DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and SNTG1

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001274742.1	Gene:	SNTG1 / 54212	HGNCID:	13740	Length:	517	Species:	Homo sapiens

Alignment Length:	364	Identity:	89/364 - (24%)
Similarity:	142/364 - (39%)	Gaps:	102/364 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 SGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVH 562
            ||...:|||.|.  .|.:|.::|||.:.::||.|||:.....|: .:..:..||.:|.|||.:|.
Human    53 SGERTVTIRRQT--VGGFGLSIKGGAEHNIPVVVSKISKEQRAE-LSGLLFIGDAILQINGINVR 114

  Fly   563 GLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQ---YVPESDEIGSHSNLLDG-- 622
            ..|||:||.::|:    |..|:.|||...:.||..| :.||.:   ..|.....|:.|.|.|.
Human   115 KCRHEEVVQVLRN----AGEEVTLTVSFLKRAPAFL-KLPLNEDCACAPSDQSSGTSSPLCDSGL 174

  Fly   623 ---------DALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAP------KNRY 672
                     |.|...| ...|.||       ::|..:.....:.:..:|.....|      :|.:
Human   175 HLNYHPNNTDTLSCSS-WPTSPGL-------RWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAF 231

  Fly   673 RDI-------------SPYDC--------TRVSLVNSLTGDYINANY-VNMEI------------ 703
            :.|             |..||        |.:|.:.......||.|: ||.:|
Human   232 QVIAVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQD 296

  Fly   704 --------------PGGAVNRYIATQGPLASTTTDFWRMVQQESSHLLVMLTTVMESG----RQK 750
                          .|..:.:::|.  |:  ||.| |...::..|...:|...:.:|.    |::
Human   297 PLQDRVYSPTFLALRGSCLYKFLAP--PV--TTWD-WTRAEKTFSVYEIMCKILKDSDLLDRRKQ 356

  Fly   751 CHQYWPVTGEELQLAEGFSVRCLS-----EKPDETGSFV 784
            |......:||:|.    |||...|     |:..:|.:|:
Human   357 CFTVQSESGEDLY----FSVELESDLAQWERAFQTATFL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	32/86 (37%)
		Y_phosphatase	666..955	CDD:278528	36/182 (20%)
		PTPc	668..955	CDD:238006	36/180 (20%)
SNTG1	NP_001274742.1	PDZ_signaling	55..136	CDD:238492	31/87 (36%)
		PH	191..259	CDD:214574	11/74 (15%)
		PH	284..389	CDD:214574	22/113 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910