     ....|  ||.|:.|
Zfish   638 PHRGRREAGGGE-CYREPVSYQSAVSSGLPYYFAAEIPPRNLQEP--LPFTVGDNKTYHGYWNAP 699

  Fly   490 ------------AVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADR 542
                        ||...:.||.:..:.:..            ||.      .:..:|:| .||.
Zfish   700 LAPRKDYNIYFQAVSRVEKESKTQCLKLAF------------KGA------TEEPEVIP-DPAK- 744

  Fly   543 CTPRVCEGDEVLMING--------------------------------------RDVHGLRHEQV 569
                  :.|:|:.|.|                                      :|..|...:::
Zfish   745 ------QTDQVVKIAGISAAVLVFILLVLVAILLLKKRRSYYSYSYYLKLAKKRKDAIGNTRQEM 803

  Fly   570 VAMIRDCRH--------QASGELLLTVRPQRSAPLLLEEEPLYQ---YVPESDE-------IGSH 616
            ..|:.....        .|...:.:|.....:....|..|||..   .||.:||       ...:
Zfish   804 THMVNSMDRSYADQSTLHAEEPMTVTFMDSHNFSNRLPNEPLVPTAVLVPITDENHTAAAAAAEN 868

  Fly   617 SNLLD------------------------GDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLA 657
            |.|||                        .|.|...:|:..||   |.....:||..: :....:
Zfish   869 SRLLDIPRYHCEGTESPYQTGQLHPAIRVADLLQHINLMKTSD---SYGFKEEYESFF-EGQSAS 929

  Fly   658 ITEARKPANAPKNRYRDISPYDCTRVSL---VNSLTGDYINANYVNMEIPGGAV----------- 708
            ...|:|..|..||||.:|..||.:||.|   .:..:.|||||||:  ::.|.|.
Zfish   930 WDAAKKEQNRTKNRYGNIIAYDHSRVILQPMEDDPSSDYINANYI--DVSGDAASSSIGERVRNV 992

  Fly   709 ---------------NRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVT 758
                           :.|||||||:..|..|||||:.||.|..:||:|.::|.||.||::|||
Zfish   993 SPSLIWLYRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP-- 1055

  Fly   759 GEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDK--HEQRHIHHMQYLAWPDHCVPSDPNLFLE 821
             ::.::...|.|..:..:|  ...:|.|.|.|:.:  :|.|.:....:..||||.||......|.
Zfish  1056 -DDAEVYGDFKVTFVEVEP--LAEYVVRTFTLERRGFNEVREVKQFHFTGWPDHGVPYHATGLLS 1117

  Fly   822 FTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQ 886
            |..||:
Zfish  1118 FIRRVK----------------------------------------------------------- 1123

  Fly   887 CISAANP----PVIVHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQRACMVQNVSQ 947
               .:||    |::||||||.||||..|::|..|.:.|....|...:.|:.:|.:|..|||...|
Zfish  1124 ---MSNPPTAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQ 1185

  Fly   948 YRFVCE-----CIC-----------AAYMKISRSSAAIN 970
            |.|:.:     |:|           |||..:.|..:..|
Zfish  1186 YIFIHDAILEACLCGETAIPVCEFKAAYYDMIRIDSQSN 1224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	13/60 (22%)
		FA	333..369	CDD:285894	4/35 (11%)
		PDZ_signaling	502..589	CDD:238492	15/132 (11%)
		Y_phosphatase	666..955	CDD:278528	93/328 (28%)
		PTPc	668..955	CDD:238006	92/326 (28%)
ptprk	XP_021324239.1	MAM	30..191	CDD:214533
		IG_like	201..282	CDD:214653
		fn3	293..370	CDD:306538
		fn3	491..582	CDD:306538	25/122 (20%)
		PTPc	940..1195	CDD:238006	92/323 (28%)
		PTPc	1257..1495	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910