DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptpmeg and Ptpn3

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_001059757.1	Gene:	Ptpn3 / 362524	RGDID:	1311363	Length:	1018	Species:	Rattus norvegicus

Alignment Length:	1010	Identity:	360/1010 - (35%)
Similarity:	529/1010 - (52%)	Gaps:	174/1010 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RLNNLTRTFRLRGGGPELARDKKTPQRQQCVTVLFLDDITHTFRIEKRAKGSELLDQVFQYLELS 70
            |:||: ||..|    |:    :||.....| ::.|||.:..||::.|:..|..|||..:.:|.::
  Rat   116 RINNI-RTSEL----PK----EKTRSEVTC-SIRFLDGLVQTFKVNKQDLGQSLLDMAYGHLGVT 170

  Fly    71 ERDYFGLLFPQKPGDVVRWVDAQKQFKKQCSSVSLDNDAVP-LLEFRVKFFVSDPSRLQEEFTRY 134
            |::||||.....|.|..||::|.|..:||...      .:| :|.|||::|:.||:.||:|.||:
  Rat   171 EKEYFGLQHGDDPVDSPRWLEASKPLRKQLKG------GLPCILHFRVRYFIPDPNTLQQEQTRH 229

  Fly   135 QFYLQIKRNILLGKLPCSSNTQCLLASYTVQSELGDFNALEHQPGYLSGMQLLCDQTTEAERKVG 199
            .::||:|.::..|:|.|..|:..:||||.|||.:||||:..|.||||:..|.:.||..:...||.
  Rat   230 LYFLQLKMDVCEGRLTCPLNSAVVLASYAVQSHIGDFNSSIHHPGYLADSQFIPDQNDDFLSKVE 294

  Fly   200 ELHKLHRGQLPADAEYNYLEHAKRLELYGIDLHRATDSNGKELQLGVSAVGLLVFQHSLRVNTFS 264
            .||:.|.|...::||..|:..|:.|:.||::||...|.:..:|.:|:::.|:.|::..:..:.:.
  Rat   295 SLHEQHSGLKQSEAESCYINIARTLDFYGVELHGGRDLHNLDLMIGIASAGIAVYRKYICTSFYP 359

  Fly   265 WSKMVKVSFKRKDFFIQLRREPSENYDTLLGFGMSSHKHAKALWKSCVEHHSFFRLKR--PHR-- 325
            |..::|:|||||.|||..|::.:|:.:.::.|.|.:::..|.||||||||||||:.|:  |..
  Rat   360 WVNILKISFKRKKFFIHQRQKQAESREHIVAFNMLNYRSCKNLWKSCVEHHSFFQAKKLLPQEKN 424

  Fly   326 -LSRFLNISLGSKFYYSGRTELQAVQESKQRGRIHKVFVRSPSKRLLGAAGGVGTSGSSGGTPMQ 389
             ||::.  :|||      |...::|.....: ::....|.:|..|...:...:.|......:|..
  Rat   425 VLSQYW--TLGS------RNPKKSVNNQYCK-KVIGGMVWNPVMRRSLSVERLETKSLPSRSPPI 480

  Fly   390 QHSGSESANSHNNGKPAG------AGTILTITKTS---RPHDNKVTSKEADS------MPRKAWE 439
            ..:.......|...||..      |..:..||:|.   ..:...::.|::||      .|.:...
  Rat   481 TPNWRSPRLRHEIRKPRHSSADNLANEMTYITETEDVFYTYKGSLSPKDSDSEVSQNHSPHRGSL 545

  Fly   440 QQSDEYDIQLDVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVG-------HQQPE 497
            .:::.         .:.|..:..|:|.||...|  .|..||        |.|.       |:..:
  Rat   546 SENNP---------AQSCLTQKSSSSVSPCSNA--PGSFSP--------DGVDQQFLEDYHKVTK 591

  Fly   498 SGS-----------------DLITIRLQADEQGRYGFNVKGGVDLSLPVQVSKVVPHTPADRCTP 545
            .||                 .|:.||:..|::||:|||:|||||..:|:.||::.|.:|||.|.|
  Rat   592 GGSIEEASQYYCDKNDDGDGYLVLIRITPDKEGRFGFNLKGGVDQKMPLVVSRINPESPADTCMP 656

  Fly   546 RVCEGDEVLMINGRDVHGLRHEQVVAMIRDCRHQASGELLLTVRPQ--RSAPLLLEEEPLYQYVP 608
            ::.|||::::|||||:....|:|||..|:..|...|.||.|.:|.:  ||...:..|:.|.|..|
  Rat   657 KLNEGDQIVLINGRDISEHTHDQVVMFIKASRESHSRELALVIRRKAVRSLAEIRSEDELSQLFP 721

  Fly   609 ES-----DEIGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELMYRKNPDLAITEARKPANAP 668
            |:     .|        .||:| ..|:.||..||.||.:|.|:|.:|||.|.||:|.|:.|.|..
  Rat   722 EAMFPACPE--------GGDSL-EGSMELLKKGLESGTVLIQFEQLYRKKPGLAVTFAKLPQNLD 777

  Fly   669 KNRYRDISPYDCTRVSLVNSLTGDYINANYVNMEIP-GGAVNRYIATQGPLASTTTDFWRMVQQE 732
            ||||:|:.|||.|||.|..:  .|||||:||||||| ...||:||||||||..|...||::|..:
  Rat   778 KNRYKDVLPYDTTRVLLQGN--EDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQ 840

  Fly   733 SSHLLVMLTTVMESGRQKCHQYWPVTGEELQLAEG-FSVRCLSEKPDETGSFVFREFVLKDKH-- 794
            ...|:|||||:.|.||.|||||||...:.:.  .| |.::|.:|  |.|.::|.||.::.:..
  Rat   841 KLSLVVMLTTLTERGRTKCHQYWPDPPDIMD--HGIFHIQCQAE--DCTIAYVSREMLVTNTETG 901

  Fly   795 EQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRTLLQEIEESLKQVRLMDADADADENGG 859
            |:..:.|:||:|||||.||.|.:.||||.:.||:.|
  Rat   902 EEHTVTHLQYVAWPDHGVPDDSSDFLEFVKYVRSLR----------------------------- 937

  Fly   860 LMRERKCAASNGATPEDETPVSTSVHQCISAANPPVIVHCSAGIGRTGVLILMDTALALMEAREP 924
                                          ....|.:|||||||||||||:.|:||:.|:|...|
  Rat   938 ------------------------------VGGEPALVHCSAGIGRTGVLVTMETAMCLIERNLP 972

  Fly   925 VYPLDIVRTMRDQRACMVQNVSQYRFVCECICAAY 959
            ||||||||.||||||.|||..|||:||||.|...|
  Rat   973 VYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604	77/197 (39%)
		FERM_N	38..102	CDD:286467	24/63 (38%)
		FERM_M	125..232	CDD:278785	44/106 (42%)
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010	36/93 (39%)
		FA	333..369	CDD:285894	7/35 (20%)
		PDZ_signaling	502..589	CDD:238492	41/86 (48%)
		Y_phosphatase	666..955	CDD:278528	127/292 (43%)
		PTPc	668..955	CDD:238006	126/290 (43%)
Ptpn3	XP_001059757.1	B41	135..327	CDD:214604	77/198 (39%)
		FERM_N	138..201	CDD:286467	24/62 (39%)
		FERM_M	220..327	CDD:278785	44/106 (42%)
		FERM_C_PTPN4_PTPN3_like	321..414	CDD:270010	35/92 (38%)
		PDZ_signaling	613..700	CDD:238492	41/86 (48%)
		PTPc	754..1005	CDD:214550	139/315 (44%)
		PTPc	777..1004	CDD:238006	126/291 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	193	1.000	Domainoid score	I3098
eggNOG	1	0.900	-	-		E2759_KOG0792
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	639	1.000	Inparanoid score	I789
OMA	1	1.010	-	-		QHG49050
OrthoDB	1	1.010	-	-		D59173at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46330
orthoMCL	1	0.900	-	-		OOG6_104957
Panther	1	1.100	-	-	LDO	PTHR45706
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1974
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.840