DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and csw

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_477131.1	Gene:	csw / 45278	FlyBaseID:	FBgn0000382	Length:	945	Species:	Drosophila melanogaster

Alignment Length:	829	Identity:	179/829 - (21%)
Similarity:	272/829 - (32%)	Gaps:	320/829 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   312 VEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESK---QRGRIHKVFVRSPSKRLLGA 373
            :.:::.:..:|.....|.:....|||    ||...:..:..|   .:||  |..|..|::
  Fly    41 LNNNNAYNNQRNFEYERAIQAHYGSK----GRRSEERERSGKFKASKGR--KAKVTPPTE----- 94

  Fly   374 AGGVGTSGSSGGTPMQQHSGSESANSHN------NGKPAGAGTILTITKTSRPHDNKVTSKE--A 430
                        ||..|....::..:|:      .|...||       ...|..||::..:.  .
  Fly    95 ------------TPEAQEPACKNCMTHDELAQIIKGVAKGA-------DAQRNRDNRLQRRRRPL 140

  Fly   431 DSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPM---PPAYSSGQHSPILLPTTIADAVG 492
            .:.|..|....:.              |......:|||.   |...:|...:|...|.....|
  Fly   141 SAQPSAAASASTS--------------TESLHRLTPSPQASYPATPTSWTATPPQFPAAFGGA-- 189

  Fly   493 HQQPESGSD-----LITIRLQADEQGRYGFNVKG----------GVDLSLPVQVSKVVPHTPADR 542
                 |.|:     |.|:|:|......:..|:.|          |.:.|..|:.|:..|
  Fly   190 -----SCSNSTLSLLATMRVQLHGYTWFHGNLSGKEAEKLILERGKNGSFLVRESQSKP------ 243

  Fly   543 CTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYV 607
                   ||.||.:...|    :...|:...:|.::...|        ..|...|.|....|:..
  Fly   244 -------GDFVLSVRTDD----KVTHVMIRWQDKKYDVGG--------GESFGTLSELIDHYKRN 289

  Fly   608 PESDEIGSHSNL---LDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPD-LAITEARKPANAP 668
            |..:..|:..:|   .:...:....:....:.|..|....::|.:.:.:.| .:..|..|..|..
  Fly   290 PMVETCGTVVHLRQPFNATRITAAGINARVEQLVKGGFWEEFESLQQDSRDTFSRNEGYKQENRL 354

  Fly   669 KNRYRDISPYDCTRVSLV---NSLTG-DYINANYV------------------NMEIP------- 704
            |||||:|.|||.|||.|:   :|:.| :||||||:                  |..:|
  Fly   355 KNRYRNILPYDHTRVKLLDVEHSVAGAEYINANYIRLPTDGDLYNMSSSSESLNSSVPSCPACTA 419

  Fly   705 ----------------------------------------------------------------- 704

  Fly   420 AQTQRNCSNCQLQNKTCVQCAVKSAILPYSNCATCSRKSDSLSKHKRSESSASSSPSSGSGSGPG 484

  Fly   705 --------------------------------------GGAVN----------------RYIATQ 715
                                                  .|||:                .|||||
  Fly   485 SSGTSGVSSVNGPGTPTNLTSGTAGCLVGLLKRHSNDSSGAVSISMAEREREREREMFKTYIATQ 549

  Fly   716 GPL----ASTTTDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEK 776
            |.|    .:|.||||.||.||::.::||.|...|.|::||.:|||..|...|.... .::|:||
  Fly   550 GCLLTQQVNTVTDFWNMVWQENTRVIVMTTKEYERGKEKCARYWPDEGRSEQFGHA-RIQCVSE- 612

  Fly   777 PDETGSFVFREFVLKDKHE-QRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEE 840
             :.|..:..|||::..:.: .|.|.|..:..||||.||:||...|.|            ||::
  Fly   613 -NSTSDYTLREFLVSWRDQPARRIFHYHFQVWPDHGVPADPGCVLNF------------LQDV-- 662

  Fly   841 SLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGR 905
            :.:|..|    |.|.|..|                                  |:.|||||||||
  Fly   663 NTRQSHL----AQAGEKPG----------------------------------PICVHCSAGIGR 689

  Fly   906 TGVLILMDTALALMEAREPVYPLDIVRT---MRDQRACMVQNVSQYRFV 951
            ||..|::|..|..:........:||.||   :|.||:.:||..:||:||
  Fly   690 TGTFIVIDMILDQIVRNGLDTEIDIQRTIQMVRSQRSGLVQTEAQYKFV 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	0/7 (0%)
		FA	333..369	CDD:285894	11/38 (29%)
		PDZ_signaling	502..589	CDD:238492	19/96 (20%)
		Y_phosphatase	666..955	CDD:278528	111/442 (25%)
		PTPc	668..955	CDD:238006	110/440 (25%)
csw	NP_477131.1	SH2_C-SH2_SHP_like	211..307	CDD:198185	22/120 (18%)
		PTPc	326..744	CDD:214550	115/468 (25%)
		PTPc	543..743	CDD:238006	84/251 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443561
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930