DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and rhea

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001246674.1	Gene:	rhea / 38978	FlyBaseID:	FBgn0260442	Length:	2836	Species:	Drosophila melanogaster

Alignment Length:	1043	Identity:	213/1043 - (20%)
Similarity:	336/1043 - (32%)	Gaps:	329/1043 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 TRTFRLR---GGGPELARDKKTPQRQQCVTVLFLDDITH-----TFRIEKRAKGSELLDQVFQYL 67
            |||.|:|   |....:..|...|..|..|.:.....||:     ..|.:..|:...|.|..|..|
  Fly    87 TRTLRVRMLDGAVKTILVDDSQPVSQLMVVICTKIGITNHEEYGLVREDNEAQNENLPDNKFGTL 151

  Fly    68 EL------SERD--YFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVS-- 122
            .|      .:||  ...|....|..|.:.|||..:..::|    .:|.....||  |.:||.|
  Fly   152 TLKRKIMEKDRDAKMESLRKKLKTDDEMNWVDVSRTLREQ----GIDEAETVLL--RRRFFFSDQ 210

  Fly   123 -----DPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLS 182
                 ||.:|.      ..|:|.:..||.|..|.:.:..|..|...|..:.|..|..:|:.|:|.
  Fly   211 NIDSRDPVQLN------LLYVQARDAILDGTHPVTQDKACEFAGIQVHIQFGPHNEAKHKTGFLD 269

  Fly   183 GMQLLCD---QTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDS-NGKE-- 241
            ....|..   :|...|:|:...|:.|......||:..|.:.|:.|..||:......:. |||.
  Fly   270 LKDFLPQSYVRTKGIEKKIFSEHRKHVDLSEIDAKVLYTKTARELPTYGVTFFLVKEKMNGKNKL 334

  Fly   242 --LQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHA 304
              ..|||:...:|......:....||.            ...:||..:......|.||..:::
  Fly   335 VPRLLGVTKDSVLRLDEHTKEILISWP------------LTTVRRWGASPNTFTLDFGDYANQ-- 385

  Fly   305 KALWKSCVEHHSFFRLKRPHRLSRFLNISLGSKFYYSGRTELQAVQESKQ-----RGRIHKVFVR 364
                                              |||.:|     .|::|     .|.|..:..:
  Fly   386 ----------------------------------YYSVQT-----TEAEQIVQLIAGYIDIILKK 411

  Fly   365 SPSKRLLGAAGGVGTS------GSSGGTPMQQHSG-SESANSHNNGKPAGAGTILTITKTSRPHD 422
            ..:|...|..|..|::      ..|..|.:|..:. .|..|..:...|.          ..||:|
  Fly   412 KQTKDHFGIEGDEGSTMVEESVAPSKATFLQHETNRMEQLNVESLAHPG----------IMRPYD 466

  Fly   423 NKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTI 487
            .:.:..|.        |.|:.:|.     .|:.|.....:       ||.....:.|.:.|....
  Fly   467 GERSYMEN--------EVQTVQYG-----AFVGQVNHAHQ-------PPTTKEVRISSVNLTEPQ 511

  Fly   488 ADAVGHQQPESGSDLITIRLQADEQGR-------YGFNVK------GGVDLSLPVQVSKVVPHTP 539
            ...:|:  ..:|.|::   ::|||:.|       .|.:::      ..:|.|.....|.|...:.
  Fly   512 RALLGY--ISAGQDVL---IRADEELRTKAPIQELGSDLRSIEWRENTLDTSKQAVSSHVATMSA 571

  Fly   540 ADRCTPRVCEGDEV----------------------------LMINGRDVHGLRHEQVVAMIRD- 575
            |..........|||                            ||.|  |..|   :|::...|:
  Fly   572 ATAQIITASHPDEVDTEAISASVSQIAQTIPEVTKEVRLIAALMEN--DTSG---DQLLEAARNL 631

  Fly   576 CRHQASGELLLTVRPQRSAP--------------------LLLEEEPLYQYVPESDEIGSHSNLL 620
            |  .|..:||....|:...|                    .:.|||     |||:.::  |..||
  Fly   632 C--SAFSDLLKAAEPESKEPPQHLINAASRVGEATTHVLSTIAEEE-----VPENRDL--HDMLL 687

  Fly   621 ---DGDALFTQSLLLLSD----------------GLASGALLAQYELMYRKNPDLAITEARKPAN 666
               ...|..|.:|:|.:.                |.||...||..:|:
  Fly   688 ALAKAVANTTAALVLRAKNIAASCDDEQARNRVIGAASQCALATSQLV----------------- 735

  Fly   667 APKNRYRDISPYDCTRV---SLVNSLTGDYINANYVNMEIPGGAVNRYI-----ATQGPLASTTT 723
                        .|.:|   :|.|:...:.:.|...|:   ..|||...     |:..|  ....
  Fly   736 ------------ACAKVVAPTLHNAACREQLEAAAKNV---ARAVNSLCEVCNEASNDP--KLKA 783

  Fly   724 DFWRMVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAE----GFSVRCLSEKPDE----- 779
            |.....:..|..|..||..|..|.|:..::    |..||...|    |..:...:..|.|
  Fly   784 DLLAAARDVSKSLTDMLEHVKLSSREHANR----TSTELSPVENVIIGTDILVSTHDPQEMVRHA 844

  Fly   780 -----TGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAAR--------- 830
                 |.:.:.:.  :|.:.:|:....|:     .|.:.:...|.....:.|.|||
  Fly   845 RTLGQTTAQLIQS--IKGEADQQQDADMK-----RHLLSAAKQLADATAKLVEAARLCSSNPHDS 902

  Fly   831 -NRTLLQEIEESLKQVRLMDADADADENGGLMRERKCA--ASNGATPEDETPVSTSVHQCISAAN 892
             |:..|::..|.|:::....|:..|.:.|.:.|...|:  |::.||            ||||||.
  Fly   903 DNQNALRKAAEELREITTTAANTPAMKRGLIQRLEFCSKQAASAAT------------QCISAAQ 955

  Fly   893 PPV 895
            ..|
  Fly   956 NAV 958

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	56/219 (26%)
		FERM_N	38..102	CDD:286467	18/76 (24%)
		FERM_M	125..232	CDD:278785	28/109 (26%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	16/98 (16%)
		FA	333..369	CDD:285894	8/40 (20%)
		PDZ_signaling	502..589	CDD:238492	24/128 (19%)
		Y_phosphatase	666..955	CDD:278528	55/264 (21%)
		PTPc	668..955	CDD:238006	55/262 (21%)
rhea	NP_001246674.1	FERM_f0	4..85	CDD:293120
		B41	89..322	CDD:214604	63/244 (26%)
		FERM_N	92..147	CDD:286467	12/54 (22%)
		FERM_M	215..322	CDD:278785	30/112 (27%)
		FERM_C_Talin	318..409	CDD:269973	23/143 (16%)
		Talin_middle	510..668	CDD:286254	29/169 (17%)
		I_LWEQ	686..>778	CDD:302998	22/123 (18%)
		Vinculin	<874..>1035	CDD:279395	24/97 (25%)
		talin-RS	1661..1832	CDD:213393
		Tar	<1694..2005	CDD:223910
		VBS	1859..1982	CDD:286057
		I_LWEQ	2392..2534	CDD:279885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910