DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptpmeg and Fgd3

DIOPT Version :9

Sequence 1:	NP_001163309.2	Gene:	Ptpmeg / 38059	FlyBaseID:	FBgn0261985	Length:	974	Species:	Drosophila melanogaster
Sequence 2:	XP_008769765.1	Gene:	Fgd3 / 361223	RGDID:	1311725	Length:	733	Species:	Rattus norvegicus

Alignment Length:	656	Identity:	131/656 - (19%)
Similarity:	217/656 - (33%)	Gaps:	221/656 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   385 GTPMQQHSGSESANSHNNGKPAGAGTILTITKTSRPHDNKVTSKEADSMPRKAWEQQSDEYDIQL 449
            |.|......|.||...:.|:|:||   :.|.......::..:|..:::.|
  Rat    41 GAPQGAQGSSASAGDSSLGEPSGA---MKIPNRDSGIESPSSSVASENFP--------------- 87

  Fly   450 DVGFIEQCTRRFESASPSPMPPAYSSGQHSPILLPTTIADAVGHQ-QPESGSD----------LI 503
                   |....| .||||.    ..|.|     |....|:...| .|:.|.|          :.
  Rat    88 -------CEEGSE-GSPSPA----ILGLH-----PEVAVDSRAPQDNPQEGEDSGVGEDPDPKIT 135

  Fly   504 TIRLQADEQGRYGFNVKGGVDLSLP---VQVSKVVPHTPADRCTPRVCEGDEVLMINGRDVHGLR 565
            ..|.:.|         .|....|.|   :.:::.:.|| .:....|:...|:|......:. |:.
  Rat   136 PCRPEED---------VGSTQCSDPQKLLHIAQELLHT-EEAYVKRLHLLDQVFCAKLTEA-GIP 189

  Fly   566 HEQVVAMIRDCR--HQASGELLL-----------TVRP------QRSAPLLLEEEPLY-QYVPES 610
            .|....:..:..  ::..|:.||           ..:|      |:.||.|    .:| :||...
  Rat   190 PEVTTGIFSNISSIYRFHGQFLLPGLKKRITEEWDTKPRLGDILQKLAPFL----KMYGEYVKNF 250

  Fly   611 DE-IGSHSNLLDGDALFTQSLLLLSDGLASGALLAQYELM--YRKNP--DLAITE--ARKPANAP 668
            |. :|..|........|...:..:......|.|..|:.::  .::.|  :|.:.:  .|.|.:||
  Rat   251 DRAMGLVSTWTQRSPQFKDVIHTIQKQEVCGNLTLQHHMLEPVQRVPRYELLLKDYLKRLPRDAP 315

  Fly   669 KNRYRDISPYDCTRVSLVNSLTGDYINA-------------------------NYVNMEIPGGAV 708
            ..:       |..|...:.|:..|:.||                         |..|..|..|.:
  Rat   316 DRK-------DAERSLELISIAADHSNAAIRKMEKMHKLLEVYEQLGGEEDIVNPANELIKEGNI 373

  Fly   709 NRYIATQGPLASTTTDFWRMVQQESSHLL----VMLTTVMESGRQKCHQYWPVTGEELQL-AEGF 768
            .:..|..|    ||.|         .||.    |||..|                .:|:| .:.|
  Rat   374 QKLSAKNG----TTQD---------RHLFLFNNVMLYCV----------------PKLRLMGQKF 409

  Fly   769 SVRCLSEKPDETGSFVFREFVLKDKHEQRHIHHMQYLAWPDHCVPSDPNLFLEFTERVRAARNRT 833
            |||   ||.|           :.|...|            |...|:....|: .|.|.|:...:|
  Rat   410 SVR---EKMD-----------ISDLQVQ------------DVVKPNAARTFI-ITGRKRSLELQT 447

  Fly   834 LLQEIEESLKQVRLMDADADADENGGLMRERKCAASNGATPEDETPVSTSVHQCISAANP--PVI 896
            ..:  ||..:.::::.|..:..:    .:.....|.:||..::|.| |.|..|.:.:|.|  |..
  Rat   448 RTE--EEKKEWIQVIQATVEKHK----QKSETFRAFSGACTQEEEP-SLSPDQPVLSAGPVEPAG 505

  Fly   897 VHCSAGIGRTGVLILMDTALALMEAREPVYPLDIVRTMRDQ-----RAC--MVQNVSQYRFVC-- 952
            |..|:| |..|:           |:|:.     ..:|.||:     ::|  ...::::.|:.|
  Rat   506 VADSSG-GTPGI-----------ESRKL-----SSKTRRDKEKPGCKSCGETFNSITKRRYRCKL 553

  Fly   953 --ECIC 956
              |.||
  Rat   554 CGEVIC 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptpmeg	NP_001163309.2	B41	35..232	CDD:214604
		FERM_N	38..102	CDD:286467
		FERM_M	125..232	CDD:278785
		FERM_C_PTPN4_PTPN3_like	226..320	CDD:270010
		FA	333..369	CDD:285894
		PDZ_signaling	502..589	CDD:238492	15/102 (15%)
		Y_phosphatase	666..955	CDD:278528	69/331 (21%)
		PTPc	668..955	CDD:238006	68/329 (21%)
Fgd3	XP_008769765.1	RhoGEF	157..336	CDD:279015	35/191 (18%)
		PH-like	367..474	CDD:302622	34/168 (20%)
		PH	367..465	CDD:278594	34/155 (22%)
		FYVE_FGD3	527..580	CDD:277279	8/33 (24%)
		PH2_FGD1-4	606..710	CDD:270056
		PH	622..711	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910