DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Ptpn3

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_006538160.1	Gene:	Ptpn3 / 545622	MGIID:	105307	Length:	935	Species:	Mus musculus

Alignment Length:	1009	Identity:	362/1009 - (35%)
Similarity:	532/1009 - (52%)	Gaps:	172/1009 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RLNNLTRTFRLRGGGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELS 70
            |:|| |||..|    |:    :||.....| ::.|||.:..||::.|:..|..|||..:.:|.::
Mouse    33 RINN-TRTSEL----PK----EKTRSEVIC-SIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVT 87

  Fly    71 ERDYFGLLFPQKPGDVVRWVDAQKQFKKQ------CSSVSLDNDAVPLLEFRVKFFVSDPSRLQE 129
            |::||||.....|.|..||::|.|..:||      |:           |.|||::|:.||:.||:
Mouse    88 EKEYFGLQHGDDPVDSPRWLEASKPLRKQLKGGFPCT-----------LHFRVRYFIPDPNTLQQ 141

  Fly   130 EFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEA 194
            |.||:.::||:|.::..|:|.|..|:..:||||.|||..||||:..|.||||:..|.:.||..:.
Mouse   142 EQTRHLYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHFGDFNSSIHHPGYLADSQFIPDQNDDF 206

  Fly   195 ERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLR 259
            ..||..||:.|.|...::||..|:..|:.|:.||::||...|.:..:|.:|:::.|:.|::..:.
Mouse   207 LSKVESLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVYRKYIC 271

  Fly   260 VNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR-- 322
            .:.:.|..::|:|||||.|||..|::.:|:.:.::.|.|.:::..|.||||||||||||:.|:
Mouse   272 TSFYPWVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLL 336

  Fly   323 PHR---LSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSG 384
            |..   ||::.  :|||      |...::|.....: ::....|.:|..|...:...:.|.....
Mouse   337 PQEKNVLSQYW--TLGS------RNPKKSVNNQYCK-KVIGGMVWNPVMRRSLSVERLETKSLPS 392

  Fly   385 GTPMQQHSGSESANSHNNGKPAG------AGTILTITKTS---RPHDNKVTSKEADSMPRKAWEQ 440
            .:|....:.......|...||..      |..:..||:|.   ..:...::.|::||   :..:.
Mouse   393 RSPPITPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGPLSPKDSDS---EVSQN 454

  Fly   441 QSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVG-------HQQPES 498
            .|...:...:....:.|..:..|:|.||...|  .|..||        |.|.       |:..:.
Mouse   455 HSPHRESLSENNPAQSCLTQKSSSSVSPSSNA--PGSCSP--------DGVDQRFLEDYHKVTKG 509

  Fly   499 G------------SD-----LITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPR 546
            |            ||     |:.||:..||:||:|||:|||||..:|:.||::.|.:|||.|.|:
Mouse   510 GFVEDASQYYCDKSDDGDGYLVLIRITPDEEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMPK 574

  Fly   547 VCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQ--RSAPLLLEEEPLYQYVPE 609
            :.|||::::|||||:....|:|||..|:..|...|.||.|.:|.:  ||...:..|:.|.|..||
Mouse   575 LNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFPE 639

  Fly   610 S-----DEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPK 669
            :     .|        .||:| ..|:.||..||.||.:|.|:|.:|||.|.||::.|:.|.|..|
Mouse   640 AMFPACPE--------GGDSL-EGSMELLKKGLESGTVLIQFEQLYRKKPGLAVSFAKLPQNLDK 695

  Fly   670 NRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIP-GGAVNRYIATQGPLASTTTDFWRMVQQES 733
            |||:|:.|||.|||.|..:  .|||||:|||||:| ...||:||||||||.:|...||::|..:.
Mouse   696 NRYKDVLPYDTTRVLLQGN--EDYINASYVNMEMPAANLVNKYIATQGPLPNTCAQFWQVVWDQK 758

  Fly   734 SHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEG-FSVRCLSEKPDETGSFVFREFVLKDKH--E 795
            ..|:|||||:.|.||.|||||||...:.:.  .| |.::|.:|  |.|.::|.||.::.:..  |
Mouse   759 LSLVVMLTTLTERGRTKCHQYWPDPPDIMD--HGIFHIQCQTE--DCTIAYVSREMLVTNTETGE 819

  Fly   796 QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGGL 860
            :..:.|:||:|||||.||.|.:.||||.:.||:.|                 :|.:
Mouse   820 EHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLR-----------------VDGE--------- 858

  Fly   861 MRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREPV 925
                                             |.:|||||||||||||:.|:||:.|:|...||
Mouse   859 ---------------------------------PALVHCSAGIGRTGVLVTMETAMCLIERNLPV 890

  Fly   926 YPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY 959
            |||||||.||||||.|||..|||:||||.|...|
Mouse   891 YPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	77/202 (38%)
		FERM_N	38..102	CDD:286467	25/69 (36%)
		FERM_M	125..232	CDD:278785	44/106 (42%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	36/93 (39%)
		FA	333..369	CDD:285894	7/35 (20%)
		PDZ_signaling	502..589	CDD:238492	42/86 (49%)
		Y_phosphatase	666..955	CDD:278528	127/292 (43%)
		PTPc	668..955	CDD:238006	126/290 (43%)
Ptpn3	XP_006538160.1	B41	53..244	CDD:214604	77/202 (38%)
		FERM_C_PTPN4_PTPN3_like	238..331	CDD:270010	35/92 (38%)
		PDZ_signaling	530..617	CDD:238492	42/86 (49%)
		PTPc-N3	653..926	CDD:350448	147/337 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3181
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	644	1.000	Inparanoid score	I801
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49050
OrthoDB	1	1.010	-	-		D59173at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44231
orthoMCL	1	0.900	-	-		OOG6_104957
Panther	1	1.100	-	-	LDO	PTHR45706
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1974
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.840