DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and cora

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_523791.2	Gene:	cora / 37205	FlyBaseID:	FBgn0010434	Length:	1698	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	223/774 - (28%)
Similarity:	345/774 - (44%)	Gaps:	165/774 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKP 83
            |.|.|||            |..||.......|:::|.|.::::.:...|.|.|:|||||.: :.|
  Fly    29 GKPALAR------------VTLLDGSLLDVSIDRKAIGRDVINSICAGLNLIEKDYFGLTY-ETP 80

  Fly    84 GDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGK 148
            .|...|:|.:|...|     ....|..| |.|.|||:..:||:|:|:.|||...||::.:||.|:
  Fly    81 TDPRTWLDLEKPVSK-----FFRTDTWP-LTFAVKFYPPEPSQLKEDITRYHLCLQVRNDILEGR 139

  Fly   149 LPCSSNTQCLLASYTVQSELGDFNALEHQP--GYLSGMQLLCDQTTEAERKVGELHKLHRGQLPA 211
            |||:..|..||.||.||||:||::| |..|  .||...::..:||.|.|.||.:|||.|:||.||
  Fly   140 LPCTFVTHALLGSYLVQSEMGDYDA-EEMPTRAYLKDFKIAPNQTAELEDKVMDLHKTHKGQSPA 203

  Fly   212 DAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKRK 276
            :||.:|||:||:|.:||:|||.|.||.|.::.|||.|.||||::..||:|.|:|.|::|:|:||.
  Fly   204 EAELHYLENAKKLAMYGVDLHPAKDSEGVDIMLGVCASGLLVYRDKLRINRFAWPKILKISYKRH 268

  Fly   277 DFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLSRFLNISL-GSKFYY 340
            .|:|::|....|.|::.:||.:::|:.||.|||||||||:||||..|..:|:.....: ||.:.|
  Fly   269 HFYIKIRPGEFEQYESTIGFKLANHRAAKKLWKSCVEHHTFFRLMTPEPVSKSKMFPVFGSTYRY 333

  Fly   341 SGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQ------------HSG 393
            .|||:.::......         |:|.|.....:|...||.|.....:.:            |.|
  Fly   334 KGRTQAESTNTPVD---------RTPPKFNRTLSGARLTSRSMDALALAEKEKVARKSSTLDHRG 389

  Fly   394 SESA--NSHN-----NGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDV 451
            ..:|  ::|:     |.|...|      .|.::..:.|  .||.:...||..|::.
  Fly   390 DRNADGDAHSRSPIKNKKEKDA------DKEAKLREKK--QKEKEEKERKEREKRE--------- 437

  Fly   452 GFIEQCTRRFESASPSPMPPA------------------------------YSSGQHSPILLPTT 486
              :|: .::.|.|:.:.:...                              :|||:.|....|:.
  Fly   438 --LEE-KKKAEKAAKAALAAGAAAGAAVNGNDELNDSNKSDKSSGRRGVGIFSSGRKSKSGSPSK 499

  Fly   487 IADAVGHQQPESGSDLITIRLQADEQGRYGFNVKGGV-DLSLPVQVSKVVPHTPADR--CTPRVC 548
                  ..:.:||.|      :..|.||.|..|..|: |......:.:...:...:|  .||.|.
  Fly   500 ------DGKDKSGKD------KDKEVGRLGLVVTSGLGDNQQDQNLDEAARNAAKNRGSTTPGVT 552

  Fly   549 EGDEVLMINGRDVH---------GLRHEQVVAMIRDCRHQASG----ELLLTVRPQRSAPLLLEE 600
            ...|..:.|..:..         |.|::|      |...:.||    |.|.....|:...|
  Fly   553 RQYEYAVDNDGNTSPTRKSYTPGGFRYDQ------DPNSRKSGADGQEQLSPTSQQKKIGL---- 607

  Fly   601 EPLYQYVPESDE-IGSHSNLLDGDALF--TQSLL------------LLSDGLASGALLAQYELMY 650
              .:.|.|.::. :...:..|....|.  ||..|            ||.|.|.|....|:.:...
  Fly   608 --AFNYAPGNENALKETAEKLKAGQLSPRTQDKLNRGQLSPKSRAKLLQDPLLSPTTRAKLQGSA 670

  Fly   651 RKNPDLAITEARK----PANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPG 705
            .....:.:::::|    |...|:. |...:|.....:|   ..|.|::.:...|.| ||
  Fly   671 VDAAAVPLSDSQKRSYSPTKGPQG-YSSGAPGSYKPIS---DPTADFLESQRYNKE-PG 724

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	83/198 (42%)
		FERM_N	38..102	CDD:286467	20/63 (32%)
		FERM_M	125..232	CDD:278785	55/108 (51%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	48/93 (52%)
		FA	333..369	CDD:285894	8/36 (22%)
		PDZ_signaling	502..589	CDD:238492	21/102 (21%)
		Y_phosphatase	666..955	CDD:278528	10/40 (25%)
		PTPc	668..955	CDD:238006	10/38 (26%)
cora	NP_523791.2	B41	34..224	CDD:214604	85/209 (41%)
		FERM_N	36..98	CDD:286467	20/67 (30%)
		FERM_M	116..224	CDD:278785	55/108 (51%)
		FERM_C_4_1_family	219..312	CDD:270005	48/92 (52%)
		FA	323..363	CDD:285894	10/48 (21%)
		PQQ_2	829..>972	CDD:290097
		4_1_CTD	1612..1698	CDD:283537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	106	1.000	Domainoid score	I4108
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D29979at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.920