DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and epb41l3b

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_999977.1	Gene:	epb41l3b / 407981	ZFINID:	ZDB-GENE-021106-1	Length:	838	Species:	Danio rerio

Alignment Length:	982	Identity:	269/982 - (27%)
Similarity:	399/982 - (40%)	Gaps:	281/982 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RFRLNNLTRTFRLRGGGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLE 68
            |...:.|.|.:|||              ..:| .:..||...:|..:||||:|..|.|:|..:|.
Zfish    51 RLSWSALGRNYRLR--------------IMEC-KITLLDGTDYTCTVEKRARGQVLFDKVCDHLN 100

  Fly    69 LSERDYFGLLF----PQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQE 129
            |.|:||||:.:    .||     .|:||.|:.|||.|:....      ..|.|||:..||::|.|
Zfish   101 LLEKDYFGITYSDTESQK-----NWLDASKEIKKQISTSPWS------FAFNVKFYPPDPAQLSE 154

  Fly   130 EFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEA 194
            :.|||...||::.:::.|:||||.:|..:|.|||:||||||.::.......||.::...:|:.|.
Zfish   155 DITRYFLCLQLRDDVVSGRLPCSFSTHAVLGSYTLQSELGDCDSELQNSSALSDLRFAPNQSKEL 219

  Fly   195 ERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRA--------------TDSNGKELQLG 245
            :.||.|||:.:||..||:|:..:||:||:|.:||:|||||              .||.|.|:.||
Zfish   220 QDKVLELHRAYRGMTPAEADMLFLENAKKLSMYGVDLHRAKLLTRLEWLAVLQEEDSEGVEIMLG 284

  Fly   246 VSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKS 310
            |.:.||||::..||:|.|:|.|::|:|:||.:|:|::|....|.:::.:||.:.:||.||.|||.
Zfish   285 VCSSGLLVYRDKLRINRFAWPKILKISYKRNNFYIKVRPGELEQFESTIGFKLPNHKAAKRLWKV 349

  Fly   311 CVEHHSFFRLKRPHR-LSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAA 374
            |||||:||||..|.. ..|||  :|||||.|||||:.|:.:.|.|..|....|.|:.|:|..
Zfish   350 CVEHHTFFRLVSPEAPPKRFL--TLGSKFRYSGRTQAQSRRASSQIARAAPHFQRTTSRRHT--- 409

  Fly   375 GGVGTSGSSGGTPMQQHSGSESANSHNNGKPAGAGTILTITKT----------SRPHDNKVTSKE 429
                .:.|...||...:...|..||    |||.....|...:|          |...:||.|::|
Zfish   410 ----VTASMDNTPASVNHEEELKNS----KPAAVPDELITAETPEKKSEEKINSTEEENKTTAEE 466

  Fly   430 ADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQ 494
            .        ||.|.          :.:|              .|||             ||
Zfish   467 P--------EQASP----------VTKC--------------VYSS-------------DA---- 482

  Fly   495 QPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTPRVCEGDEVLMIN-- 557
                   |::                   |||||   |..|..|.. ||..|||.......::
Zfish   483 -------LVS-------------------DLSLP---SSPVSSTRV-RCRRRVCVRQRAASVSPA 517

  Fly   558 ----GRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLEEEPLYQYVPESDEIGSHSN 618
                |......:.|:..|::.:      ..|||:.|.||   |......|:.:   |..:...|.
Zfish   518 KSGAGERRRRAQEERRAALLEE------RALLLSARKQR---LSRRRGTLFSF---SLHLPDVSA 570

  Fly   619 LLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAPKNRYRDISPYDCTRV 683
            |||.|.                         |...|||  ||.|   ..|::..|      |..|
Zfish   571 LLDDDG-------------------------YLSFPDL--TELR---FLPQSLQR------CVPV 599

  Fly   684 ---SLVNSLTGDYINANYVNMEIPGGAVNRYIATQG-PLASTTTDFWRMVQQESSHLLVMLTTVM 744
               ||:......:......:..:|      |..|.. |||....    .::..::.|...||..:
Zfish   600 RSPSLIPCFLFIFFFLLSTSFSVP------YALTLSFPLALCLC----YLEPRAAKLSSELTQSL 654

  Fly   745 ESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPD 809
            :...:         .||..          |::.|..|..........|..:..|....:
Zfish   655 QDSSE---------DEETD----------SDQTDLAGDDDDTSLTESDFEDDAHTRTQE------ 694

  Fly   810 HCVPSDPNLFLEFTERVRA------ARNRTL---LQEIEESLKQVRLM------------DADAD 853
                         :|.|:|      .:...|   ||:.||::|.|.::            :|||:
Zfish   695 -------------SEEVKADAEDAPVKTEHLTDGLQQCEEAVKDVPVVHTETKTITYESSEADAN 746

  Fly   854 ADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAA--NPPVIVHCSAGIGRTGVLILMDTAL 916
            .|.|.|:....:...|...:....|.::.:|...||..  ...:::...|.|.....|     |.
Zfish   747 GDSNPGVFMSAQTITSEKNSTTTTTHITKTVKDGISETRIEKRIVISGDADIDHDQAL-----AQ 806

  Fly   917 ALMEARE 923
            |:.||:|
Zfish   807 AIKEAKE 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	80/200 (40%)
		FERM_N	38..102	CDD:286467	27/67 (40%)
		FERM_M	125..232	CDD:278785	45/106 (42%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	48/107 (45%)
		FA	333..369	CDD:285894	17/35 (49%)
		PDZ_signaling	502..589	CDD:238492	20/92 (22%)
		Y_phosphatase	666..955	CDD:278528	51/285 (18%)
		PTPc	668..955	CDD:238006	51/283 (18%)
epb41l3b	NP_999977.1	B41	67..257	CDD:214604	80/201 (40%)
		FERM_N	70..132	CDD:286467	27/66 (41%)
		FERM_M	152..257	CDD:278785	45/104 (43%)
		FERM_C_4_1_family	252..359	CDD:270005	48/106 (45%)
		FA	368..408	CDD:285894	20/41 (49%)
		Upf2	656..>704	CDD:281974	10/85 (12%)
		4_1_CTD	725..830	CDD:283537	20/94 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910