DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and ptpn4b

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_005174003.1	Gene:	ptpn4b / 407634	ZFINID:	ZDB-GENE-030131-6259	Length:	935	Species:	Danio rerio

Alignment Length:	1019	Identity:	427/1019 - (41%)
Similarity:	565/1019 - (55%)	Gaps:	171/1019 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LTRTFRLRG------GGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLE 68
            :|..|||..      |..|.||:::..| .:| .||.||:...|||:.|:.:|..|||.|:::||
Zfish     1 MTARFRLPAGRSYDVGALEEARERQHAQ-VEC-NVLLLDNTVQTFRVNKQDQGQILLDVVYKHLE 63

  Fly    69 LSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTR 133
            |:|||||||.......|..||:|..|..:||....|..|     |.|||||||.||.:||||:||
Zfish    64 LTERDYFGLQLADDTSDTQRWLDPNKPVRKQLKRPSPHN-----LRFRVKFFVGDPGKLQEEYTR 123

  Fly   134 YQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKV 198
            |.::||:|::||.|:|||..||..|||||.||:||||::..||..||||....:.:...:.|::|
Zfish   124 YLYFLQLKQDILSGRLPCPQNTAVLLASYAVQAELGDYSHSEHLSGYLSEYSFIPNPPQDFEKEV 188

  Fly   199 GELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTF 263
            .:||:.|.|..||.:|:|||..|:.|||||::||.|.|....|:.:||.:.|:.|::..:|||.|
Zfish   189 AKLHQEHNGLTPAQSEFNYLNAARTLELYGVELHYARDHCNTEIYVGVLSAGISVYKDRVRVNHF 253

  Fly   264 SWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSR 328
            .|.|:||:|||.|.||||||:|.:|..::||||.|.:::..|.|||||||:|:||||:||....|
Zfish   254 PWFKIVKISFKSKQFFIQLRKELTECRESLLGFNMMNYRACKNLWKSCVENHTFFRLERPVPPER 318

  Fly   329 --FLN-ISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSK----RLLGAAGGVGTSGSS--- 383
              ||: .:|||||.|.||||.|:||..|:||..::||.|||||    ||:........|.:|
Zfish   319 NLFLHYFTLGSKFRYCGRTEAQSVQYGKERGNKNRVFARSPSKPLVRRLMSGLDWETVSRNSLSD 383

  Fly   384 ---------GGTP--MQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKA 437
                     ..:|  ...||.|.........:|:..|.::.......|.......|.|.|
Zfish   384 DRLETQSLPNRSPPDSPDHSNSVFTTEGARIRPSSIGHLVDHVIDDSPCQTFTNHKSASS----- 443

  Fly   438 WEQQSDEYDIQLDVGFIEQCTRRFESASPSP------MPPAY---------------SSGQHS-- 479
                :....|.||             ::|||      .|||.               |..||.
Zfish   444 ----TQANSISLD-------------STPSPDVTTDEQPPALPPKQFRKDPLNHNGRSQSQHELD 491

  Fly   480 -----------PILLPTTIADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSK 533
                       |.....::..||.|      .:|:.|:::.||.||:|||||||||..:|:.||:
Zfish   492 DHDHLSELYNVPAASGKSMNGAVPH------DNLVLIKMRPDENGRFGFNVKGGVDQRMPIIVSR 550

  Fly   534 VVPHTPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPL-- 596
            |.|.||||.|.||:.|||:|::|||||:....|:.||.:|:......||||:|.|||.....:
Zfish   551 VAPGTPADMCVPRLNEGDQVVLINGRDISDHTHDDVVMIIKASCEDQSGELILLVRPNAIYDVDE 615

  Fly   597 ---LLEEEPLYQYVPESDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAI 658
               .|:.||.:||:||:..:.|||   :.|:| ..|:.||.||||||.:.||::.:|||.|.:::
Zfish   616 EQEKLDLEPDFQYIPEACGLESHS---EADSL-RSSIQLLRDGLASGTVPAQFDQLYRKRPGMSM 676

  Fly   659 TEARKPANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPG-GAVNRYIATQGPLASTT 722
            :.||.|.|..|||||||||||.|||.|..  |.||||||::||::|. |.|.||||.||||..|.
Zfish   677 SCARLPQNVSKNRYRDISPYDSTRVVLKG--TEDYINANFINMDVPSKGEVRRYIACQGPLPGTC 739

  Fly   723 TDFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFRE 787
            :|||:||.::|:.|:|||||.:|.||.|||||||......... ||.|.|:||  :...:::.|:
Zfish   740 SDFWQMVWEQSAALVVMLTTQVERGRVKCHQYWPNVSASGTYG-GFQVTCVSE--EGNSAYLLRD 801

  Fly   788 FVLK--DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDA 850
            ..|.  :..|:|.|..|||||||||.||.|.:.||.|..:||:.|
Zfish   802 LTLTHLESKEERQICQMQYLAWPDHGVPDDSSDFLNFVSQVRSKR-------------------- 846

  Fly   851 DADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTA 915
             ||..|                                     ||:||||||||||||||.|:||
Zfish   847 -ADGPE-------------------------------------PVVVHCSAGIGRTGVLITMETA 873

  Fly   916 LALMEAREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY 959
            :.|:|..:.|||||||||||||||.|:|..||||||||.|...|
Zfish   874 MCLIEGGQSVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY 917

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	96/196 (49%)
		FERM_N	38..102	CDD:286467	30/63 (48%)
		FERM_M	125..232	CDD:278785	53/106 (50%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	48/93 (52%)
		FA	333..369	CDD:285894	23/39 (59%)
		PDZ_signaling	502..589	CDD:238492	45/86 (52%)
		Y_phosphatase	666..955	CDD:278528	137/291 (47%)
		PTPc	668..955	CDD:238006	136/289 (47%)
ptpn4b	XP_005174003.1	B41	30..222	CDD:214604	96/197 (49%)
		FERM_N	33..97	CDD:286467	30/63 (48%)
		FERM_B-lobe	122..214	CDD:271216	44/91 (48%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	48/93 (52%)
		FA	325..365	CDD:285894	23/39 (59%)
		PDZ_signaling	519..606	CDD:238492	45/86 (52%)
		PTPc	662..915	CDD:214550	147/315 (47%)
		PTPc	687..914	CDD:238006	136/289 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2756
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	661	1.000	Inparanoid score	I740
OMA	1	1.010	-	-		QHG49050
OrthoDB	1	1.010	-	-		D59173at33208
OrthoFinder	1	1.000	-	-		FOG0006212
OrthoInspector	1	1.000	-	-		otm24313
orthoMCL	1	0.900	-	-		OOG6_104957
Panther	1	1.100	-	-	O	PTHR45706
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5775
SonicParanoid	1	1.000	-	-		X1974
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.870