DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and RhoGEF4

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_648101.1	Gene:	RhoGEF4 / 38806	FlyBaseID:	FBgn0035761	Length:	647	Species:	Drosophila melanogaster

Alignment Length:	434	Identity:	87/434 - (20%)
Similarity:	147/434 - (33%)	Gaps:	143/434 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVV 87
            |.:.:..|:.|:.:..|.:..|....|.:.      ||:||..|...::.||
  Fly   181 LEQTESRPEVQRKLNSLMIVPIQRVPRYKL------LLEQVLLYTSPADADY------------- 226

  Fly    88 RWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRL-----QEEFTRYQFYLQIKRNILLG 147
                                   .||:..||...:..|.:     ::|.|:|..:||   |.|:.
  Fly   227 -----------------------KLLKESVKEIEATASHINTCVEEQEITQYLIHLQ---NSLVN 265

  Fly   148 KLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAER------KVGELHKLHR 206
            :.|     ..:..|..|..|           |.|   |.:..:.||.:|      .:....|:.:
  Fly   266 RTP-----NIVKPSRRVIKE-----------GVL---QKITHKGTEIKRYCVLMSDIFMYCKMIK 311

  Fly   207 GQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKV 271
            .:.|.....|.||......|....::.....|.|   |...:.|::.....::::. :|     |
  Fly   312 ERAPNTVVENSLECCCIFPLKKCKVYEMLPGNFK---LTCQSDGIIFGSGDVQLSR-TW-----V 367

  Fly   272 SFKRK--DFFIQLR---------REPSENYDTLLGFG----MSSHKHAKALWKSCVEHHSFFRLK 321
            .|.|.  |..:|.|         |.|....| :..||    :|.:|      :.| |:.:.||.|
  Fly   368 GFIRDAIDLHVQCRKTLRKDSSKRTPIRKKD-MKKFGADYVLSPNK------RKC-EYDTVFRNK 424

  Fly   322 RPHRLSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKV---FVRSPSKRLLGAAGGVGTSGSS 383
                     |.|..|:         :..::|....|..||   .:|:|:...:|.|    :|.||
  Fly   425 ---------NRSTDSE---------EETEDSACFSRKRKVASGILRAPNGNPMGKA----SSSSS 467

  Fly   384 GGTPMQQHSGSESA--------NSHNNGKPAGAGTILTITKTSR 419
            ....|::.:....|        ..|..|:|   |.:.|.:|.:|
  Fly   468 SSVSMKRVAPPPPAPPPPPAVQMRHQPGRP---GELATASKENR 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	38/207 (18%)
		FERM_N	38..102	CDD:286467	10/63 (16%)
		FERM_M	125..232	CDD:278785	24/117 (21%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	22/108 (20%)
		FA	333..369	CDD:285894	8/38 (21%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
RhoGEF4	NP_648101.1	RhoGEF	74..244	CDD:279015	18/104 (17%)
		PH-like	269..>311	CDD:302622	10/55 (18%)
		PH	277..374	CDD:278594	22/119 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910