DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and epb41l5

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_956383.1	Gene:	epb41l5 / 368449	ZFINID:	ZDB-GENE-030616-450	Length:	772	Species:	Danio rerio

Alignment Length:	470	Identity:	158/470 - (33%)
Similarity:	230/470 - (48%)	Gaps:	66/470 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 VLFLDDITHTFRIEKRAKGSELLDQVFQYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQ--- 99
            |..||....:..:.|:|||:||.:|:..:|::.|:|||||.| .....|..|:|..|..|||
Zfish    47 VSLLDGTDVSVDLPKKAKGAELFEQIMYHLDVVEKDYFGLRF-MDSAQVPHWLDVTKSIKKQVKI 110

  Fly   100 ----CSSVSLDNDAVPLLEFRVKFFVSDPSRLQEEFTRYQFYLQIKRNILLGKLPCSSNTQCLLA 160
                |            |..||||:.|:|:.|.||.|||.|.||:|::||.|||.|..:|...||
Zfish   111 GPPYC------------LHMRVKFYSSEPNNLHEELTRYLFVLQLKQDILSGKLECPFDTTVELA 163

  Fly   161 SYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVGELHKLHRGQLPADAEYNYLEHAKRLE 225
            ||.:|:||||::..||....:|..:.:.:||.:.|..:....|..|||.||.||.|||..||.||
Zfish   164 SYALQAELGDYDPAEHGLDLVSEFRFIPNQTEDMEVAIYNAWKECRGQTPAQAEINYLNKAKWLE 228

  Fly   226 LYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFSWSKMVKVSFKR----------KDFFI 280
            :||:|:|.....:|.|..||::..|:|||:...::..|.|.|:.::.||:          .:..:
Zfish   229 MYGVDMHMVKARDGNEYSLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKCKLTLVVVEDDEQVM 293

  Fly   281 QLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKRPHRLS--RFLNISLGSKFYYSGR 343
            |...|..|...|.: |.|...|..|.|||..||||:||||:.|.:.|  |...|.:||:|.|||:
Zfish   294 QETEEGKEQEHTFV-FRMDHPKACKHLWKCAVEHHAFFRLRGPVQKSSARSGFIRMGSRFRYSGK 357

  Fly   344 TELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQQHSGSESANSHNNG----- 403
            ||.|..:.:|.|....  |.|.||:|.             ....|.....::|:::||||
Zfish   358 TEYQTTKANKARRSAS--FERRPSRRY-------------SRRTMLNRGPNKSSDNHNNGVSPSI 407

  Fly   404 -------KPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQLDVGFIEQCTRRF 461
                   :|..:|..:..:..|.|     ...|.:::||.....|||:..:.:....:|.|....
Zfish   408 EKKPTHTRPPWSGMPVVSSPPSAP-----GPMEIETLPRSPGGSQSDKRSMPIVTDLLETCVDEV 467

  Fly   462 ESASPSPMPPAYSSG 476
            ..|: .||.....:|
Zfish   468 LQAT-VPMATVEEAG 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	83/200 (42%)
		FERM_N	38..102	CDD:286467	26/70 (37%)
		FERM_M	125..232	CDD:278785	50/106 (47%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	34/103 (33%)
		FA	333..369	CDD:285894	15/35 (43%)
		PDZ_signaling	502..589	CDD:238492
		Y_phosphatase	666..955	CDD:278528
		PTPc	668..955	CDD:238006
epb41l5	NP_956383.1	B41	44..235	CDD:214604	83/200 (42%)
		FERM_N	47..109	CDD:286467	25/62 (40%)
		FERM_B-lobe	135..227	CDD:271216	42/91 (46%)
		FERM_C_NBL4_NBL5	231..331	CDD:270007	32/100 (32%)
		FA	344..>375	CDD:285894	12/32 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910