DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Epb41l4b

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_011248370.1	Gene:	Epb41l4b / 54357	MGIID:	1859149	Length:	902	Species:	Mus musculus

Alignment Length:	556	Identity:	171/556 - (30%)
Similarity:	247/556 - (44%)	Gaps:	103/556 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 GGGP--------ELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDY 74
            ||||        .::..........| .|..||....:..:.|.|||.:|.||:..:|:|.|.||
Mouse    62 GGGPLLTGGAAVHISASGAAKATLYC-RVFLLDGTEVSVDLPKHAKGQDLFDQIVYHLDLVETDY 125

  Fly    75 FGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQ 139
            |||.|... ..|..|:|..|..|||     :.......|.||||::.|:|:.|:||||||.|.||
Mouse   126 FGLQFLDS-AQVTHWLDHAKPIKKQ-----MKVGPAYALHFRVKYYSSEPNNLREEFTRYLFVLQ 184

  Fly   140 IKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKL 204
            ::.:||.|||.|...|...||:..:|:|||:....||.|..:|..:.:.:||...|..:.:..|.
Mouse   185 LRHDILSGKLKCPYETAVELAALCLQAELGECELPEHTPELVSEFRFIPNQTEAMEFDIFQRWKE 249

  Fly   205 HRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMV 269
            :||:.||.||.:||..||.||:||:|:|.....:|.|..||::..|:|:|:.:.::..|.|.|:.
Mouse   250 YRGKSPAQAELSYLNKAKWLEMYGVDMHVVRGRDGCEYSLGLTPTGILIFEGANKIGLFFWPKIT 314

  Fly   270 KVSFKRKDFFIQLRREPS---ENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRP--HRLSRF 329
            |:.||:....:.:..:..   |...|.: |.:.|.:..|.|||..||||:||||:.|  .:.:|.
Mouse   315 KMDFKKSKLTLVVVEDDDQGREQEHTFV-FRLDSARTCKHLWKCAVEHHAFFRLRTPSNSKSARS 378

  Fly   330 LNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGS 394
            ..|.|||:|.:|||||.||...|:.|..  ..|.|.||||.                |.::||..
Mouse   379 DFIRLGSRFRFSGRTEYQATHGSRLRRT--STFERKPSKRY----------------PSRRHSTF 425

  Fly   395 ESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEAD---SMPRKAWEQQSDEYDIQLDVGFIEQ 456
            :::|      |..|..:  .:|.:....|.......|   |.||  |...|......|....:..
Mouse   426 KASN------PVIAAQL--CSKANPEVHNYQPQYHPDVHPSQPR--WRPHSPNVSYPLPSPALSP 480

  Fly   457 CTR---RFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFN 518
            ..|   ..|....:|..|. :||:|.             ||.            |......||
Mouse   481 TERLPFSLEENGGTPFAPK-TSGRHH-------------HQH------------QHQHHSNYG-- 517

  Fly   519 VKGGVDLSLPVQ--------------VSKVVPHTPA 540
                  |||.::              ::|:.|.|||
Mouse   518 ------LSLTLENKEAPLRSPNASKALTKLSPGTPA 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	80/196 (41%)
		FERM_N	38..102	CDD:286467	26/63 (41%)
		FERM_M	125..232	CDD:278785	46/106 (43%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	31/96 (32%)
		FA	333..369	CDD:285894	17/35 (49%)
		PDZ_signaling	502..589	CDD:238492	11/53 (21%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Epb41l4b	XP_011248370.1	B41	87..277	CDD:214604	80/196 (41%)
		FERM_C_NBL4_NBL5	273..366	CDD:270007	29/93 (31%)
		FA	379..419	CDD:370090	20/57 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910