DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and EPB41L4B

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_011517092.1	Gene:	EPB41L4B / 54566	HGNCID:	19818	Length:	941	Species:	Homo sapiens

Alignment Length:	850	Identity:	218/850 - (25%)
Similarity:	319/850 - (37%)	Gaps:	226/850 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GGGPEL-----------ARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSE 71
            ||||.|           ...|.|   ..| .|..||....:..:.|.|||.:|.||:..:|:|.|
Human    62 GGGPLLTGGAAVHISAAGAAKAT---LYC-RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVE 122

  Fly    72 RDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQF 136
            .|||||.|... ..|..|:|..|..|||     :.......|.||||::.|:|:.|:||||||.|
Human   123 TDYFGLQFLDS-AQVAHWLDHAKPIKKQ-----MKIGPAYALHFRVKYYSSEPNNLREEFTRYLF 181

  Fly   137 YLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGEL 201
            .||::.:||.|||.|...|...||:..:|:|||:....||.|..:|..:.:.:||...|..:.:.
Human   182 VLQLRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQR 246

  Fly   202 HKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWS 266
            .|..||:.||.||.:||..||.||:||:|:|.....:|.|..||::..|:|:|:.:.::..|.|.
Human   247 WKECRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWP 311

  Fly   267 KMVKVSFKRKDFFIQLRREPS---ENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRP--HRL 326
            |:.|:.||:....:.:..:..   |...|.: |.:.|.:..|.|||..||||:||||:.|  .:.
Human   312 KITKMDFKKSKLTLVVVEDDDQGREQEHTFV-FRLDSARTCKHLWKCAVEHHAFFRLRTPGNSKS 375

  Fly   327 SRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQH 391
            :|...|.|||:|.:|||||.||...|:.|..  ..|.|.||||.                |.::|
Human   376 NRSDFIRLGSRFRFSGRTEYQATHGSRLRRT--STFERKPSKRY----------------PSRRH 422

  Fly   392 SGSESANSHNNGKPAGAGTILTITKTS-------------------RPHDNKVT-------SKEA 430
            |..:::|      |..|..:.:.|...                   .||...|:       ...:
Human   423 STFKASN------PVIAAQLCSKTNPEVHNYQPQYHPNIHPSQPRWHPHSPNVSYPLPSPVLSSS 481

  Fly   431 DSMP------------------------RKAWEQQSDEYDIQLDVGFIEQCTRRFESASPS---- 467
            |.:|                        .:...|....|.:.|.:...|...|...|:|.|
Human   482 DRLPFGIEENGGTPFLTAASGRHHHQHQHQHQHQHHSNYSLSLTLENKEGPLRSPNSSSKSLTKL 546

  Fly   468 ---------------------------PMPPAY---SSGQHSPI--------LLPTTIADAVGHQ 494
                                       |.||.:   :..:...:        |||:.:||.|
Human   547 SPGTPALFSEAAAHLKKLELETVKAAGPWPPLHININKAEEKKVSEKTLQTPLLPSPVADHV--- 608

  Fly   495 QPESGSDLITIRLQADEQGRYGFNVKGGVDLS-------------------LPVQVSKVVPHTPA 540
                  ....::.|.:...|  .|::||.:.|                   :|::|....|....
Human   609 ------KCNILKAQLENASR--VNIQGGKEESPFVNINKKSSLQDASVRSPIPIRVETAQPAVEK 665

  Fly   541 DRC-TPRVCEGDEVLMINGRDVHGLRHE--QVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEP 602
            ... .|||.:.......|..|...|..:  :.|.:........:     |...|.|.||   ..|
Human   666 PEIKPPRVRKLTRQYSFNRSDEDDLPPDLAEAVGVTTSTTTNTT-----TAATQVSVPL---PSP 722

  Fly   603 LYQYV--PESDE--------------IGSHSNLLDGDAL--FTQSLLL----------------- 632
            ..|.|  |...|              .|....|..||.|  ||::..|
Human   723 KVQNVSSPHKSEGKGLLSPGAKSPSDRGGAFTLEPGDLLMDFTEATPLHWLKATPQLSRPLAPPA 787

  Fly   633 ----LSDGLASG--ALLAQYELMYRKNPDLAITEARKPANAP-KNRYRDISPYDCTRVSLVNSLT 690
                |..||..|  ||:...:.....||..|.:....|.:.| |.....:..|...:..|:.:..
Human   788 IFHPLHTGLPLGMAALVGLLQAEPASNPHCAHSRCSPPLSLPMKEETTGVCMYPPIKTRLIKTFP 852

  Fly   691 GDYIN 695
            .|.:|
Human   853 VDTMN 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	80/196 (41%)
		FERM_N	38..102	CDD:286467	26/63 (41%)
		FERM_M	125..232	CDD:278785	46/106 (43%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	31/96 (32%)
		FA	333..369	CDD:285894	17/35 (49%)
		PDZ_signaling	502..589	CDD:238492	17/108 (16%)
		Y_phosphatase	666..955	CDD:278528	5/30 (17%)
		PTPc	668..955	CDD:238006	5/28 (18%)
EPB41L4B	XP_011517092.1	B41	87..277	CDD:214604	80/196 (41%)
		FERM_N	89..151	CDD:286467	26/67 (39%)
		FERM_M	170..277	CDD:278785	46/106 (43%)
		FERM_C_NBL4_NBL5	273..366	CDD:270007	29/93 (31%)
		FA	379..419	CDD:285894	20/57 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910