DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and ptpn3

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_687930.5	Gene:	ptpn3 / 407635	ZFINID:	ZDB-GENE-030131-2934	Length:	839	Species:	Danio rerio

Alignment Length:	952	Identity:	326/952 - (34%)
Similarity:	480/952 - (50%)	Gaps:	147/952 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKP 83
            |..:|::....|:......|||.|..|..|.:.|...|..|.|...::|.:.|:.||.:...:..
Zfish    16 GRADLSKHTHMPRSGLLCLVLFPDGTTQNFTVNKHDAGHLLFDLACEHLNIVEKQYFSMQISEDT 80

  Fly    84 GDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGK 148
            ....||:|..|.||||     |.......|.|||:||:|||:.||.|.||:.::|||:::|..|:
Zfish    81 SSSPRWLDPNKPFKKQ-----LKGSPPFFLMFRVRFFISDPNSLQHEQTRHFYFLQIRKDICEGR 140

  Fly   149 LPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADA 213
            |.|..::..:||||:|||||||:|. |...||||....:.:|..|...||..||..|:|...:||
Zfish   141 LKCPLSSAVVLASYSVQSELGDYNP-ETPTGYLSKTHFIPEQDQEFLLKVESLHPQHKGLSQSDA 204

  Fly   214 EYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDF 278
            |..||..|:.|:|||::||.|.|::...:.:|:::.|:.:|.|.:..:.|.|..::|:|||||.|
Zfish   205 ELCYLNTARTLDLYGVELHHAQDASNPAVWVGITSGGVALFCHLICSSFFPWINIIKISFKRKRF 269

  Fly   279 FIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGR 343
            |:.|||:..|....::...|.:.:..|.||:|||:||:|:..|..|..|:..:|.|..|..  |.
Zfish   270 FVHLRRKHGELGHHVVSLSMPNSRACKNLWRSCVDHHTFYNRKPSHSASKLSSIPLYRKLV--GE 332

  Fly   344 TELQAVQESKQRGRIHKVFVRS-PSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNGKPAG 407
            ..|..:..|..   :.::..:| ||:             |...||  ........:...|.:|:.
Zfish   333 QMLNPMVRSSS---VEQLETKSLPSR-------------SPPNTP--NWRSPRVRHDFRNPRPSS 379

  Fly   408 AGTILT-ITKTSRPHDNKVTSKEADSMPRK--AWEQQSDEYDIQLDVGFIEQCTRRFESASPSPM 469
            ...:.. ::..:...|...|.::.....|:  :| ...|:..|:.|
Zfish   380 VDNLTNEMSYVTESEDVFYTYRKPQEEERRSGSW-SHGDDITIEED------------------- 424

  Fly   470 PPAYSSGQHSPILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKV 534
                  ..|            |..:...:..||:.:|:..|:.|::|||||||||..:|:.:|.|
Zfish   425 ------DLH------------VWDKSVTADGDLLLVRISPDQDGKFGFNVKGGVDQKMPLAISHV 471

  Fly   535 VPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLLLE 599
            ...:||.||.|.:.|||:||:|||||:....|:|||..|:..|...|.||.|.||.:   .:.|.
Zfish   472 NLASPAGRCVPPLMEGDQVLLINGRDISEHTHQQVVMFIKASRESHSKELALLVRRK---GVSLR 533

  Fly   600 EEPLYQY---VP-ESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITE 660
            .||..|.   :| |...:.:|.:   |:.| .:|:..|..||.:|.||..:|.:|||...:.::.
Zfish   534 VEPTLQLGLTLPGEISPLSTHPS---GETL-EESMARLEKGLVTGTLLLHFEKLYRKKEGMLMSC 594

  Fly   661 ARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPGGAVNRYIATQGPLASTTTDF 725
            |::..|..||||:|:.|||.|||.|... ..|||||::|..| |.|.|.:|||.||||..|.|.|
Zfish   595 AKQSENMDKNRYKDVLPYDITRVVLQEE-GDDYINASHVKTE-PAGCVLQYIAAQGPLPHTCTHF 657

  Fly   726 WRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGF-SVRCLSEKPDETGSFVFREFV 789
            ||.|.::..::::||||:.|.||.|||||||...|....  |: .|.|.||:.:.  ::|.|:..
Zfish   658 WRSVWEQDVNVIIMLTTLTERGRTKCHQYWPHPPEVRDY--GYLQVCCHSEECNL--AYVTRQLT 718

  Fly   790 LKDKH--EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADA 852
            |.:..  :||.|.|:||:|||||.||.|.:.||:|.:.||:.|        :||:
Zfish   719 LTNTQSGQQRSITHLQYVAWPDHGVPEDSSDFLDFVKSVRSMR--------QESV---------- 765

  Fly   853 DADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALA 917
                                                     |::||||||||||||||.|:||:.
Zfish   766 -----------------------------------------PLMVHCSAGIGRTGVLITMETAMT 789

  Fly   918 LMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY 959
            |||..:|||||:::..||:|||.:||...|:.||||.|...|
Zfish   790 LMEKEKPVYPLEVITLMREQRAMLVQTSCQFTFVCEAILRVY 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	79/196 (40%)
		FERM_N	38..102	CDD:286467	22/63 (35%)
		FERM_M	125..232	CDD:278785	47/106 (44%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	35/93 (38%)
		FA	333..369	CDD:285894	8/36 (22%)
		PDZ_signaling	502..589	CDD:238492	41/86 (48%)
		Y_phosphatase	666..955	CDD:278528	119/291 (41%)
		PTPc	668..955	CDD:238006	118/289 (41%)
ptpn3	XP_687930.5	B41	33..223	CDD:214604	79/195 (41%)
		FERM_N	35..98	CDD:286467	22/67 (33%)
		FERM_M	117..223	CDD:278785	47/106 (44%)
		PH-like	217..309	CDD:302622	34/91 (37%)
		PDZ_signaling	439..526	CDD:238492	41/86 (48%)
		PTPc	579..829	CDD:214550	125/314 (40%)
		PTPc	602..828	CDD:238006	118/290 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2756
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	661	1.000	Inparanoid score	I740
OMA	1	1.010	-	-		QHG49050
OrthoDB	1	1.010	-	-		D59173at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm24313
orthoMCL	1	0.900	-	-		OOG6_104957
Panther	1	1.100	-	-	LDO	PTHR45706
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1974
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.840