DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Frmpd2

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_038950838.1	Gene:	Frmpd2 / 498583	RGDID:	1565652	Length:	1352	Species:	Rattus norvegicus

Alignment Length:	775	Identity:	169/775 - (21%)
Similarity:	279/775 - (36%)	Gaps:	220/775 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 QCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVD------- 91
            ||:.|          :.:..:....:.:.|..:..|.|..||||.:.:  |:...:::
  Rat   351 QCLEV----------KCDVESTAGAVFNAVMSFANLGETTYFGLAYVK--GEEFFFLEPNTRLCK 403

  Fly    92 -AQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNT 155
             |.:.:::|....|:|   ...|..|:|||||....|:...||:|||||::::||..:|.|:..|
  Rat   404 VAPEGWREQQPKSSVD---TLTLFLRIKFFVSHYGLLRHSLTRHQFYLQLRKDILEERLYCNDET 465

  Fly   156 QCLLASYTVQSELGD-----------FNALEHQPGYLSGMQLLCDQTT--EAERKVGELHKLHRG 207
            ...|....:|:|.|.           |...::.|.      .|.::.|  ..:.:|.|:|:|...
  Rat   466 LLQLGVLALQAEFGSYPKEQVEGETYFQIQDYIPA------RLIERMTAIRVQVEVSEMHRLSPA 524

  Fly   208 QLPADAEYNYLEHAKRLELYGIDLHRATDSNGKE---LQLGVSAVGLLVFQ--HSLRVNTFS--W 265
            ....|||..:||..::|..||:.:||.:.:..::   :.||:...|::|::  .|.|..||.  |
  Rat   525 PQGEDAELEFLEVVQQLPEYGVLVHRVSPAKKRQEGGMALGICTKGIIVYEVKGSRRTTTFQFPW 589

  Fly   266 SKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSF---FRLKRPHRL- 326
            .:...:|..|:...:     .|........|...|.|..|.|...|...|.|   ..|::|..|
  Rat   590 RETGMISTHRRKLTV-----TSSTTGKKYTFVTDSAKTCKYLLGLCSSQHWFNAHMGLEQPPHLL 649

  Fly   327 ---SRFLNI-SLGSKFYYSGR--TELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGG 385
               .:|..| ||.|.......  |.:|.:..|:....:         .||..|.||      ..|
  Rat   650 TGQDKFAQIASLNSAHQTQANPLTWIQKLSCSENELCV---------PRLQNATGG------QLG 699

  Fly   386 TPMQQHSGS-ESANSHNNGKP-AGAGTILTITKTSRP---------HDNKVTSKEADSMPRKAW- 438
            |.|:...|| |.....|...| .|...:.:|....||         |.....|:::   .||.:
  Rat   700 TAMENMQGSKEPEMGRNRSSPYTGGEQLHSIGLNQRPTHTLFGTAGHSTCAGSQKS---KRKGFM 761

  Fly   439 -EQQSD------EYDIQLDVGFI-------EQCTRRFESASPSPMPPA----------------- 472
             |...|      :.|..|..||:       ||.......:|..|..||
  Rat   762 DEPNGDIMCVMLKRDPLLGFGFVIYEGEDKEQSKTGIFISSLIPGGPAERAKKIKPGGKILALNH 826

  Fly   473 --------------------------------------------YSSGQHSPILL---------- 483
                                                        .|||.....:|
  Rat   827 ISMEGFTFNMAVKMIQNSPDDIELIISQPKGVCGDIPSEDKNSTASSGTFCTDILSNRCRGQQSA 891

  Fly   484 -----------PTTIADAVGH--QQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLP---VQVS 532
                       |.|:....|.  ..|....::..:.| ..|.|..||:|.||::.|:|   :.|.
  Rat   892 HTQDQDRNARGPETVQQGAGSCPPSPLDAGEIYFVEL-VKEDGTLGFSVTGGINTSVPHGGIYVK 955

  Fly   533 KVVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLL 597
            .::|..||.: ..::.:||.:|.::|..:.||.|:|.|..::.....|  :|:|..|..|:||
  Rat   956 SIIPGGPAAK-EGQILQGDRLLQVDGVSLCGLTHKQAVQCLKGPGQVA--QLVLERRGPRAAP-- 1015

  Fly   598 LEEEPLYQYVPESD----EIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKN 653
                    ..|.:|    |:....:|:........|.:.::||       .::|:..:||
  Rat  1016 --------QCPSADDRMGEVHMAVSLVTAKPGRPASRVSVTDG-------PKFEVKLKKN 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	54/217 (25%)
		FERM_N	38..102	CDD:286467	11/71 (15%)
		FERM_M	125..232	CDD:278785	33/119 (28%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	24/103 (23%)
		FA	333..369	CDD:285894	6/37 (16%)
		PDZ_signaling	502..589	CDD:238492	26/89 (29%)
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
Frmpd2	XP_038950838.1	PKc_like	15..197	CDD:419665
		Ubiquitin_like_fold	340..433	CDD:421700	21/96 (22%)
		B41	343..549	CDD:214604	55/218 (25%)
		PH-like	545..645	CDD:418428	24/104 (23%)
		PDZ_signaling	768..852	CDD:238492	10/83 (12%)
		PDZ	922..1010	CDD:214570	26/91 (29%)
		PDZ	1053..1142	CDD:214570	3/8 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910