DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and ptpn4a

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	NP_001007201.1	Gene:	ptpn4a / 368448	ZFINID:	ZDB-GENE-030616-449	Length:	921	Species:	Danio rerio

Alignment Length:	1014	Identity:	414/1014 - (40%)
Similarity:	567/1014 - (55%)	Gaps:	164/1014 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MFERFRLNNLTRTFRLRGGGPELARDKKTPQRQQCV-TVLFLDDITHTFRIEKRAKGSELLDQVF 64
            |..|||| ...|::.:|  ..|||||:   ||.:.| .:|.||:....|::.|..:|..|||.||
Zfish     1 MTARFRL-PAGRSYNVR--TTELARDR---QRTEVVCNILLLDNTVQPFKVNKHDQGQILLDAVF 59

  Fly    65 QYLELSERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVPLLEFRVKFFVSDPSRLQE 129
            ::|||:|||||||....:|.|..||:|..|..:||     |...:...|.||||||||||::|||
Zfish    60 KHLELTERDYFGLHLADEPSDSPRWLDPNKPIRKQ-----LKRGSPHHLNFRVKFFVSDPNKLQE 119

  Fly   130 EFTRYQFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEA 194
            |:||||::||||::||.|:|||..||..|||||.|||||||::..|:.|||||....:.:|....
Zfish   120 EYTRYQYFLQIKQDILSGRLPCPHNTAALLASYAVQSELGDYSEAENLPGYLSEFFFIPNQPQGF 184

  Fly   195 ERKVGELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLR 259
            |:.|.:.|:.|.|..||.:|:|||..|:.|:|||::||.|.|.:..|:.:||.:.|:.::::.:|
Zfish   185 EKDVAKHHQQHNGLNPAQSEFNYLNTARTLDLYGVELHYARDQSNTEIYVGVLSAGIGIYKNRVR 249

  Fly   260 VNTFSWSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR-- 322
            :|.|.|.|:||:|||.|.||||||:|..:..||||||.|.:::..|.|||:|||||:||||.|
Zfish   250 INYFPWLKIVKISFKCKQFFIQLRKEAHDTRDTLLGFNMVNYRACKNLWKTCVEHHTFFRLDRPV 314

  Fly   323 PHRLSRFLN-ISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSP-SKRLLGAAGGVGTSGSS-- 383
            |.:.:.|.: .||||:|.|.||||.|:||..|::|...:||...| :::|:|.......|.:|
Zfish   315 PPQKNFFAHYFSLGSRFRYCGRTEAQSVQYGKEKGIKDRVFASKPLARKLMGVTDWEAVSRNSLS 379

  Fly   384 ------GGTPMQQHSGSESANS--HNNG---KPAGAGTILTITKTSRPHDNKVTSKEADSMP--- 434
                  ...|.:...|:.:.||  ...|   :|:..|.::.....:.|           |:|
Zfish   380 EERLETRSLPTRSPPGTPNHNSLFVQEGPRLRPSSMGHLVDHVIHASP-----------SLPVFS 433

  Fly   435 --RKAWEQQSDEYDIQLDVGFIEQCTRRFESASPSP---------MPPAYSSGQHSPILLPTTIA 488
              :.|...|::...::               ::|||         :||..|....|.::|..:..
Zfish   434 NHKSASSTQANSISLE---------------STPSPEGVEGPPPALPPKQSRKNLSQLILSHSQQ 483

  Fly   489 DAVGH-------------QQPES---GSDLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPH 537
            |...|             ..|..   ..:|:.|:::.||.||:|||||||.|..:|:.||:|.|.
Zfish   484 DLDNHINEMYDVPTATDKVMPNGVVPHDNLVLIKMKPDENGRFGFNVKGGSDQKMPIIVSRVAPG 548

  Fly   538 TPADRCTPRVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQRSAPLL---LE 599
            |.||.|.||:.|||:|::||||::....|:|||..|:......||||:|.|||.....::   ||
Zfish   549 TSADLCVPRLNEGDQVVLINGREIAEHSHDQVVMFIKASCESHSGELILLVRPNAIYDVVEEKLE 613

  Fly   600 EEPLYQYVPE-SDEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARK 663
            .||.:||:|| |....||   ||.|| :..|:|.|.:||.||.:|||::.:|||.|.:.::.|:.
Zfish   614 TEPDFQYIPEKSPTDPSH---LDQDA-WRDSMLYLKEGLNSGTILAQFDQLYRKRPGMTMSCAKL 674

  Fly   664 PANAPKNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIPG-GAVNRYIATQGPLASTTTDFWR 727
            |.|..|||||||||||.|||.|..  |.|||||||:|||||. ..:|||||.||||.:|.:|||:
Zfish   675 PQNISKNRYRDISPYDATRVILKG--TEDYINANYINMEIPACSLINRYIACQGPLPNTCSDFWQ 737

  Fly   728 MVQQESSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEGFSVRCLSEKPDETGSFVFREFVLK- 791
            |..::.|.::|||||     :.|||||||......... ||.:.|.:|  :...:|:.||..|.
Zfish   738 MTWEQGSSMVVMLTT-----QVKCHQYWPNPSGSATYG-GFQISCQTE--EGNSAFLVREITLTH 794

  Fly   792 -DKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADAD 855
             :..|.|.:..:||||||||.||.|...||:|...||..|                     |..|
Zfish   795 IESGESRELTQIQYLAWPDHGVPDDSTDFLDFVALVRNKR---------------------AGKD 838

  Fly   856 ENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALME 920
            |                                     ||:||||||||||||||.|:||:.|||
Zfish   839 E-------------------------------------PVVVHCSAGIGRTGVLITMETAMCLME 866

  Fly   921 AREPVYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY 959
            ..:||:||:||||||||||.|:|..||::||||.|...|
Zfish   867 CSQPVFPLEIVRTMRDQRAMMIQTPSQFKFVCEAILKVY 905

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	97/197 (49%)
		FERM_N	38..102	CDD:286467	29/63 (46%)
		FERM_M	125..232	CDD:278785	55/106 (52%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	47/93 (51%)
		FA	333..369	CDD:285894	18/36 (50%)
		PDZ_signaling	502..589	CDD:238492	43/86 (50%)
		Y_phosphatase	666..955	CDD:278528	130/291 (45%)
		PTPc	668..955	CDD:238006	129/289 (45%)
ptpn4a	NP_001007201.1	B41	30..222	CDD:214604	97/196 (49%)
		FERM_N	33..97	CDD:286467	30/68 (44%)
		FERM_B-lobe	122..214	CDD:271216	47/91 (52%)
		FERM_C_PTPN4_PTPN3_like	216..310	CDD:270010	47/93 (51%)
		FA	325..364	CDD:285894	18/38 (47%)
		PDZ_signaling	513..600	CDD:238492	43/86 (50%)
		PTPc	653..903	CDD:214550	140/317 (44%)
		PTPc	680..902	CDD:238006	129/289 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2756
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2120
Inparanoid	1	1.050	661	1.000	Inparanoid score	I740
OMA	1	1.010	-	-		QHG49050
OrthoDB	1	1.010	-	-		D59173at33208
OrthoFinder	1	1.000	-	-		FOG0006212
OrthoInspector	1	1.000	-	-		otm24313
orthoMCL	1	0.900	-	-		OOG6_104957
Panther	1	1.100	-	-	O	PTHR45706
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5775
SonicParanoid	1	1.000	-	-		X1974
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	14.010